ICD-10-CM Codes
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D65-D69 Coagulation defects, purpura and other hemorrhagic conditions
D68- Other coagulation defects
2021 ICD-10-CM Diagnosis Code D68.61

2021 ICD-10-CM Diagnosis Code D68.61

Antiphospholipid syndrome

2016

2017

2018

2019

2020

2021

Billable/Specific Code

D68.61 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2021 edition of ICD-10-CM D68.61 became effective on October 1, 2020.
This is the American ICD-10-CM version of D68.61 - other international versions of ICD-10 D68.61 may differ.

Applicable To

Anticardiolipin syndrome
Antiphospholipid antibody syndrome

Type 1 Excludes

Type 1 Excludes Help

A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D68.61. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

anti-phospholipid antibody, finding without diagnosis (
ICD-10-CM Diagnosis Code R76.0
Raised antibody titer
Type 1 Excludes
- isoimmunization in pregnancy (O36.0-O36.1)
- isoimmunization affecting newborn (P55.-)
R76.0
)
anti-phospholipid antibody with hemorrhagic disorder (
ICD-10-CM Diagnosis Code D68.312
Antiphospholipid antibody with hemorrhagic disorder
Applicable To
- Lupus anticoagulant (LAC) with hemorrhagic disorder
- Systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder
Type 1 Excludes
- antiphospholipid antibody, finding without diagnosis (R76.0)
- antiphospholipid antibody syndrome (D68.61)
- antiphospholipid antibody with hypercoagulable state (D68.61)
- lupus anticoagulant (LAC) finding without diagnosis (R76.0)
- lupus anticoagulant (LAC) with hypercoagulable state (D68.62)
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
- systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.62)
D68.312
)
lupus anticoagulant syndrome (
ICD-10-CM Diagnosis Code D68.62
Lupus anticoagulant syndrome
Applicable To
- Lupus anticoagulant
- Presence of systemic lupus erythematosus [SLE] inhibitor
Type 1 Excludes
- anticardiolipin syndrome (D68.61)
- antiphospholipid syndrome (D68.61)
- lupus anticoagulant (LAC) finding without diagnosis (R76.0)
- lupus anticoagulant (LAC) with hemorrhagic disorder (D68.312)
D68.62
)

The following code(s) above D68.61 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D68.61:

D50-D89
2021 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D68
ICD-10-CM Diagnosis Code D68
Other coagulation defects
Type 1 Excludes
- abnormal coagulation profile (R79.1)
- coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
- coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
Other coagulation defects
D68.6
ICD-10-CM Diagnosis Code D68.6
Other thrombophilia
Applicable To
- Other hypercoagulable states
Type 1 Excludes
- diffuse or disseminated intravascular coagulation [DIC] (D65)
- heparin induced thrombocytopenia (HIT) (D75.82)
- hyperhomocysteinemia (E72.11)
Other thrombophilia

Approximate Synonyms

Anticardiolipin syndrome
Antiphospholipid syndrome complication in pregnancy
Antiphospholipid syndrome in childbirth
Antiphospholipid syndrome in pregnancy
Antiphospholipid syndrome postpartum
Postpartum (after childbirth) antiphospholipid syndrome
Primary antiphospholipid syndrome
Secondary antiphospholipid syndrome

Clinical Information

A syndrome associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses, marked by the presence of antibodies directed against phospholipids.
Associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses; involves the presence of antibodies directed against phospholipids; cardiolipins show markedly elevated levels of anticardiolipin antibodies; present also are high levels of lupus anticoagulant; in pregnancy it can cause abortion.
The presence of antibodies directed against phospholipids (antibodies, antiphospholipid). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (antibodies, anticardiolipin). Present also are high levels of lupus anticoagulant (lupus coagulation inhibitor).

ICD-10-CM D68.61 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):

814 Reticuloendothelial and immunity disorders with mcc
815 Reticuloendothelial and immunity disorders with cc
816 Reticuloendothelial and immunity disorders without cc/mcc

Convert D68.61 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change

Code annotations containing back-references to D68.61:

