2017/18 ICD-10-CM Diagnosis Code D89.81

Graft-versus-host disease

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Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code to identify associated manifestations, such as:
  • desquamative dermatitis (
    ICD-10-CM Diagnosis Code L30.8

    Other specified dermatitis

      2016 2017 2018 Billable/Specific Code
    L30.8
    )
  • diarrhea (
    ICD-10-CM Diagnosis Code R19.7

    Diarrhea, unspecified

      2016 2017 2018 Billable/Specific Code
    Applicable To
    • Diarrhea NOS
    Type 1 Excludes
    • functional diarrhea (K59.1)
    • neonatal diarrhea (P78.3)
    • psychogenic diarrhea (F45.8)
    R19.7
    )
  • elevated bilirubin (
    ICD-10-CM Diagnosis Code R17

    Unspecified jaundice

      2016 2017 2018 Billable/Specific Code
    Type 1 Excludes
    R17
    )
  • hair loss (
    ICD-10-CM Diagnosis Code L65.9

    Nonscarring hair loss, unspecified

      2016 2017 2018 Billable/Specific Code
    Applicable To
    • Alopecia NOS
    L65.9
    )
Code First
Code First Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • underlying cause, such as:
  • complications of transplanted organs and tissue (
    ICD-10-CM Diagnosis Code T86
    • T86 Complications of transplanted organs and tiss...
      • T86.0 Complications of bone marrow transplant
        • T86.00 Unspecified complication of bone marrow trans...
        • T86.01 Bone marrow transplant rejection
        • T86.02 Bone marrow transplant failure
        • T86.03 Bone marrow transplant infection
        • T86.09 Other complications of bone marrow transplant...
      • T86.1 Complications of kidney transplant
        • T86.10 Unspecified complication of kidney transplant...
        • T86.11 Kidney transplant rejection
        • T86.12 Kidney transplant failure
        • T86.13 Kidney transplant infection
        • T86.19 Other complication of kidney transplant
      • T86.2 Complications of heart transplant
        • T86.20 Unspecified complication of heart transplant
        • T86.21 Heart transplant rejection
        • T86.22 Heart transplant failure
        • T86.23 Heart transplant infection
        • T86.29 Other complications of heart transplant
          • T86.290 Cardiac allograft vasculopathy
          • T86.298 Other complications of heart transplant
      • T86.3 Complications of heart-lung transplant
        • T86.30 Unspecified complication of heart-lung transp...
        • T86.31 Heart-lung transplant rejection
        • T86.32 Heart-lung transplant failure
        • T86.33 Heart-lung transplant infection
        • T86.39 Other complications of heart-lung transplant
      • T86.4 Complications of liver transplant
        • T86.40 Unspecified complication of liver transplant
        • T86.41 Liver transplant rejection
        • T86.42 Liver transplant failure
        • T86.43 Liver transplant infection
        • T86.49 Other complications of liver transplant
      • T86.5 Complications of stem cell transplant
      • T86.8 Complications of other transplanted organs an...
        • T86.81 Complications of lung transplant
          • T86.810 Lung transplant rejection
          • T86.811 Lung transplant failure
          • T86.812 Lung transplant infection
          • T86.818 Other complications of lung transplant
          • T86.819 Unspecified complication of lung transplant
        • T86.82 Complications of skin graft (allograft) (auto...
          • T86.820 Skin graft (allograft) rejection
          • T86.821 Skin graft (allograft) (autograft) failure
          • T86.822 Skin graft (allograft) (autograft) infection
          • T86.828 Other complications of skin graft (allograft)...
          • T86.829 Unspecified complication of skin graft (allog...
        • T86.83 Complications of bone graft
        • T86.84 Complications of corneal transplant
          • T86.840 Corneal transplant rejection
          • T86.841 Corneal transplant failure
          • T86.842 Corneal transplant infection
          • T86.848 Other complications of corneal transplant
          • T86.849 Unspecified complication of corneal transplan...
        • T86.85 Complication of intestine transplant
          • T86.850 Intestine transplant rejection
          • T86.851 Intestine transplant failure
          • T86.852 Intestine transplant infection
          • T86.858 Other complications of intestine transplant
          • T86.859 Unspecified complication of intestine transpl...
        • T86.89 Complications of other transplanted tissue
          • T86.890 Other transplanted tissue rejection
          • T86.891 Other transplanted tissue failure
          • T86.892 Other transplanted tissue infection
          • T86.898 Other complications of other transplanted tis...
          • T86.899 Unspecified complication of other transplante...
      • T86.9 Complication of unspecified transplanted orga...
        • T86.90 Unspecified complication of unspecified trans...
        • T86.91 Unspecified transplanted organ and tissue rej...
        • T86.92 Unspecified transplanted organ and tissue fai...
        • T86.93 Unspecified transplanted organ and tissue inf...
        • T86.99 Other complications of unspecified transplant...
    T86.-
    )
  • complications of blood transfusion (
    ICD-10-CM Diagnosis Code T80.89

    Other complications following infusion, transfusion and therapeutic injection

      2016 2017 2018 Non-Billable/Non-Specific Code
    Applicable To
    • Delayed serologic transfusion reaction (DSTR), unspecified incompatibility
    Use Additional
    • code to identify graft-versus-host reaction, if applicable, (D89.81-)
    T80.89
    )
The following code(s) above D89.81 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D89.81:
  • D50-D89
    2018 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D80-D89
    2018 ICD-10-CM Range D80-D89

    Certain disorders involving the immune mechanism

    Includes
    • defects in the complement system
    • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
    • sarcoidosis
    Type 1 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • functional disorders of polymorphonuclear neutrophils (D71)
    • human immunodeficiency virus [HIV] disease (B20)
    Certain disorders involving the immune mechanism
  • D89
    ICD-10-CM Diagnosis Code D89

    Other disorders involving the immune mechanism, not elsewhere classified

      2016 2017 2018 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • hyperglobulinemia NOS (R77.1)
    • monoclonal gammopathy (of undetermined significance) (D47.2)
    Type 2 Excludes
    • transplant failure and rejection (T86.-)
    Other disorders involving the immune mechanism, not elsewhere classified
Clinical Information Code History
Code annotations containing back-references to D89.81:
ICD-10-CM Codes Adjacent To D89.81
D89.1 Cryoglobulinemia
D89.2 Hypergammaglobulinemia, unspecified
D89.3 Immune reconstitution syndrome
D89.4 Mast cell activation syndrome and related disorders
D89.40 Mast cell activation, unspecified
D89.41 Monoclonal mast cell activation syndrome
D89.42 Idiopathic mast cell activation syndrome
D89.43 Secondary mast cell activation
D89.49 Other mast cell activation disorder
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.81 Graft-versus-host disease
D89.810 Acute graft-versus-host disease
D89.811 Chronic graft-versus-host disease
D89.812 Acute on chronic graft-versus-host disease
D89.813 …… unspecified
D89.82 Autoimmune lymphoproliferative syndrome [ALPS]
D89.89 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.9 Disorder involving the immune mechanism, unspecified
E00 Congenital iodine-deficiency syndrome
E00.0 Congenital iodine-deficiency syndrome, neurological type
E00.1 Congenital iodine-deficiency syndrome, myxedematous type

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.