2019 ICD-10-CM Diagnosis Code C45

Mesothelioma

    2016 2017 2018 2019 Non-Billable/Non-Specific Code
  • C45 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2019 edition of ICD-10-CM C45 became effective on October 1, 2018.
  • This is the American ICD-10-CM version of C45 - other international versions of ICD-10 C45 may differ.
The following code(s) above C45 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C45:
  • C00-D49
    2019 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
Clinical Information
  • A benign (noncancerous) or malignant (cancerous) tumor affecting the lining of the chest or abdomen. Exposure to asbestos particles in the air increases the risk of developing malignant mesothelioma.
  • A benign or malignant tumor affecting the lining of the chest or abdomen
  • A neoplasm originating from mesothelial cells of the pleura or peritoneum, for which the malignancy status has not been established.
  • A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
  • A usually malignant and aggressive neoplasm of the mesothelium which is often associated with exposure to asbestos.
  • Malignant tumor derived from mesothelial tissues of peritoneum, pleura, and pericardium.
  • The tissue that lines your lungs, stomach, heart and other organs is called mesothelium. Mesothelioma is cancer of that tissue. It is a rare but serious type of cancer. It usually starts in the lungs, but can also start in the abdomen or other organs. Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles. It can take a long time - 30 to 50 years - between being around asbestos and getting the disease. Treatment includes surgery, radiation, chemotherapy or all three. nih: national cancer institute
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
Code annotations containing back-references to C45:
  • Type 1 Excludes: C38
    , C48
    ICD-10-CM Diagnosis Code C38

    Malignant neoplasm of heart, mediastinum and pleura

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 1 Excludes
    ICD-10-CM Diagnosis Code C48

    Malignant neoplasm of retroperitoneum and peritoneum

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • Kaposi's sarcoma of connective tissue (C46.1)
    • mesothelioma (C45.-)
  • Type 2 Excludes: C49
    ICD-10-CM Diagnosis Code C49

    Malignant neoplasm of other connective and soft tissue

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Includes
    • malignant neoplasm of blood vessel
    • malignant neoplasm of bursa
    • malignant neoplasm of cartilage
    • malignant neoplasm of fascia
    • malignant neoplasm of fat
    • malignant neoplasm of ligament, except uterine
    • malignant neoplasm of lymphatic vessel
    • malignant neoplasm of muscle
    • malignant neoplasm of synovia
    • malignant neoplasm of tendon (sheath)
    Type 1 Excludes
    • malignant neoplasm of cartilage (of):
    • articular (C40-C41)
    • larynx (C32.3)
    • nose (C30.0)
    • malignant neoplasm of connective tissue of breast (C50.-)
    Type 2 Excludes
    • Kaposi's sarcoma of soft tissue (C46.1)
    • malignant neoplasm of heart (C38.0)
    • malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
    • malignant neoplasm of peritoneum (C48.2)
    • malignant neoplasm of retroperitoneum (C48.0)
    • malignant neoplasm of uterine ligament (C57.3)
    • mesothelioma (C45.-)
ICD-10-CM Codes Adjacent To C45
C44.8 Other and unspecified malignant neoplasm of overlapping sites of skin
C44.80 Unspecified malignant neoplasm of overlapping sites of skin
C44.81 Basal cell carcinoma of overlapping sites of skin
C44.82 Squamous cell carcinoma of overlapping sites of skin
C44.89 Other specified malignant neoplasm of overlapping sites of skin
C44.9 Other and unspecified malignant neoplasm of skin, unspecified
C44.90 Unspecified malignant neoplasm of skin, unspecified
C44.91 Basal cell carcinoma of skin, unspecified
C44.92 Squamous cell carcinoma of skin, unspecified
C44.99 Other specified malignant neoplasm of skin, unspecified
C45 Mesothelioma
C45.0 Mesothelioma of pleura
C45.1 Mesothelioma of peritoneum
C45.2 Mesothelioma of pericardium
C45.7 Mesothelioma of other sites
C45.9 Mesothelioma, unspecified
C46 Kaposi's sarcoma
C46.0 Kaposi's sarcoma of skin
C46.1 Kaposi's sarcoma of soft tissue
C46.2 Kaposi's sarcoma of palate
C46.3 Kaposi's sarcoma of lymph nodes

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.