2017/18 ICD-10-CM Diagnosis Code D57

Sickle-cell disorders

Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code for any associated fever (
    ICD-10-CM Diagnosis Code R50.81

    Fever presenting with conditions classified elsewhere

      2016 2017 2018 Billable/Specific Code Manifestation Code
    Code First
    • underlying condition when associated fever is present, such as with:
    • leukemia (C91-C95)
    • neutropenia (D70.-)
    • sickle-cell disease (D57.-)
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D57. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • other hemoglobinopathies (
    ICD-10-CM Diagnosis Code D58
    • D58 Other hereditary hemolytic anemias
      • D58.0 Hereditary spherocytosis
      • D58.1 Hereditary elliptocytosis
      • D58.2 Other hemoglobinopathies
      • D58.8 Other specified hereditary hemolytic anemias
      • D58.9 Hereditary hemolytic anemia, unspecified
The following code(s) above D57 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D57:
  • D50-D89
    2018 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Approximate Synonyms Clinical Information Code History
Code annotations containing back-references to D57:

Diagnosis Index entries containing back-references to D57:

ICD-10-CM Codes Adjacent To D57
D55.9 Anemia due to enzyme disorder, unspecified
D56 Thalassemia
D56.0 Alpha thalassemia
D56.1 Beta thalassemia
D56.2 Delta-beta thalassemia
D56.3 Thalassemia minor
D56.4 Hereditary persistence of fetal hemoglobin [HPFH]
D56.5 Hemoglobin E-beta thalassemia
D56.8 Other thalassemias
D56.9 Thalassemia, unspecified
D57 Sickle-cell disorders
D57.0 Hb-SS disease with crisis
D57.00 …… unspecified
D57.01 Hb-SS disease with acute chest syndrome
D57.02 Hb-SS disease with splenic sequestration
D57.1 Sickle-cell disease without crisis
D57.2 Sickle-cell/Hb-C disease
D57.20 …… without crisis
D57.21 Sickle-cell/Hb-C disease with crisis
D57.211 Sickle-cell/Hb-C disease with acute chest syndrome
D57.212 Sickle-cell/Hb-C disease with splenic sequestration

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.