2021 ICD-10-CM Diagnosis Code E88.02

Plasminogen deficiency

    2019 - New Code 2020 2021 Billable/Specific Code
  • E88.02 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM E88.02 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of E88.02 - other international versions of ICD-10 E88.02 may differ.
Applicable To
  • Dysplasminogenemia
  • Hypoplasminogenemia
  • Type 1 plasminogen deficiency
  • Type 2 plasminogen deficiency
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code for associated findings, such as:
  • hydrocephalus (
    ICD-10-CM Diagnosis Code G91.4

    Hydrocephalus in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 Billable/Specific Code Manifestation Code
    Code First
    • underlying condition, such as:
    • congenital syphilis (A50.4-)
    • neoplasm (C00-D49)
    • plasminogen deficiency (E88.02)
    Type 1 Excludes
    • hydrocephalus due to congenital toxoplasmosis (P37.1)
    G91.4
    )
  • otitis media (
    ICD-10-CM Diagnosis Code H67
    • H67 Otitis media in diseases classified elsewhere...
      • H67.1 Otitis media in diseases classified elsewhere...
      • H67.2 Otitis media in diseases classified elsewhere...
      • H67.3 Otitis media in diseases classified elsewhere...
      • H67.9 Otitis media in diseases classified elsewhere...
    H67.-
    )
  • respiratory disorder related to plasminogen deficiency (
    ICD-10-CM Diagnosis Code J99

    Respiratory disorders in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • amyloidosis (E85.-)
    • ankylosing spondylitis (M45)
    • congenital syphilis (A50.5)
    • cryoglobulinemia (D89.1)
    • early congenital syphilis (A50.0)
    • plasminogen deficiency (E88.02)
    • schistosomiasis (B65.0-B65.9)
    Type 1 Excludes
    J99
    )
Code Also
Code Also Help
A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.
  • , if applicable, ligneous conjunctivitis (
    ICD-10-CM Diagnosis Code H10.51

    Ligneous conjunctivitis

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Code Also
    • underlying condition if known, such as:
    • plasminogen deficiency (E88.02)
    H10.51
    )
The following code(s) above E88.02 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E88.02:
  • E00-E89
    2021 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2021 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndromes (Q79.6-)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E88
    ICD-10-CM Diagnosis Code E88

    Other and unspecified metabolic disorders

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • histiocytosis X (chronic) (C96.6)
    Use Additional
    • codes for associated conditions
    Other and unspecified metabolic disorders
  • E88.0
    ICD-10-CM Diagnosis Code E88.0

    Disorders of plasma-protein metabolism, not elsewhere classified

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • monoclonal gammopathy (of undetermined significance) (D47.2)
    • polyclonal hypergammaglobulinemia (D89.0)
    • Waldenström macroglobulinemia (C88.0)
    Type 2 Excludes
    • disorder of lipoprotein metabolism (E78.-)
    Disorders of plasma-protein metabolism, not elsewhere classified
ICD-10-CM E88.02 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 826 Myeloproliferative disorders or poorly differentiated neoplasms with major o.r. Procedures with mcc
  • 827 Myeloproliferative disorders or poorly differentiated neoplasms with major o.r. Procedures with cc
  • 828 Myeloproliferative disorders or poorly differentiated neoplasms with major o.r. Procedures without cc/mcc
  • 829 Myeloproliferative disorders or poorly differentiated neoplasms with other procedures with cc/mcc
  • 830 Myeloproliferative disorders or poorly differentiated neoplasms with other procedures without cc/mcc
  • 843 Other myeloproliferative disorders or poorly differentiated neoplastic diagnoses with mcc
  • 844 Other myeloproliferative disorders or poorly differentiated neoplastic diagnoses with cc
  • 845 Other myeloproliferative disorders or poorly differentiated neoplastic diagnoses without cc/mcc
Code History
  • 2019 (effective 10/1/2018): New code
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to E88.02:
  • Code Also: H10.51
    ICD-10-CM Diagnosis Code H10.51

    Ligneous conjunctivitis

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Code Also
    • underlying condition if known, such as:
    • plasminogen deficiency (E88.02)
  • Code First: J99
    , G91.4
    , H67
    ICD-10-CM Diagnosis Code J99

    Respiratory disorders in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • amyloidosis (E85.-)
    • ankylosing spondylitis (M45)
    • congenital syphilis (A50.5)
    • cryoglobulinemia (D89.1)
    • early congenital syphilis (A50.0)
    • plasminogen deficiency (E88.02)
    • schistosomiasis (B65.0-B65.9)
    Type 1 Excludes
    ICD-10-CM Diagnosis Code G91.4

    Hydrocephalus in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 Billable/Specific Code Manifestation Code
    Code First
    • underlying condition, such as:
    • congenital syphilis (A50.4-)
    • neoplasm (C00-D49)
    • plasminogen deficiency (E88.02)
    Type 1 Excludes
    • hydrocephalus due to congenital toxoplasmosis (P37.1)
    ICD-10-CM Diagnosis Code H67

    Otitis media in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Code First
    • underlying disease, such as:
    • plasminogen deficiency (E88.02)
    • viral disease NEC (B00-B34)
    Type 1 Excludes
    Use Additional
    • code for any associated perforated tympanic membrane (H72.-)

Diagnosis Index entries containing back-references to E88.02:
  • Deficiency, deficient
    • plasminogen E88.02 (type 1) (type 2)
  • Dysplasminogenemia E88.02
  • Hypoplasminogenemia E88.02

ICD-10-CM Codes Adjacent To E88.02
E87.5 Hyperkalemia
E87.6 Hypokalemia
E87.7 Fluid overload
E87.70 …… unspecified
E87.71 Transfusion associated circulatory overload
E87.79 Other fluid overload
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
E88 Other and unspecified metabolic disorders
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
E88.01 Alpha-1-antitrypsin deficiency
E88.02 Plasminogen deficiency
E88.09 Other disorders of plasma-protein metabolism, not elsewhere classified
E88.1 Lipodystrophy, not elsewhere classified
E88.2 Lipomatosis, not elsewhere classified
E88.3 Tumor lysis syndrome
E88.4 Mitochondrial metabolism disorders
E88.40 Mitochondrial metabolism disorder, unspecified
E88.41 MELAS syndrome
E88.42 MERRF syndrome
E88.49 Other mitochondrial metabolism disorders
E88.8 Other specified metabolic disorders

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.