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ICD-10-CM Codes
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A00-B99
Certain infectious and parasitic diseases
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A50-A64
Infections with a predominantly sexual mode of transmission
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A52-
Late syphilis
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2021 ICD-10-CM Diagnosis Code A52.3
2021 ICD-10-CM Diagnosis Code A52.3
Neurosyphilis, unspecified
2016 2017 2018 2019 2020 2021 Billable/Specific Code
- A52.3 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- The 2021 edition of ICD-10-CM A52.3 became effective on October 1, 2020.
- This is the American ICD-10-CM version of A52.3 - other international versions of ICD-10 A52.3 may differ.
Applicable To- Gumma (syphilitic)
- Syphilis (late)
- Syphiloma
The following code(s) above
A52.3 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
A52.3:
- Infection of the brain or spinal cord by treponema pallidum. It occurs many years following the original infection which remained untreated. Signs and symptoms include abnormal gait, blindness, depression, paralysis, seizures and dementia.
- Infections of the central nervous system caused by treponema pallidum which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as brain infarction. The infection may also remain subclinical for several years. Late syndromes include general paresis; tabes dorsalis; meningeal syphilis; syphilitic optic atrophy; and spinal syphilis. General paresis is characterized by progressive dementia; dysarthria; tremor; myoclonus; seizures; and argyll-robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)
ICD-10-CM A52.3 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
- 056 Degenerative nervous system disorders with mcc
- 057 Degenerative nervous system disorders without mcc
Convert A52.3 to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- Gumma (syphilitic) A52.79
ICD-10-CM Diagnosis Code A52.79
Other symptomatic late syphilis
2016 2017 2018 2019 2020 2021 Billable/Specific Code
Applicable To- Late syphilitic leukoderma
- Syphilis of adrenal gland
- Syphilis of pituitary gland
- Syphilis of thyroid gland
- Syphilitic splenomegaly
Type 1 Excludes- syphilitic leukoderma (secondary) (A51.39)
- central nervous system A52.3
- neurosyphilitic A52.3
- Neurosyphilis (arrested) (early) (gumma) (late) (latent) (recurrent) (relapse) A52.3
- remission in A52.3 (sustained)
- Syphilis, syphilitic (acquired) A53.9
ICD-10-CM Diagnosis Code A53.9
Syphilis, unspecified
2016 2017 2018 2019 2020 2021 Billable/Specific Code
Applicable To- Infection due to Treponema pallidum NOS
- Syphilis (acquired) NOS
Type 1 Excludes- syphilis NOS under two years of age (A50.2)
- central nervous system (late) (recurrent) (relapse) (tertiary) A52.3
- remission in A52.3 (sustained)
- serology doubtful, negative, or positive A52.3
- early A51.9
ICD-10-CM Diagnosis Code A51.9
Early syphilis, unspecified
2016 2017 2018 2019 2020 2021 Billable/Specific Code
- central nervous system A52.3
- gumma NEC A52.79
ICD-10-CM Diagnosis Code A52.79
Other symptomatic late syphilis
2016 2017 2018 2019 2020 2021 Billable/Specific Code
Applicable To- Late syphilitic leukoderma
- Syphilis of adrenal gland
- Syphilis of pituitary gland
- Syphilis of thyroid gland
- Syphilitic splenomegaly
Type 1 Excludes- syphilitic leukoderma (secondary) (A51.39)
- central nervous system A52.3
- late A52.9
ICD-10-CM Diagnosis Code A52.9
Late syphilis, unspecified
2016 2017 2018 2019 2020 2021 Billable/Specific Code
- central nervous system A52.3
- primary A51.0
ICD-10-CM Diagnosis Code A51.0
Primary genital syphilis
2016 2017 2018 2019 2020 2021 Billable/Specific Code
- central nervous system A52.3
- tertiary A52.9
ICD-10-CM Diagnosis Code A52.9
Late syphilis, unspecified
2016 2017 2018 2019 2020 2021 Billable/Specific Code
- central nervous system A52.3
- nervous system, central A52.3
- Syphiloma A52.79
ICD-10-CM Diagnosis Code A52.79
Other symptomatic late syphilis
2016 2017 2018 2019 2020 2021 Billable/Specific Code
Applicable To- Late syphilitic leukoderma
- Syphilis of adrenal gland
- Syphilis of pituitary gland
- Syphilis of thyroid gland
- Syphilitic splenomegaly
Type 1 Excludes- syphilitic leukoderma (secondary) (A51.39)
- central nervous system A52.3
ICD-10-CM Codes Adjacent To A52.3
A52.12 Other cerebrospinal syphilis
A52.13 Late syphilitic meningitis
A52.14 Late syphilitic encephalitis
A52.15 Late syphilitic neuropathy
A52.16 Charcôt's arthropathy (tabetic)
A52.19 Other symptomatic neurosyphilis
A52.2 Asymptomatic neurosyphilis
A52.3
Neurosyphilis, unspecified
A52.7 Other symptomatic late syphilis
A52.71 Late syphilitic oculopathy
A52.72 Syphilis of lung and bronchus
A52.73 Symptomatic late syphilis of other respiratory organs
A52.74 Syphilis of liver and other viscera
A52.75 Syphilis of kidney and ureter
A52.76 Other genitourinary symptomatic late syphilis
A52.77 Syphilis of bone and joint
A52.78 Syphilis of other musculoskeletal tissue
A52.79 Other symptomatic late syphilis
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
