2017/18 ICD-10-CM Diagnosis Code D56.0

Alpha thalassemia

Applicable To
  • Alpha thalassemia major
  • Hemoglobin H Constant Spring
  • Hemoglobin H disease
  • Hydrops fetalis due to alpha thalassemia
  • Severe alpha thalassemia
  • Triple gene defect alpha thalassemia
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code, if applicable, for hydrops fetalis due to alpha thalassemia (
    ICD-10-CM Diagnosis Code P56.99

    Hydrops fetalis due to other hemolytic disease

      2016 2017 2018 Billable/Specific Code Code on Newborn Record
    P56.99
    )
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D56.0. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • alpha thalassemia trait or minor (
    ICD-10-CM Diagnosis Code D56.3

    Thalassemia minor

      2016 2017 2018 Billable/Specific Code
    Applicable To
    • Alpha thalassemia minor
    • Alpha thalassemia silent carrier
    • Alpha thalassemia trait
    • Beta thalassemia minor
    • Beta thalassemia trait
    • Delta-beta thalassemia minor
    • Delta-beta thalassemia trait
    • Thalassemia trait NOS
    Type 1 Excludes
    • alpha thalassemia (D56.0)
    • beta thalassemia (D56.1)
    • delta-beta thalassemia (D56.2)
    • hemoglobin E-beta thalassemia (D56.5)
    • sickle-cell trait (D57.3)
    D56.3
    )
  • asymptomatic alpha thalassemia (
    ICD-10-CM Diagnosis Code D56.3

    Thalassemia minor

      2016 2017 2018 Billable/Specific Code
    Applicable To
    • Alpha thalassemia minor
    • Alpha thalassemia silent carrier
    • Alpha thalassemia trait
    • Beta thalassemia minor
    • Beta thalassemia trait
    • Delta-beta thalassemia minor
    • Delta-beta thalassemia trait
    • Thalassemia trait NOS
    Type 1 Excludes
    • alpha thalassemia (D56.0)
    • beta thalassemia (D56.1)
    • delta-beta thalassemia (D56.2)
    • hemoglobin E-beta thalassemia (D56.5)
    • sickle-cell trait (D57.3)
    D56.3
    )
  • hydrops fetalis due to isoimmunization (
    ICD-10-CM Diagnosis Code P56.0

    Hydrops fetalis due to isoimmunization

      2016 2017 2018 Billable/Specific Code Code on Newborn Record
    P56.0
    )
  • hydrops fetalis not due to immune hemolysis (
    ICD-10-CM Diagnosis Code P83.2

    Hydrops fetalis not due to hemolytic disease

      2016 2017 2018 Billable/Specific Code Code on Newborn Record
    Applicable To
    • Hydrops fetalis NOS
    P83.2
    )
The following code(s) above D56.0 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D56.0:
  • D50-D89
    2018 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D56
    ICD-10-CM Diagnosis Code D56

    Thalassemia

      2016 2017 2018 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • sickle-cell thalassemia (D57.4-)
    Thalassemia
Approximate Synonyms Clinical Information ICD-10-CM D56.0 is grouped within Diagnostic Related Group(s) (MS-DRG v35.0):

Convert D56.0 to ICD-9-CM

Code History
Code annotations containing back-references to D56.0:

Diagnosis Index entries containing back-references to D56.0:

ICD-10-CM Codes Adjacent To D56.0
D53.8 Other specified nutritional anemias
D53.9 Nutritional anemia, unspecified
D55 Anemia due to enzyme disorders
D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
D55.1 Anemia due to other disorders of glutathione metabolism
D55.2 Anemia due to disorders of glycolytic enzymes
D55.3 Anemia due to disorders of nucleotide metabolism
D55.8 Other anemias due to enzyme disorders
D55.9 Anemia due to enzyme disorder, unspecified
D56 Thalassemia
D56.0 Alpha thalassemia
D56.1 Beta thalassemia
D56.2 Delta-beta thalassemia
D56.3 Thalassemia minor
D56.4 Hereditary persistence of fetal hemoglobin [HPFH]
D56.5 Hemoglobin E-beta thalassemia
D56.8 Other thalassemias
D56.9 Thalassemia, unspecified
D57 Sickle-cell disorders
D57.0 Hb-SS disease with crisis
D57.00 …… unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.