1. ICD-10-CM Codes
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2. C00-D49 Neoplasms
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3. C45-C49 Malignant neoplasms of mesothelial and soft tissue
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4. C45- Mesothelioma
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5. 2022 ICD-10-CM Diagnosis Code C45.9

2022 ICD-10-CM Diagnosis Code C45.9

Mesothelioma, unspecified

2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code

• C45.9 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2022 edition of ICD-10-CM C45.9 became effective on October 1, 2021.
• This is the American ICD-10-CM version of C45.9 - other international versions of ICD-10 C45.9 may differ.

• Cancer, mesothelioma
• Mesothelioma (malignant, clinical disorder)

• A benign (noncancerous) or malignant (cancerous) tumor affecting the lining of the chest or abdomen. Exposure to asbestos particles in the air increases the risk of developing malignant mesothelioma.
• A benign or malignant tumor affecting the lining of the chest or abdomen
• A neoplasm originating from mesothelial cells of the pleura or peritoneum, for which the malignancy status has not been established.
• A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
• A usually malignant and aggressive neoplasm of the mesothelium which is often associated with exposure to asbestos.
• Malignant tumor derived from mesothelial tissues of peritoneum, pleura, and pericardium.
• The tissue that lines your lungs, stomach, heart and other organs is called mesothelium. Mesothelioma is cancer of that tissue. It is a rare but serious type of cancer. It usually starts in the lungs, but can also start in the abdomen or other organs. Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles. It can take a long time - 30 to 50 years - between being around asbestos and getting the disease. Treatment includes surgery, radiation, chemotherapy or all three. nih: national cancer institute

• 826 Myeloproliferative disorders or poorly differentiated neoplasms with major o.r. Procedures with mcc
• 827 Myeloproliferative disorders or poorly differentiated neoplasms with major o.r. Procedures with cc
• 828 Myeloproliferative disorders or poorly differentiated neoplasms with major o.r. Procedures without cc/mcc
• 829 Myeloproliferative disorders or poorly differentiated neoplasms with other procedures with cc/mcc
• 830 Myeloproliferative disorders or poorly differentiated neoplasms with other procedures without cc/mcc
• 843 Other myeloproliferative disorders or poorly differentiated neoplastic diagnoses with mcc
• 844 Other myeloproliferative disorders or poorly differentiated neoplastic diagnoses with cc
• 845 Other myeloproliferative disorders or poorly differentiated neoplastic diagnoses without cc/mcc

Convert C45.9 to ICD-9-CM

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change

• Mesothelioma (malignant) C45.9
  • biphasic C45.9
  • epithelioid C45.9
  • fibrous C45.9
  • site classification
    • unspecified C45.9

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.