Specific code icon 2014 ICD-10-CM Diagnosis Code D46.9

Myelodysplastic syndrome, unspecified

  • D46.9 is a billable ICD-10-CM code that can be used to specify a diagnosis.
  • On October 1, 2015 ICD-10-CM will replace ICD-9-CM in the United States, therefore, D46.9 and all other ICD-10-CM codes should only be used for training or planning purposes until then.
Clinical Information
  • (mye-eh-lo-dis-plas-tik sin-drome) disease in which the bone marrow does not function normally.
  • A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the who guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (who, 2001)
  • A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow.
  • A group of diseases in which the bone marrow does not make enough healthy blood cells.
  • Abnormal bone marrow cells that may lead to myelogenous leukemia.
  • Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into acute myeloid leukemia.
  • Your bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. If you have a myelodysplastic syndrome, the stem cells do not mature into healthy blood cells. This leaves less room for healthy cells, which can lead to infection, anemia, or easy bleeding.myelodysplastic syndromes often do not cause early symptoms and are sometimes found during a routine blood test. If you have symptoms, they may include
    • shortness of breath
    • weakness or feeling tired
    • skin that is paler than usual
    • easy bruising or bleeding
    • pinpoint spots under the skin caused by bleeding
    • fever or frequent infections
    myelodysplastic syndromes are rare. People at higher risk are over 60, have had chemotherapy or radiation therapy, or have been exposed to certain chemicals. Treatment options include transfusions, drug therapy, chemotherapy, and blood or bone marrow stem cell transplants. nih national cancer institute
Applicable To
  • Myelodysplasia NOS
Description Synonyms
  • High grade myelodysplastic syndrome lesions
  • Low grade myelodysplastic syndrome lesions
  • Myelodysplastic syndrome
  • Myelodysplastic syndrome (clinical)
  • Myelodysplastic syndrome lesions, high grade
  • Myelodysplastic syndrome lesions, low grade
Mortality Data
  • Between 1999-2007 there were 41,231 deaths in the United States where ICD-10 D46.9 was indicated as the underlying cause of death [source: cdc.govlink to cdc.gov]
  • ICD-10 D46.9 as underlying cause of death data broken down by: gender, age, race, year
ICD-10-CM D46.9 is grouped within Diagnostic Related Group(s) (MS-DRG v30.0):
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc
Convert ICD-10-CM D46.9 to ICD-9-CM
The following ICD-10-CM Index entries contain back-references to ICD-10-CM D46.9: