2021

  1. ICD-10-CM Codes
    2. ›
  2. C00-D49 Neoplasms
    3. ›
  3. D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
    4. ›
  4. D45- Polycythemia vera
    5. ›
  5. 2021 ICD-10-CM Diagnosis Code D45

2021 ICD-10-CM Diagnosis Code D45

Polycythemia vera

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • D45 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM D45 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D45 - other international versions of ICD-10 D45 may differ.
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D45. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • familial polycythemia (
    ICD-10-CM Diagnosis Code D75.0

    Familial erythrocytosis

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Benign polycythemia
    • Familial polycythemia
    Type 1 Excludes
    • hereditary ovalocytosis (D58.1)
    D75.0
    )
  • secondary polycythemia (
    ICD-10-CM Diagnosis Code D75.1

    Secondary polycythemia

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Acquired polycythemia
    • Emotional polycythemia
    • Erythrocytosis NOS
    • Hypoxemic polycythemia
    • Nephrogenous polycythemia
    • Polycythemia due to erythropoietin
    • Polycythemia due to fall in plasma volume
    • Polycythemia due to high altitude
    • Polycythemia due to stress
    • Polycythemia NOS
    • Relative polycythemia
    Type 1 Excludes
    • polycythemia neonatorum (P61.1)
    • polycythemia vera (D45)
    D75.1
    )
The following code(s) above D45 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D45:
  • C00-D49
    2021 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • D37-D48
    2021 ICD-10-CM Range D37-D48

    Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes

    Note
    • Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made.
    Type 1 Excludes
    • neoplasms of unspecified behavior (D49.-)
    Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
Approximate Synonyms
  • Chronic erythremia in relapse
  • Leukemia, erythremia, chronic, in remission
  • Polycythemia vera (clinical)
  • Polycythemia vera in relapse
  • Polycythemia vera in remission
Clinical Information
  • A chronic myeloproliferative neoplasm characterized by an increased red blood cell production. Excessive proliferation of the myeloid lineage is observed as well. The major symptoms are related to hypertension or to vascular abnormalities caused by the increased red cell mass. The cause is unknown. With currently available treatment, the median survival exceeds 10 years. (who, 2001)
  • A condition that produces excessive red blood cells
  • A disease in which there are too many red blood cells in the bone marrow and blood, causing the blood to thicken. The number of white blood cells and platelets may also increase. The extra blood cells may collect in the spleen and cause it to become enlarged. They may also cause bleeding problems and make clots form in blood vessels.
  • A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
  • Myeloproliferative disorder characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume; associated frequently with splenomegaly, leukocytosis, and thrombocythemia.
ICD-10-CM D45 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 820 Lymphoma and leukemia with major o.r. Procedures with mcc
  • 821 Lymphoma and leukemia with major o.r. Procedures with cc
  • 822 Lymphoma and leukemia with major o.r. Procedures without cc/mcc
  • 823 Lymphoma and non-acute leukemia with other procedures with mcc
  • 824 Lymphoma and non-acute leukemia with other procedures with cc
  • 825 Lymphoma and non-acute leukemia with other procedures without cc/mcc
  • 840 Lymphoma and non-acute leukemia with mcc
  • 841 Lymphoma and non-acute leukemia with cc
  • 842 Lymphoma and non-acute leukemia without cc/mcc

Convert D45 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to D45:
  • Code Also: D47.02
    , I27.29
    ICD-10-CM Diagnosis Code D47.02

    Systemic mastocytosis

      2018 - New Code 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Indolent systemic mastocytosis
    • Isolated bone marrow mastocytosis
    • Smoldering systemic mastocytosis
    • Systemic mastocytosis, with an associated hematological non-mast cell lineage disease (SM-AHNMD)
    Code Also
    • , if applicable, any associated hematological non-mast cell lineage disease, such as:
    • acute myeloid leukemia (C92.6-, C92.A-)
    • chronic myelomonocytic leukemia (C93.1-)
    • essential thrombocytosis (D47.3)
    • hypereosinophilic syndrome (D72.1)
    • myelodysplastic syndrome (D46.9)
    • myeloproliferative syndrome (D47.1)
    • non-Hodgkin lymphoma (C82-C85)
    • plasma cell myeloma (C90.0-)
    • polycythemia vera (D45)
    Type 1 Excludes
    • aggressive systemic mastocytosis (C96.21)
    • mast cell leukemia (C94.3-)
    ICD-10-CM Diagnosis Code I27.29

