1. ICD-10-CM Codes
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2. D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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3. D65-D69 Coagulation defects, purpura and other hemorrhagic conditions
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4. D68- Other coagulation defects
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5. 2021 ICD-10-CM Diagnosis Code D68.59

2021 ICD-10-CM Diagnosis Code D68.59

Other primary thrombophilia

2016 2017 2018 2019 2020 2021 Billable/Specific Code

• D68.59 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2021 edition of ICD-10-CM D68.59 became effective on October 1, 2020.
• This is the American ICD-10-CM version of D68.59 - other international versions of ICD-10 D68.59 may differ.

• Antithrombin 3 deficiency
• Antithrombin iii deficiency
• Hereditary thrombophilia
• Hypercoagulability state
• Hypercoagulable state (tendency to form clots)
• Protein c deficiency disease
• Protein s deficiency disease

• A disorder of hemostasis in which there is a tendency for the occurrence of thrombosis.
• A rare disorder characterized by the presence of low levels of antithrombin iii which prohibits the formation of blood clots. It may be inherited, usually in an autosomal dominant pattern, or acquired. It may lead to venous thrombosis and pulmonary embolism.
• A rare thrombophilia disorder characterized by deficiency of protein c. It results in venous thromboembolism.
• A rare thrombophilia disorder characterized by deficiency of protein s. It results in venous thromboembolism.
• An absence or deficiency in protein c which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (stedman's med. Dict., 26th ed.)
• An absence or reduced level of antithrombin iii leading to an increased risk for thrombosis.
• An autosomal dominant disorder showing decreased levels of plasma protein s antigen or activity, associated with venous thrombosis and pulmonary embolism. Protein s is a vitamin k-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein c (also a vitamin k-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein c deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (from harrison's principles of internal medicine, 12th ed, p1511; wintrobe's clinical hematology, 9th ed, p1523)

• 814 Reticuloendothelial and immunity disorders with mcc
• 815 Reticuloendothelial and immunity disorders with cc
• 816 Reticuloendothelial and immunity disorders without cc/mcc

Convert D68.59 to ICD-9-CM

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change

• Deficiency, deficient
  • protein E46
    - see also Malnutrition
    ICD-10-CM Diagnosis Code E46

    Unspecified protein-calorie malnutrition

    2016 2017 2018 2019 2020 2021 Billable/Specific Code

    Applicable To

    • Malnutrition NOS
    • Protein-calorie imbalance NOS

    Type 1 Excludes

    • nutritional deficiency NOS (E63.9)
    • C D68.59
    • S D68.59
  • antithrombin D68.59 (antithrombin III)
• Hypercoagulable (state) D68.59
  • antithrombin D68.59 (III)
  • primary NEC D68.59
  • protein C deficiency D68.59
  • protein S deficiency D68.59
• Hypercoagulation D68.59 (state)
• Thrombophilia D68.59
  • primary NEC D68.59

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.