2021 ICD-10-CM Diagnosis Code B45.1

Cerebral cryptococcosis

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • B45.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM B45.1 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of B45.1 - other international versions of ICD-10 B45.1 may differ.
Applicable To
  • Cryptococcal meningitis
  • Cryptococcosis meningocerebralis
The following code(s) above B45.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to B45.1:
  • A00-B99
    2021 ICD-10-CM Range A00-B99

    Certain infectious and parasitic diseases

    Includes
    • diseases generally recognized as communicable or transmissible
    Type 1 Excludes
    • certain localized infections - see body system-related chapters
    Type 2 Excludes
    • carrier or suspected carrier of infectious disease (Z22.-)
    • infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
    • infectious and parasitic diseases specific to the perinatal period (P35-P39)
    • influenza and other acute respiratory infections (J00-J22)
    Use Additional
    • code to identify resistance to antimicrobial drugs (Z16.-)
    Certain infectious and parasitic diseases
  • B35-B49
    2021 ICD-10-CM Range B35-B49

    Mycoses

    Type 2 Excludes
    • hypersensitivity pneumonitis due to organic dust (J67.-)
    • mycosis fungoides (C84.0-)
    Mycoses
Approximate Synonyms
  • Cryptococcal meningitis
Clinical Information
  • Meningeal inflammation produced by cryptococcus neoformans, an encapsulated yeast that tends to infect individuals with acquired immunodeficiency syndrome and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature headache; nausea; photophobia; focal neurologic deficits; seizures; cranial neuropathies; and hydrocephalus. (from Adams et al., Principles of Neurology, 6th ed, pp721-2)
ICD-10-CM B45.1 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 023 Craniotomy with major device implant or acute complex cns principal diagnosis with mcc or chemotherapy implant or epilepsy with neurostimulator
  • 024 Craniotomy with major device implant or acute complex cns principal diagnosis without mcc
  • 097 Non-bacterial infection of nervous system except viral meningitis with mcc
  • 098 Non-bacterial infection of nervous system except viral meningitis with cc
  • 099 Non-bacterial infection of nervous system except viral meningitis without cc/mcc
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems

Convert B45.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to B45.1:
  • Type 1 Excludes: G02
    ICD-10-CM Diagnosis Code G02

    Meningitis in other infectious and parasitic diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • African trypanosomiasis (B56.-)
    • poliovirus infection (A80.-)
    Type 1 Excludes
    • candidal meningitis (B37.5)
    • coccidioidomycosis meningitis (B38.4)
    • cryptococcal meningitis (B45.1)
    • herpesviral [herpes simplex] meningitis (B00.3)
    • infectious mononucleosis complicated by meningitis (B27.- with fourth character 2)
    • measles complicated by meningitis (B05.1)
    • meningoencephalitis and meningomyelitis in other infectious and parasitic diseases classified elsewhere (G05)
    • mumps meningitis (B26.1)
    • rubella meningitis (B06.02)
    • varicella [chickenpox] meningitis (B01.0)
    • zoster meningitis (B02.1)

Diagnosis Index entries containing back-references to B45.1:
  • Cryptococcosis, cryptococcus (infection) (neoformans) B45.9
    ICD-10-CM Diagnosis Code B45.9

    Cryptococcosis, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    • cerebral B45.1
    • meningitis B45.1
    • meningocerebralis B45.1
  • Encephalitis (chronic) (hemorrhagic) (idiopathic) (nonepidemic) (spurious) (subacute) G04.90
    ICD-10-CM Diagnosis Code G04.90

    Encephalitis and encephalomyelitis, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Ventriculitis (cerebral) NOS
    • Torula, torular B45.1 (cryptococcal)
  • Meningitis (basal) (basic) (brain) (cerebral) (cervical) (congestive) (diffuse) (hemorrhagic) (infantile) (membranous) (metastatic) (nonspecific) (pontine) (progressive) (simple) (spinal) (subacute) (sympathetic) (toxic) G03.9
    ICD-10-CM Diagnosis Code G03.9

    Meningitis, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Arachnoiditis (spinal) NOS
    • cryptococcal B45.1
    • Torula histolytica B45.1 (cryptococcal)
  • Meningoencephalomyelitis - see also Meningoencephalitis
  • Meningomyelitis - see also Meningoencephalitis
    • cryptococcal B45.1

ICD-10-CM Codes Adjacent To B45.1
B44.0 Invasive pulmonary aspergillosis
B44.1 Other pulmonary aspergillosis
B44.2 Tonsillar aspergillosis
B44.7 Disseminated aspergillosis
B44.8 Other forms of aspergillosis
B44.81 Allergic bronchopulmonary aspergillosis
B44.89 Other forms of aspergillosis
B44.9 Aspergillosis, unspecified
B45 Cryptococcosis
B45.0 Pulmonary cryptococcosis
B45.1 Cerebral cryptococcosis
B45.2 Cutaneous cryptococcosis
B45.3 Osseous cryptococcosis
B45.7 Disseminated cryptococcosis
B45.8 Other forms of cryptococcosis
B45.9 Cryptococcosis, unspecified
B46 Zygomycosis
B46.0 Pulmonary mucormycosis
B46.1 Rhinocerebral mucormycosis
B46.2 Gastrointestinal mucormycosis
B46.3 Cutaneous mucormycosis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.