2020 ICD-10-CM Diagnosis Code A48.3

Toxic shock syndrome

    2016 2017 2018 2019 2020 Billable/Specific Code
  • A48.3 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM A48.3 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of A48.3 - other international versions of ICD-10 A48.3 may differ.
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code to identify the organism (
    ICD-10-CM Diagnosis Code B95

    Streptococcus, Staphylococcus, and Enterococcus as the cause of diseases classified elsewhere

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    B95
    ,
    ICD-10-CM Diagnosis Code B96

    Other bacterial agents as the cause of diseases classified elsewhere

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    B96
    )
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as A48.3. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • endotoxic shock NOS (
    ICD-10-CM Diagnosis Code R57.8

    Other shock

      2016 2017 2018 2019 2020 Billable/Specific Code
    R57.8
    )
  • sepsis NOS (
    ICD-10-CM Diagnosis Code A41.9

    Sepsis, unspecified organism

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Septicemia NOS
    A41.9
    )
The following code(s) above A48.3 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to A48.3:
  • A00-B99
    2020 ICD-10-CM Range A00-B99

    Certain infectious and parasitic diseases

    Includes
    • diseases generally recognized as communicable or transmissible
    Type 1 Excludes
    • certain localized infections - see body system-related chapters
    Type 2 Excludes
    • carrier or suspected carrier of infectious disease (Z22.-)
    • infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
    • infectious and parasitic diseases specific to the perinatal period (P35-P39)
    • influenza and other acute respiratory infections (J00-J22)
    Use Additional
    • code to identify resistance to antimicrobial drugs (Z16.-)
    Certain infectious and parasitic diseases
  • A48
    ICD-10-CM Diagnosis Code A48

    Other bacterial diseases, not elsewhere classified

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    Other bacterial diseases, not elsewhere classified
Approximate Synonyms
  • Staphylococcal toxic shock syndrome
  • Toxic shock syndrome due to methicillin resistant staphylococcus aureus infection
  • Toxic shock syndrome due to methicillin susceptible staphylococcus aureus
  • Toxic shock syndrome due to mrsa
  • Toxic shock syndrome due to staphylococcus
Clinical Information
  • A fatal disease caused by an infection
  • A rare acute life-threatening systemic bacterial noncontagious illness caused by any of several related staphylococcal exotoxins. Tss characterised by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings consistent with tss include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria.
  • A rare acute life-threatening systemic bacterial noncontagious illness caused by any of several related staphylococcal exotoxins. Tss characterized by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings consistent with tss include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria.
  • A severe illness caused by infection with staphylococcus aureus and characterized by high fever of sudden onset, vomiting, diarrhea, and myalgia, followed by hypotension and in severe cases, shock; a sunburn-like rash with peeling of the skin, especially of the palms and soles, occurs during the acute phase.
  • Syndrome characterized by high fever, vomiting, diarrhea, confusion, and skin rash; almost all cases have been related to an infection with toxin-producing staphylococcus aureus.
ICD-10-CM A48.3 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 867 Other infectious and parasitic diseases diagnoses with mcc
  • 868 Other infectious and parasitic diseases diagnoses with cc
  • 869 Other infectious and parasitic diseases diagnoses without cc/mcc

Convert A48.3 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to A48.3:
  • Type 1 Excludes: R57
    ICD-10-CM Diagnosis Code R57

    Shock, not elsewhere classified

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • anaphylactic shock NOS (T78.2)
    • anaphylactic reaction or shock due to adverse food reaction (T78.0-)
    • anaphylactic shock due to adverse effect of correct drug or medicament properly administered (T88.6)
    • anaphylactic shock due to serum (T80.5-)
    • anesthetic shock (T88.3)
    • electric shock (T75.4)
    • obstetric shock (O75.1)
    • postprocedural shock (T81.1-)
    • psychic shock (F43.0)
    • shock complicating or following ectopic or molar pregnancy (O00-O07, O08.3)
    • shock due to lightning (T75.01)
    • traumatic shock (T79.4)
    • toxic shock syndrome (A48.3)
  • Type 2 Excludes: A41
    ICD-10-CM Diagnosis Code A41