Type 1 Excludes: D68.312
, D68.312
, D68.5
, D68.62
, D68.62

ICD-10-CM Diagnosis Code D68.312
Antiphospholipid antibody with hemorrhagic disorder
Applicable To
- Lupus anticoagulant (LAC) with hemorrhagic disorder
- Systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder
Type 1 Excludes
- antiphospholipid antibody, finding without diagnosis (R76.0)
- antiphospholipid antibody syndrome (D68.61)
- antiphospholipid antibody with hypercoagulable state (D68.61)
- lupus anticoagulant (LAC) finding without diagnosis (R76.0)
- lupus anticoagulant (LAC) with hypercoagulable state (D68.62)
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
- systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.62)
ICD-10-CM Diagnosis Code D68.312
Antiphospholipid antibody with hemorrhagic disorder
Applicable To
- Lupus anticoagulant (LAC) with hemorrhagic disorder
- Systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder
Type 1 Excludes
- antiphospholipid antibody, finding without diagnosis (R76.0)
- antiphospholipid antibody syndrome (D68.61)
- antiphospholipid antibody with hypercoagulable state (D68.61)
- lupus anticoagulant (LAC) finding without diagnosis (R76.0)
- lupus anticoagulant (LAC) with hypercoagulable state (D68.62)
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
- systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.62)
ICD-10-CM Diagnosis Code D68.5
Primary thrombophilia
Applicable To
- Primary hypercoagulable states
Type 1 Excludes
- antiphospholipid syndrome (D68.61)
- lupus anticoagulant (D68.62)
- secondary activated protein C resistance (D68.69)
- secondary antiphospholipid antibody syndrome (D68.69)
- secondary lupus anticoagulant with hypercoagulable state (D68.69)
- secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
- systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)
- thrombotic thrombocytopenic purpura (M31.1)
ICD-10-CM Diagnosis Code D68.62
Lupus anticoagulant syndrome
Applicable To
- Lupus anticoagulant
- Presence of systemic lupus erythematosus [SLE] inhibitor
Type 1 Excludes
- anticardiolipin syndrome (D68.61)
- antiphospholipid syndrome (D68.61)
- lupus anticoagulant (LAC) finding without diagnosis (R76.0)
- lupus anticoagulant (LAC) with hemorrhagic disorder (D68.312)
ICD-10-CM Diagnosis Code D68.62
Lupus anticoagulant syndrome
Applicable To
- Lupus anticoagulant
- Presence of systemic lupus erythematosus [SLE] inhibitor
Type 1 Excludes
- anticardiolipin syndrome (D68.61)
- antiphospholipid syndrome (D68.61)
- lupus anticoagulant (LAC) finding without diagnosis (R76.0)
- lupus anticoagulant (LAC) with hemorrhagic disorder (D68.312)

Diagnosis Index entries containing back-references to D68.61:

Antibody
- anticardiolipin R76.0
  ICD-10-CM Diagnosis Code R76.0
  Raised antibody titer
  2016 2017 2018 2019 2020 2021 Billable/Specific Code
  Type 1 Excludes
  isoimmunization in pregnancy (O36.0-O36.1)
  isoimmunization affecting newborn (P55.-)
  - with
    - hypercoagulable state D68.61
- antiphosphatidylglycerol R76.0
  ICD-10-CM Diagnosis Code R76.0
  Raised antibody titer
  2016 2017 2018 2019 2020 2021 Billable/Specific Code
  Type 1 Excludes
  isoimmunization in pregnancy (O36.0-O36.1)
  isoimmunization affecting newborn (P55.-)
  - with
    - hypercoagulable state D68.61
- antiphosphatidylinositol R76.0
  ICD-10-CM Diagnosis Code R76.0
  Raised antibody titer
  2016 2017 2018 2019 2020 2021 Billable/Specific Code
  Type 1 Excludes
  isoimmunization in pregnancy (O36.0-O36.1)
  isoimmunization affecting newborn (P55.-)
  - with
    - hypercoagulable state D68.61
- antiphosphatidylserine R76.0
  ICD-10-CM Diagnosis Code R76.0
  Raised antibody titer
  2016 2017 2018 2019 2020 2021 Billable/Specific Code
  Type 1 Excludes
  isoimmunization in pregnancy (O36.0-O36.1)
  isoimmunization affecting newborn (P55.-)
  - with
    - hypercoagulable state D68.61
- antiphospholipid R76.0
  ICD-10-CM Diagnosis Code R76.0
  Raised antibody titer
  2016 2017 2018 2019 2020 2021 Billable/Specific Code
  Type 1 Excludes
  isoimmunization in pregnancy (O36.0-O36.1)
  isoimmunization affecting newborn (P55.-)
  - with
    - hypercoagulable state D68.61
Anticardiolipin syndrome D68.61
Antiphospholipid
- antibody
  - syndrome D68.61
Syndrome - see also Disease
- anticardiolipin D68.61 (-antibody)
- antiphospholipid D68.61 (-antibody)

ICD-10-CM Codes Adjacent To D68.61

D68.311 Acquired hemophilia

D68.312 Antiphospholipid antibody with hemorrhagic disorder

D68.318 Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors

D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants

D68.4 Acquired coagulation factor deficiency

D68.5 Primary thrombophilia

D68.51 Activated protein C resistance

D68.52 Prothrombin gene mutation

D68.59 Other primary thrombophilia

D68.6 Other thrombophilia

D68.61 Antiphospholipid syndrome

D68.62 Lupus anticoagulant syndrome

D68.69 Other thrombophilia

D68.8 Other specified coagulation defects

D68.9 Coagulation defect, unspecified

D69 Purpura and other hemorrhagic conditions

D69.0 Allergic purpura

D69.1 Qualitative platelet defects

D69.2 Other nonthrombocytopenic purpura

D69.3 Immune thrombocytopenic purpura

D69.4 Other primary thrombocytopenia

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2021 ICD-10-CM Diagnosis Code D68.61

Antiphospholipid syndrome

Raised antibody titer

Antiphospholipid antibody with hemorrhagic disorder

Lupus anticoagulant syndrome

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other coagulation defects

Other thrombophilia

Antiphospholipid antibody with hemorrhagic disorder

Antiphospholipid antibody with hemorrhagic disorder

Primary thrombophilia

Lupus anticoagulant syndrome

Lupus anticoagulant syndrome

Raised antibody titer

Raised antibody titer

Raised antibody titer

Raised antibody titer

Raised antibody titer