Non-specific code icon 2014 ICD-10-CM Diagnosis Code C83.3

Diffuse large B-cell lymphoma

  • C83.3 is not a billable ICD-10-CM diagnosis code and cannot be used to indicate a medical diagnosis as there are 10 codes below C83.3 that describe this diagnosis in greater detail.
  • ICD-10-CM codes become active beginning October 1, 2014, therefore, this and all ICD-10-CM diagnosis codes should only be used for training or planning purposes until then.
Clinical Information
  • A non-hodgkin lymphoma characterized by a diffuse proliferation of predominantly large neoplastic b lymphocytes. It is the most frequently seen type of non-hodgkin lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities include t-cell/histiocyte rich large b-cell lymphoma, primary diffuse large b-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary cutaneous diffuse large b-cell lymphoma, leg type, and alk-positive large b-cell lymphoma.
  • A non-hodgkin lymphoma characterized by a diffuse proliferation of predominantly large neoplastic b lymphocytes. It is the most frequently seen type of non-hodgkin lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, t-cell/histiocyte rich lymphoma, anaplastic lymphoma, plasmablastic lymphoma, and diffuse large b-cell lymphoma with expression of full-length alk. (who, 2001)
  • A type of b-cell non-hodgkin lymphoma (cancer of the immune system) that is usually aggressive (fast-growing). It is the most common type of non-hodgkin lymphoma, and is marked by rapidly growing tumors in the lymph nodes, spleen, liver, bone marrow, or other organs. Other symptoms include fever, night sweats, and weight loss. There are several subtypes of diffuse large b-cell lymphoma.
  • Malignant lymphoma composed of large b lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of b-lymphocytes at midstage in the process of differentiation.
Applicable To
  • Anaplastic diffuse large B-cell lymphoma
  • CD30-positive diffuse large B-cell lymphoma
  • Centroblastic diffuse large B-cell lymphoma
  • Diffuse large B-cell lymphoma, subtype not specified
  • Immunoblastic diffuse large B-cell lymphoma
  • Plasmablastic diffuse large B-cell lymphoma
  • Diffuse large B-cell lymphoma, subtype not specified
  • T-cell rich diffuse large B-cell lymphoma
Type 1 Excludes
  • mediastinal (thymic) large B-cell lymphoma (C85.2-)
  • mature T/NK-cell lymphomas (C84.-)
Mortality Data
  • Between 1999-2007 there were 10,750 deaths in the United States where ICD-10 C83.3 was indicated as the underlying cause of death [source: cdc.govlink to cdc.gov]
  • ICD-10 C83.3 as underlying cause of death data broken down by: gender, age, race, year