2019 ICD-10-CM Diagnosis Code A52.3

Neurosyphilis, unspecified

    2016 2017 2018 2019 Billable/Specific Code
  • A52.3 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2019 edition of ICD-10-CM A52.3 became effective on October 1, 2018.
  • This is the American ICD-10-CM version of A52.3 - other international versions of ICD-10 A52.3 may differ.
Applicable To
  • Gumma (syphilitic)
  • Syphilis (late)
  • Syphiloma
The following code(s) above A52.3 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to A52.3:
  • A00-B99
    2019 ICD-10-CM Range A00-B99

    Certain infectious and parasitic diseases

    Includes
    • diseases generally recognized as communicable or transmissible
    Type 1 Excludes
    • certain localized infections - see body system-related chapters
    Type 2 Excludes
    • carrier or suspected carrier of infectious disease (Z22.-)
    • infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
    • infectious and parasitic diseases specific to the perinatal period (P35-P39)
    • influenza and other acute respiratory infections (J00-J22)
    Use Additional
    • code to identify resistance to antimicrobial drugs (Z16.-)
    Certain infectious and parasitic diseases
  • A50-A64
    2019 ICD-10-CM Range A50-A64

    Infections with a predominantly sexual mode of transmission

    Type 1 Excludes
    • human immunodeficiency virus [HIV] disease (B20)
    • nonspecific and nongonococcal urethritis (N34.1)
    • Reiter's disease (M02.3-)
    Infections with a predominantly sexual mode of transmission
Approximate Synonyms
  • Neurosyphilis
Clinical Information
  • Infection of the brain or spinal cord by treponema pallidum. It occurs many years following the original infection which remained untreated. Signs and symptoms include abnormal gait, blindness, depression, paralysis, seizures and dementia.
  • Infections of the central nervous system caused by treponema pallidum which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as brain infarction. The infection may also remain subclinical for several years. Late syndromes include general paresis; tabes dorsalis; meningeal syphilis; syphilitic optic atrophy; and spinal syphilis. General paresis is characterized by progressive dementia; dysarthria; tremor; myoclonus; seizures; and argyll-robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)
ICD-10-CM A52.3 is grouped within Diagnostic Related Group(s) (MS-DRG v36.0):
  • 056 Degenerative nervous system disorders with mcc
  • 057 Degenerative nervous system disorders without mcc

Convert A52.3 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change

Diagnosis Index entries containing back-references to A52.3:
  • Gumma (syphilitic) A52.79
    ICD-10-CM Diagnosis Code A52.79

    Other symptomatic late syphilis

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Late syphilitic leukoderma
    • Syphilis of adrenal gland
    • Syphilis of pituitary gland
    • Syphilis of thyroid gland
    • Syphilitic splenomegaly
    Type 1 Excludes
    • syphilitic leukoderma (secondary) (A51.39)
    • central nervous system A52.3
    • neurosyphilitic A52.3
  • Neurosyphilis (arrested) (early) (gumma) (late) (latent) (recurrent) (relapse) A52.3
    • remission in A52.3 (sustained)
  • Syphilis, syphilitic (acquired) A53.9
    ICD-10-CM Diagnosis Code A53.9

    Syphilis, unspecified

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Infection due to Treponema pallidum NOS
    • Syphilis (acquired) NOS
    Type 1 Excludes
    • syphilis NOS under two years of age (A50.2)
    • central nervous system (late) (recurrent) (relapse) (tertiary) A52.3
      • remission in A52.3 (sustained)
      • serology doubtful, negative, or positive A52.3
    • early A51.9
      ICD-10-CM Diagnosis Code A51.9

      Early syphilis, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      • central nervous system A52.3
    • gumma NEC A52.79
      ICD-10-CM Diagnosis Code A52.79

      Other symptomatic late syphilis

        2016 2017 2018 2019 Billable/Specific Code
      Applicable To
      • Late syphilitic leukoderma
      • Syphilis of adrenal gland
      • Syphilis of pituitary gland
      • Syphilis of thyroid gland
      • Syphilitic splenomegaly
      Type 1 Excludes
      • syphilitic leukoderma (secondary) (A51.39)
      • central nervous system A52.3
    • late A52.9
      ICD-10-CM Diagnosis Code A52.9

      Late syphilis, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      • central nervous system A52.3
    • primary A51.0
      ICD-10-CM Diagnosis Code A51.0

      Primary genital syphilis

        2016 2017 2018 2019 Billable/Specific Code
      Applicable To
      • Syphilitic chancre NOS
      • central nervous system A52.3
    • tertiary A52.9
      ICD-10-CM Diagnosis Code A52.9

      Late syphilis, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      • central nervous system A52.3
    • nervous system, central A52.3
  • Syphiloma A52.79
    ICD-10-CM Diagnosis Code A52.79

    Other symptomatic late syphilis

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Late syphilitic leukoderma
    • Syphilis of adrenal gland
    • Syphilis of pituitary gland
    • Syphilis of thyroid gland
    • Syphilitic splenomegaly
    Type 1 Excludes
    • syphilitic leukoderma (secondary) (A51.39)
    • central nervous system A52.3

ICD-10-CM Codes Adjacent To A52.3
A52.10 …… unspecified
A52.11 Tabes dorsalis
A52.12 Other cerebrospinal syphilis
A52.13 Late syphilitic meningitis
A52.14 Late syphilitic encephalitis
A52.15 Late syphilitic neuropathy
A52.16 Charcôt's arthropathy (tabetic)
A52.17 General paresis
A52.19 Other symptomatic neurosyphilis
A52.2 Asymptomatic neurosyphilis
A52.3 Neurosyphilis, unspecified
A52.7 Other symptomatic late syphilis
A52.71 Late syphilitic oculopathy
A52.72 Syphilis of lung and bronchus
A52.73 Symptomatic late syphilis of other respiratory organs
A52.74 Syphilis of liver and other viscera
A52.75 Syphilis of kidney and ureter
A52.76 Other genitourinary symptomatic late syphilis
A52.77 Syphilis of bone and joint
A52.78 Syphilis of other musculoskeletal tissue
A52.79 Other symptomatic late syphilis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.