Specific code icon 2015 ICD-10-CM Diagnosis Code Q93.3

Deletion of short arm of chromosome 4

    2015 Billable Code POA Exempt

  • Q93.3 is a billable ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • On October 1, 2015 ICD-10-CM will replace ICD-9-CM in the United States, therefore, Q93.3 - and all other ICD-10-CM codes - should only be used for training or planning purposes until then.
  • This is the American ICD-10-CM version of Q93.3. Other international ICD-10 versions may differ.

Clinical Information
  • A genetic syndrome resulting from a partial deletion on the short arm of chromosome 4 (4p deletion syndrome). It is characterized by mental retardation, microcephaly, seizures, muscle hypotonia, a distinctive facial appearance with prominent forehead and wide set eyes, growth failure with malformations of the spine, hands, and feet, congenital heart defects, and genitourinary malformations.
  • A syndrome caused by large deletions of the telomereic end of the short arm of chromosome 4 (4p) in wolf-hirchhorn syndrome critial regions (whscrs). Several candidate genes have been identified including whsc1 and whsch2 which appear to be responsible for the core phenotype and in combination with other linked and unlinked genes determine the severity and inclusion of rarer phenotypes. Most cases have a characteristic cranio-facial defect often referred to as "greek helmet face" - a combined result of microcephaly, broad forehead, prominent glabella, hypertelorism, high arched eyebrows, short philtrum and micrognathia. In addition there is mental retardation, growth delays, epilepsy, and frequently a wide range of midline and skeletal defects, including hypospadias; congenital heart defects; cleft lip; cleft palate; colobomata; clubfoot; clinodactyly; scoliosis; and kyphosis.
  • Partial deletion of the short arm of chromosome 4 with severe psychomotor deficiency and abnormalities of the craniofacial structures, heart, kidneys, and other organs. The most common defects include asymmetric skull, microcephaly, high forehead, beaked nose, hypertelorism, epicanthal folds, and prominent glabella. The phenotype of proximal interstitial deletion (del4p15) differs from that in the wolf-hirschhorn syndrome and is characterized by distinct facies, multiple minor congenital anomalies, psychomotor retardation and normal growth. Deletion 4p15-16 is expressed in a different phenotype which includes long face, midface hypoplasia, upslanted palpebral fissures, epicanthal folds, large beaked nose, highly arched palate, thick lower lip, micrognathia, broad and short neck, broad hands and feet, tall and thin habitus, delayed growth and mental development, and hypotonia.
Applicable To
  • Wolff-Hirschorn syndrome
Present On Admission
  • Q93.3 is considered exempt from POA reporting.
ICD-10-CM Q93.3 is grouped within Diagnostic Related Group (MS-DRG v30.0):
  • 884 Organic disturbances & mental retardation

Convert ICD-10-CM Q93.3 to ICD-9-CM

The following ICD-10-CM Index entries contain back-references to ICD-10-CM Q93.3: