2020 ICD-10-CM Diagnosis Code C22.1

Intrahepatic bile duct carcinoma

    2016 2017 2018 2019 2020 Billable/Specific Code
  • C22.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM C22.1 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of C22.1 - other international versions of ICD-10 C22.1 may differ.
Applicable To
  • Cholangiocarcinoma
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as C22.1. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • malignant neoplasm of hepatic duct (
    ICD-10-CM Diagnosis Code C24.0

    Malignant neoplasm of extrahepatic bile duct

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Malignant neoplasm of biliary duct or passage NOS
    • Malignant neoplasm of common bile duct
    • Malignant neoplasm of cystic duct
    • Malignant neoplasm of hepatic duct
    C24.0
    )
The following code(s) above C22.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C22.1:
  • C00-D49
    2020 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • C15-C26
    2020 ICD-10-CM Range C15-C26

    Malignant neoplasms of digestive organs

    Type 1 Excludes
    • Kaposi's sarcoma of gastrointestinal sites (C46.4)
    Type 2 Excludes
    • gastrointestinal stromal tumors (C49.A-)
    Malignant neoplasms of digestive organs
  • C22
    ICD-10-CM Diagnosis Code C22

    Malignant neoplasm of liver and intrahepatic bile ducts

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • malignant neoplasm of biliary tract NOS (C24.9)
    • secondary malignant neoplasm of liver and intrahepatic bile duct (C78.7)
    Use Additional
    Malignant neoplasm of liver and intrahepatic bile ducts
Approximate Synonyms
  • Adenocarcinoma, intrahepatic bile duct
  • Cancer of the bile ducts, intrahepatic
  • Cancer of the liver, cholangiocarcinoma
  • Cholangiocarcinoma of biliary tract
  • Malignant neoplasm of intrahepatic gall duct
  • Primary adenocarcinoma of intrahepatic bile duct
Clinical Information
  • (ko-lan-jee-o-sar-ko-ma) a tumor of the connective tissues of the bile ducts.
  • A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
  • A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
  • A malignant neoplasm arising from/comprising cells resembling those of bile ducts.
  • A malignant neoplasm of the liver arising from/comprising cells resembling those of bile ducts.
  • A malignant tumor arising from the intrahepatic bile duct epithelium. It is composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant stroma. (from holland et al., cancer medicine, 3d ed, p1455; stedman, 25th ed)
  • A rare type of cancer that develops in cells that line the bile ducts in the liver. Cancer that forms where the right and left ducts meet is called klatskin tumor.
  • An malignant tumor composed of cells resembling those of bile ducts. Cholangiocarcinoma is a relatively rare tumor in most populations. It can arise from any portion of the intrahepatic bile duct epithelium or the hepatic ducts. Grossly, the lesions are nodular, grayish-white firm and solid. Microscopically, the vast majority of cholangiocarcinomas are adenocarcinomas showing tubular and/or papillary structures. Early detection of cholangiocarcinomas is difficult, and the overall prognosis after resection is poor (adapted from who, 2000).
ICD-10-CM C22.1 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 435 Malignancy of hepatobiliary system or pancreas with mcc
  • 436 Malignancy of hepatobiliary system or pancreas with cc
  • 437 Malignancy of hepatobiliary system or pancreas without cc/mcc

Convert C22.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to C22.1:
  • Type 1 Excludes: C24
    ICD-10-CM Diagnosis Code C24

    Malignant neoplasm of other and unspecified parts of biliary tract

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • malignant neoplasm of intrahepatic bile duct (C22.1)

Diagnosis Index entries containing back-references to C22.1:

ICD-10-CM Codes Adjacent To C22.1
C18.9 Malignant neoplasm of colon, unspecified
C19 Malignant neoplasm of rectosigmoid junction
C20 Malignant neoplasm of rectum
C21 Malignant neoplasm of anus and anal canal
C21.0 Malignant neoplasm of anus, unspecified
C21.1 Malignant neoplasm of anal canal
C21.2 Malignant neoplasm of cloacogenic zone
C21.8 Malignant neoplasm of overlapping sites of rectum, anus and anal canal
C22 Malignant neoplasm of liver and intrahepatic bile ducts
C22.0 Liver cell carcinoma
C22.1 Intrahepatic bile duct carcinoma
C22.2 Hepatoblastoma
C22.3 Angiosarcoma of liver
C22.4 Other sarcomas of liver
C22.7 Other specified carcinomas of liver
C22.8 Malignant neoplasm of liver, primary, unspecified as to type
C22.9 Malignant neoplasm of liver, not specified as primary or secondary
C23 Malignant neoplasm of gallbladder
C24 Malignant neoplasm of other and unspecified parts of biliary tract
C24.0 Malignant neoplasm of extrahepatic bile duct
C24.1 Malignant neoplasm of ampulla of Vater

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.