2021 ICD-10-CM Diagnosis Code C25.4

Malignant neoplasm of endocrine pancreas

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • C25.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM C25.4 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of C25.4 - other international versions of ICD-10 C25.4 may differ.
Applicable To
  • Malignant neoplasm of islets of Langerhans
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code to identify any functional activity.
The following code(s) above C25.4 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C25.4:
  • C00-D49
    2021 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • C15-C26
    2021 ICD-10-CM Range C15-C26

    Malignant neoplasms of digestive organs

    Type 1 Excludes
    • Kaposi's sarcoma of gastrointestinal sites (C46.4)
    Type 2 Excludes
    • gastrointestinal stromal tumors (C49.A-)
    Malignant neoplasms of digestive organs
  • C25
    ICD-10-CM Diagnosis Code C25

    Malignant neoplasm of pancreas

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Code Also
    • exocrine pancreatic insufficiency (K86.81)
    Use Additional
    • code to identify:
    • alcohol abuse and dependence (F10.-)
    Malignant neoplasm of pancreas
Approximate Synonyms
  • Cancer of the islets of langerhans
  • Malignant glucagonoma
  • Primary malignant neoplasm of islets of langerhans
Clinical Information
  • A malignant endocrine neoplasm arising from islets of langerhans of the pancreas.
  • A primary malignant neoplasm of the pancreatic islet cells. Usually it involves the non-insulin-producing cell types, the pancreatic alpha cells and the pancreatic delta cells (somatostatin-secreting cells) in glucagonoma and somatostatinoma, respectively.
  • An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 hpf. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.
  • Cancer arising from cells in the islets of langerhans, which are found in the pancreas.
ICD-10-CM C25.4 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 435 Malignancy of hepatobiliary system or pancreas with mcc
  • 436 Malignancy of hepatobiliary system or pancreas with cc
  • 437 Malignancy of hepatobiliary system or pancreas without cc/mcc

Convert C25.4 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to C25.4:
  • Type 1 Excludes: C75
    , C75
    ICD-10-CM Diagnosis Code C75

    Malignant neoplasm of other endocrine glands and related structures

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • malignant carcinoid tumors (C7A.0-)
    • malignant neoplasm of adrenal gland (C74.-)
    • malignant neoplasm of endocrine pancreas (C25.4)
    • malignant neoplasm of islets of Langerhans (C25.4)
    • malignant neoplasm of ovary (C56.-)
    • malignant neoplasm of testis (C62.-)
    • malignant neoplasm of thymus (C37)
    • malignant neoplasm of thyroid gland (C73)
    • malignant neuroendocrine tumors (C7A.-)
    ICD-10-CM Diagnosis Code C75

    Malignant neoplasm of other endocrine glands and related structures

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • malignant carcinoid tumors (C7A.0-)
    • malignant neoplasm of adrenal gland (C74.-)
    • malignant neoplasm of endocrine pancreas (C25.4)
    • malignant neoplasm of islets of Langerhans (C25.4)
    • malignant neoplasm of ovary (C56.-)
    • malignant neoplasm of testis (C62.-)
    • malignant neoplasm of thymus (C37)
    • malignant neoplasm of thyroid gland (C73)
    • malignant neuroendocrine tumors (C7A.-)
  • Type 2 Excludes: C7A
    ICD-10-CM Diagnosis Code C7A

    Malignant neuroendocrine tumors

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Code Also
    • any associated multiple endocrine neoplasia [MEN] syndromes (E31.2-)
    Type 2 Excludes
    • malignant pancreatic islet cell tumors (C25.4)
    • Merkel cell carcinoma (C4A.-)
    Use Additional
    • code to identify any associated endocrine syndrome, such as:
    • carcinoid syndrome (E34.0)

Diagnosis Index entries containing back-references to C25.4:

ICD-10-CM Codes Adjacent To C25.4
C24 Malignant neoplasm of other and unspecified parts of biliary tract
C24.0 Malignant neoplasm of extrahepatic bile duct
C24.1 Malignant neoplasm of ampulla of Vater
C24.8 Malignant neoplasm of overlapping sites of biliary tract
C24.9 Malignant neoplasm of biliary tract, unspecified
C25 Malignant neoplasm of pancreas
C25.0 Malignant neoplasm of head of pancreas
C25.1 Malignant neoplasm of body of pancreas
C25.2 Malignant neoplasm of tail of pancreas
C25.3 Malignant neoplasm of pancreatic duct
C25.4 Malignant neoplasm of endocrine pancreas
C25.7 Malignant neoplasm of other parts of pancreas
C25.8 Malignant neoplasm of overlapping sites of pancreas
C25.9 Malignant neoplasm of pancreas, unspecified
C26 Malignant neoplasm of other and ill-defined digestive organs
C26.0 Malignant neoplasm of intestinal tract, part unspecified
C26.1 Malignant neoplasm of spleen
C26.9 Malignant neoplasm of ill-defined sites within the digestive system
C30 Malignant neoplasm of nasal cavity and middle ear
C30.0 Malignant neoplasm of nasal cavity
C30.1 Malignant neoplasm of middle ear

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.