    Other sepsis

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Code First
    • postprocedural sepsis (T81.4-)
    • sepsis during labor (O75.3)
    • sepsis following abortion, ectopic or molar pregnancy (O03-O07, O08.0)
    • sepsis following immunization (T88.0)
    • sepsis following infusion, transfusion or therapeutic injection (T80.2-)
    Type 1 Excludes
    Type 2 Excludes
    • sepsis (due to) (in) actinomycotic (A42.7)
    • sepsis (due to) (in) anthrax (A22.7)
    • sepsis (due to) (in) candidal (B37.7)
    • sepsis (due to) (in) Erysipelothrix (A26.7)
    • sepsis (due to) (in) extraintestinal yersiniosis (A28.2)
    • sepsis (due to) (in) gonococcal (A54.86)
    • sepsis (due to) (in) herpesviral (B00.7)
    • sepsis (due to) (in) listerial (A32.7)
    • sepsis (due to) (in) melioidosis (A24.1)
    • sepsis (due to) (in) meningococcal (A39.2-A39.4)
    • sepsis (due to) (in) plague (A20.7)
    • sepsis (due to) (in) tularemia (A21.7)
    • toxic shock syndrome (A48.3)

Diagnosis Index entries containing back-references to A48.3:
  • Shock R57.9
    ICD-10-CM Diagnosis Code R57.9

    Shock, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Failure of peripheral circulation NOS
    • toxic, syndrome A48.3
  • Syndrome - see also Disease
    • shock (traumatic) T79.4
      ICD-10-CM Diagnosis Code T79.4

      Traumatic shock

        2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
      Applicable To
      • Shock (immediate) (delayed) following injury
      Type 1 Excludes
      • anaphylactic shock due to adverse food reaction (T78.0-)
      • anaphylactic shock due to correct medicinal substance properly administered (T88.6)
      • anaphylactic shock due to serum (T80.5-)
      • anaphylactic shock NOS (T78.2)
      • anesthetic shock (T88.2)
      • electric shock (T75.4)
      • nontraumatic shock NEC (R57.-)
      • obstetric shock (O75.1)
      • postprocedural shock (T81.1-)
      • septic shock (R65.21)
      • shock complicating abortion or ectopic or molar pregnancy (O00-O07, O08.3)
      • shock due to lightning (T75.01)
      • shock NOS (R57.9)
      • toxic A48.3
    • toxic shock A48.3
  • Toxic (poisoning) T65.91
    - see also condition
    ICD-10-CM Diagnosis Code T65.91

    Toxic effect of unspecified substance, accidental (unintentional)

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Poisoning NOS
    • shock syndrome A48.3

ICD-10-CM Codes Adjacent To A48.3
A44 Bartonellosis
A44.0 Systemic bartonellosis
A44.1 Cutaneous and mucocutaneous bartonellosis
A44.8 Other forms of bartonellosis
A44.9 Bartonellosis, unspecified
A46 Erysipelas
A48 Other bacterial diseases, not elsewhere classified
A48.0 Gas gangrene
A48.1 Legionnaires' disease
A48.2 Nonpneumonic Legionnaires' disease [Pontiac fever]
A48.3 Toxic shock syndrome
A48.4 Brazilian purpuric fever
A48.5 Other specified botulism
A48.51 Infant botulism
A48.52 Wound botulism
A48.8 Other specified bacterial diseases
A49 Bacterial infection of unspecified site
A49.0 Staphylococcal infection, unspecified site
A49.01 Methicillin susceptible Staphylococcus aureus infection, unspecified site
A49.02 Methicillin resistant Staphylococcus aureus infection, unspecified site
A49.1 Streptococcal infection, unspecified site

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.