2021

  1. ICD-10-CM Codes
    2. ›
  2. C00-D49 Neoplasms
    3. ›
  3. C15-C26 Malignant neoplasms of digestive organs
    4. ›
  4. C22- Malignant neoplasm of liver and intrahepatic bile ducts
    5. ›
  5. 2021 ICD-10-CM Diagnosis Code C22

2021 ICD-10-CM Diagnosis Code C22

Malignant neoplasm of liver and intrahepatic bile ducts

    2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
  • C22 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2021 edition of ICD-10-CM C22 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of C22 - other international versions of ICD-10 C22 may differ.
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code to identify:
  • alcohol abuse and dependence (
    ICD-10-CM Diagnosis Code F10
    • F10 Alcohol related disorders
      • F10.1 Alcohol abuse
        • F10.10 …… uncomplicated
        • F10.11 …… in remission
        • F10.12 Alcohol abuse with intoxication
          • F10.120 Alcohol abuse with intoxication, uncomplicate...
          • F10.121 …… delirium
          • F10.129 …… unspecified
        • F10.13 Alcohol abuse, with withdrawal
          • F10.130 Alcohol abuse with withdrawal, uncomplicated
          • F10.131 Alcohol abuse with withdrawal delirium
          • F10.132 Alcohol abuse with withdrawal with perceptual...
          • F10.139 Alcohol abuse with withdrawal, unspecified
        • F10.14 Alcohol abuse with alcohol-induced mood disor...
        • F10.15 Alcohol abuse with alcohol-induced psychotic ...
          • F10.150 Alcohol abuse with alcohol-induced psychotic ...
          • F10.151 Alcohol abuse with alcohol-induced psychotic ...
          • F10.159 Alcohol abuse with alcohol-induced psychotic ...
        • F10.18 Alcohol abuse with other alcohol-induced diso...
          • F10.180 Alcohol abuse with alcohol-induced anxiety di...
          • F10.181 Alcohol abuse with alcohol-induced sexual dys...
          • F10.182 Alcohol abuse with alcohol-induced sleep diso...
          • F10.188 Alcohol abuse with other alcohol-induced diso...
        • F10.19 Alcohol abuse with unspecified alcohol-induce...
      • F10.2 Alcohol dependence
        • F10.20 …… uncomplicated
        • F10.21 …… in remission
        • F10.22 Alcohol dependence with intoxication
          • F10.220 Alcohol dependence with intoxication, uncompl...
          • F10.221 Alcohol dependence with intoxication delirium...
          • F10.229 Alcohol dependence with intoxication, unspeci...
        • F10.23 Alcohol dependence with withdrawal
          • F10.230 Alcohol dependence with withdrawal, uncomplic...
          • F10.231 …… delirium
          • F10.232 Alcohol dependence with withdrawal with perce...
          • F10.239 Alcohol dependence with withdrawal, unspecifi...
        • F10.24 Alcohol dependence with alcohol-induced mood ...
        • F10.25 Alcohol dependence with alcohol-induced psych...
          • F10.250 Alcohol dependence with alcohol-induced psych...
          • F10.251 Alcohol dependence with alcohol-induced psych...
          • F10.259 Alcohol dependence with alcohol-induced psych...
        • F10.26 Alcohol dependence with alcohol-induced persi...
        • F10.27 Alcohol dependence with alcohol-induced persi...
        • F10.28 Alcohol dependence with other alcohol-induced...
          • F10.280 Alcohol dependence with alcohol-induced anxie...
          • F10.281 Alcohol dependence with alcohol-induced sexua...
          • F10.282 Alcohol dependence with alcohol-induced sleep...
          • F10.288 Alcohol dependence with other alcohol-induced...
        • F10.29 Alcohol dependence with unspecified alcohol-i...
      • F10.9 Alcohol use, unspecified
        • F10.92 Alcohol use, unspecified with intoxication
          • F10.920 Alcohol use, unspecified with intoxication, u...
          • F10.921 Alcohol use, unspecified with intoxication de...
          • F10.929 Alcohol use, unspecified with intoxication, u...
        • F10.93 Alcohol use, unspecified with withdrawal
          • F10.930 Alcohol use, unspecified with withdrawal, unc...
          • F10.931 Alcohol use, unspecified with withdrawal deli...
          • F10.932 Alcohol use, unspecified with withdrawal with...
          • F10.939 Alcohol use, unspecified with withdrawal, uns...
        • F10.94 Alcohol use, unspecified with alcohol-induced...
        • F10.95 Alcohol use, unspecified with alcohol-induced...
          • F10.950 Alcohol use, unspecified with alcohol-induced...
          • F10.951 Alcohol use, unspecified with alcohol-induced...
          • F10.959 Alcohol use, unspecified with alcohol-induced...
        • F10.96 Alcohol use, unspecified with alcohol-induced...
        • F10.97 Alcohol use, unspecified with alcohol-induced...
        • F10.98 Alcohol use, unspecified with other alcohol-i...
          • F10.980 Alcohol use, unspecified with alcohol-induced...
          • F10.981 Alcohol use, unspecified with alcohol-induced...
          • F10.982 Alcohol use, unspecified with alcohol-induced...
          • F10.988 Alcohol use, unspecified with other alcohol-i...
        • F10.99 Alcohol use, unspecified with unspecified alc...
    F10.-
    )
  • hepatitis B (
    ICD-10-CM Diagnosis Code B16
    • B16 Acute hepatitis B
      • B16.0 Acute hepatitis B with delta-agent with hepat...
      • B16.1 Acute hepatitis B with delta-agent without he...
      • B16.2 Acute hepatitis B without delta-agent with he...
      • B16.9 Acute hepatitis B without delta-agent and wit...
    B16.-
    ,
    ICD-10-CM Diagnosis Code B18.0