    Other secondary pulmonary hypertension

      2018 - New Code 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Group 5 pulmonary hypertension
    • Pulmonary hypertension with unclear multifactorial mechanisms
    • Pulmonary hypertension due to hematologic disorders
    • Pulmonary hypertension due to metabolic disorders
    • Pulmonary hypertension due to other systemic disorders
    Code Also
    • other associated disorders, if known, such as:
    • chronic myeloid leukemia (C92.10-C92.22)
    • essential thrombocythemia (D47.3)
    • Gaucher disease (E75.22)
    • hypertensive chronic kidney disease with end stage renal disease (I12.0, I13.11, I13.2)
    • hyperthyroidism (E05.-)
    • hypothyroidism (E00-E03)
    • polycythemia vera (D45)
    • sarcoidosis (D86.-)
  • Type 1 Excludes: D75.1
    , R71
    ICD-10-CM Diagnosis Code D75.1

    Secondary polycythemia

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Acquired polycythemia
    • Emotional polycythemia
    • Erythrocytosis NOS
    • Hypoxemic polycythemia
    • Nephrogenous polycythemia
    • Polycythemia due to erythropoietin
    • Polycythemia due to fall in plasma volume
    • Polycythemia due to high altitude
    • Polycythemia due to stress
    • Polycythemia NOS
    • Relative polycythemia
    Type 1 Excludes
    • polycythemia neonatorum (P61.1)
    • polycythemia vera (D45)
    ICD-10-CM Diagnosis Code R71

    Abnormality of red blood cells

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • anemias (D50-D64)
    • anemia of premature infant (P61.2)
    • benign (familial) polycythemia (D75.0)
    • congenital anemias (P61.2-P61.4)
    • newborn anemia due to isoimmunization (P55.-)
    • polycythemia neonatorum (P61.1)
    • polycythemia NOS (D75.1)
    • polycythemia vera (D45)
    • secondary polycythemia (D75.1)

Diagnosis Index entries containing back-references to D45:
  • Erythremia (acute) C94.0-
    ICD-10-CM Diagnosis Code C94.0-

    Acute erythroid leukemia

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Applicable To
    • Acute myeloid leukemia M6(a)(b)
    • Erythroleukemia
    • chronic D45
  • Heilmeyer-Schoner disease D45
  • Polycythemia (secondary) D75.1
    ICD-10-CM Diagnosis Code D75.1

    Secondary polycythemia

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Acquired polycythemia
    • Emotional polycythemia
    • Erythrocytosis NOS
    • Hypoxemic polycythemia
    • Nephrogenous polycythemia
    • Polycythemia due to erythropoietin
    • Polycythemia due to fall in plasma volume
    • Polycythemia due to high altitude
    • Polycythemia due to stress
    • Polycythemia NOS
    • Relative polycythemia
    Type 1 Excludes
    • polycythemia neonatorum (P61.1)
    • polycythemia vera (D45)
    • vera D45

ICD-10-CM Codes Adjacent To D45
D44.10 Neoplasm of uncertain behavior of unspecified adrenal gland
D44.11 Neoplasm of uncertain behavior of right adrenal gland
D44.12 Neoplasm of uncertain behavior of left adrenal gland
D44.2 Neoplasm of uncertain behavior of parathyroid gland
D44.3 Neoplasm of uncertain behavior of pituitary gland
D44.4 Neoplasm of uncertain behavior of craniopharyngeal duct
D44.5 Neoplasm of uncertain behavior of pineal gland
D44.6 Neoplasm of uncertain behavior of carotid body
D44.7 Neoplasm of uncertain behavior of aortic body and other paraganglia
D44.9 Neoplasm of uncertain behavior of unspecified endocrine gland
D45 Polycythemia vera
D46 Myelodysplastic syndromes
D46.0 Refractory anemia without ring sideroblasts, so stated
D46.1 Refractory anemia with ring sideroblasts
D46.2 Refractory anemia with excess of blasts [RAEB]
D46.20 Refractory anemia with excess of blasts, unspecified
D46.21 Refractory anemia with excess of blasts 1
D46.22 Refractory anemia with excess of blasts 2
D46.A Refractory cytopenia with multilineage dysplasia
D46.B Refractory cytopenia with multilineage dysplasia and ring sideroblasts
D46.C Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality

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