    Chronic viral hepatitis B with delta-agent

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    B18.0-
    ICD-10-CM Diagnosis Code B18.1

    Chronic viral hepatitis B without delta-agent

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Carrier of viral hepatitis B
    • Chronic (viral) hepatitis B
    B18.1
    )
  • hepatitis C (
    ICD-10-CM Diagnosis Code B17.1

    Acute hepatitis C

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    B17.1-
    ,
    ICD-10-CM Diagnosis Code B18.2

    Chronic viral hepatitis C

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Carrier of viral hepatitis C
    B18.2
    )
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as C22. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • malignant neoplasm of biliary tract NOS (
    ICD-10-CM Diagnosis Code C24.9

    Malignant neoplasm of biliary tract, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    C24.9
    )
  • secondary malignant neoplasm of liver and intrahepatic bile duct (
    ICD-10-CM Diagnosis Code C78.7

    Secondary malignant neoplasm of liver and intrahepatic bile duct

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    C78.7
    )
The following code(s) above C22 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C22:
  • C00-D49
    2021 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • C15-C26
    2021 ICD-10-CM Range C15-C26

    Malignant neoplasms of digestive organs

    Type 1 Excludes
    • Kaposi's sarcoma of gastrointestinal sites (C46.4)
    Type 2 Excludes
    • gastrointestinal stromal tumors (C49.A-)
    Malignant neoplasms of digestive organs
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to C22:
  • Applicable To: Z85.05
    ICD-10-CM Diagnosis Code Z85.05

    Personal history of malignant neoplasm of liver

      2016 2017 2018 2019 2020 2021 Billable/Specific Code POA Exempt
    Applicable To
    • Conditions classifiable to C22
ICD-10-CM Codes Adjacent To C22
C18.7 Malignant neoplasm of sigmoid colon
C18.8 Malignant neoplasm of overlapping sites of colon
C18.9 Malignant neoplasm of colon, unspecified
C19 Malignant neoplasm of rectosigmoid junction
C20 Malignant neoplasm of rectum
C21 Malignant neoplasm of anus and anal canal
C21.0 Malignant neoplasm of anus, unspecified
C21.1 Malignant neoplasm of anal canal
C21.2 Malignant neoplasm of cloacogenic zone
C21.8 Malignant neoplasm of overlapping sites of rectum, anus and anal canal
C22 Malignant neoplasm of liver and intrahepatic bile ducts
C22.0 Liver cell carcinoma
C22.1 Intrahepatic bile duct carcinoma
C22.2 Hepatoblastoma
C22.3 Angiosarcoma of liver
C22.4 Other sarcomas of liver
C22.7 Other specified carcinomas of liver
C22.8 Malignant neoplasm of liver, primary, unspecified as to type
C22.9 Malignant neoplasm of liver, not specified as primary or secondary
C23 Malignant neoplasm of gallbladder
C24 Malignant neoplasm of other and unspecified parts of biliary tract

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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