2021

  1. ICD-10-CM Codes
    2. ›
  2. C00-D49 Neoplasms
    3. ›
  3. C45-C49 Malignant neoplasms of mesothelial and soft tissue
    4. ›
  4. C49- Malignant neoplasm of other connective and soft tissue
    5. ›
  5. 2021 ICD-10-CM Diagnosis Code C49.0

2021 ICD-10-CM Diagnosis Code C49.0

Malignant neoplasm of connective and soft tissue of head, face and neck

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • C49.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • Short description: Malig neoplm of conn and soft tissue of head, face and neck
  • The 2021 edition of ICD-10-CM C49.0 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of C49.0 - other international versions of ICD-10 C49.0 may differ.
Applicable To
  • Malignant neoplasm of connective tissue of ear
  • Malignant neoplasm of connective tissue of eyelid
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as C49.0. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • connective tissue of orbit (
    ICD-10-CM Diagnosis Code C69.6

    Malignant neoplasm of orbit

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Applicable To
    • Malignant neoplasm of connective tissue of orbit
    • Malignant neoplasm of extraocular muscle
    • Malignant neoplasm of peripheral nerves of orbit
    • Malignant neoplasm of retrobulbar tissue
    • Malignant neoplasm of retro-ocular tissue
    Type 1 Excludes
    • malignant neoplasm of orbital bone (C41.0)
    C69.6-
    )
The following code(s) above C49.0 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C49.0:
  • C00-D49
    2021 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • C49
    ICD-10-CM Diagnosis Code C49

    Malignant neoplasm of other connective and soft tissue

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Includes
    • malignant neoplasm of blood vessel
    • malignant neoplasm of bursa
    • malignant neoplasm of cartilage
    • malignant neoplasm of fascia
    • malignant neoplasm of fat
    • malignant neoplasm of ligament, except uterine
    • malignant neoplasm of lymphatic vessel
    • malignant neoplasm of muscle
    • malignant neoplasm of synovia
    • malignant neoplasm of tendon (sheath)
    Type 1 Excludes
    • malignant neoplasm of cartilage (of):
    • articular (C40-C41)
    • larynx (C32.3)
    • nose (C30.0)
    • malignant neoplasm of connective tissue of breast (C50.-)
    Type 2 Excludes
    • Kaposi's sarcoma of soft tissue (C46.1)
    • malignant neoplasm of heart (C38.0)
    • malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
    • malignant neoplasm of peritoneum (C48.2)
    • malignant neoplasm of retroperitoneum (C48.0)
    • malignant neoplasm of uterine ligament (C57.3)
    • mesothelioma (C45.-)
    Malignant neoplasm of other connective and soft tissue
Approximate Synonyms
  • Angiosarcoma, face
  • Angiosarcoma, head
  • Angiosarcoma, neck
  • Atypical fibroxanthoma of skin of neck
  • Atypical fibroxanthoma of skin of scalp
  • Cancer of the blood vessel, face
  • Cancer of the blood vessel, head
  • Cancer of the blood vessel, neck
  • Cancer of the muscle, face
  • Cancer of the muscle, head
  • Cancer of the muscle, neck
  • Cancer of the soft tissue, face
  • Cancer of the soft tissue, head
  • Cancer of the soft tissue, neck
  • Cancer of the tongue, sarcoma
  • Fibroxanthoma of neck, atypical
  • Fibroxanthoma of scalp, atypical
  • Leiomyosarcoma, face
  • Leiomyosarcoma, head
  • Leiomyosarcoma, neck
  • Liposarcoma, face
  • Liposarcoma, head
  • Liposarcoma, neck
  • Malignant fibrous histiocytoma, face
  • Malignant fibrous histiocytoma, head
  • Malignant fibrous histiocytoma, neck
  • Primary angiosarcoma of face
  • Primary angiosarcoma of head
  • Primary angiosarcoma of neck
  • Primary leiomyosarcoma of face
  • Primary leiomyosarcoma of head
  • Primary leiomyosarcoma of neck
  • Primary liposarcoma of face
  • Primary liposarcoma of head
  • Primary liposarcoma of neck
  • Primary malignant fibrous histiocytoma of face
  • Primary malignant fibrous histiocytoma of head
  • Primary malignant fibrous histiocytoma of neck
  • Primary malignant neoplasm of blood vessel of face
  • Primary malignant neoplasm of blood vessel of head
  • Primary malignant neoplasm of blood vessel of neck
  • Primary malignant neoplasm of muscle of face
  • Primary malignant neoplasm of muscle of head
  • Primary malignant neoplasm of muscle of neck
  • Primary malignant neoplasm of soft tissues of face
  • Primary malignant neoplasm of soft tissues of head
  • Primary malignant neoplasm of soft tissues of neck
  • Primary rhabdomyosarcoma of face
  • Primary rhabdomyosarcoma of head
  • Primary rhabdomyosarcoma of neck
  • Primary sarcoma of tongue
  • Rhabdomyosarcoma, face
  • Rhabdomyosarcoma, head
  • Rhabdomyosarcoma, neck
  • Sarcoma of face
  • Sarcoma of head
  • Sarcoma of neck
  • Sarcoma, face
  • Sarcoma, head
  • Sarcoma, neck
ICD-10-CM C49.0 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 542 Pathological fractures and musculoskeletal and connective tissue malignancy with mcc
  • 543 Pathological fractures and musculoskeletal and connective tissue malignancy with cc
  • 544 Pathological fractures and musculoskeletal and connective tissue malignancy without cc/mcc

Convert C49.0 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to C49.0:
  • Type 1 Excludes: C30.1
    , C41
    , C41
    , C44.1
    , C44.2
    , C69
    ICD-10-CM Diagnosis Code C30.1

    Malignant neoplasm of middle ear

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Malignant neoplasm of antrum tympanicum
    • Malignant neoplasm of auditory tube
    • Malignant neoplasm of eustachian tube
    • Malignant neoplasm of inner ear
    • Malignant neoplasm of mastoid air cells
    • Malignant neoplasm of tympanic cavity
    Type 1 Excludes
    • malignant neoplasm of auricular canal (external) (C43.2-,C44.2-)
    • malignant neoplasm of bone of ear (meatus) (C41.0)
    • malignant neoplasm of cartilage of ear (C49.0)
    • malignant melanoma of skin of (external) ear (C43.2-)
    • other and unspecified malignant neoplasm of skin of (external) ear (C44.2-)
    ICD-10-CM Diagnosis Code C41

    Malignant neoplasm of bone and articular cartilage of other and unspecified sites

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • malignant neoplasm of bones of limbs (C40.-)
    • malignant neoplasm of cartilage of ear (C49.0)
    • malignant neoplasm of cartilage of eyelid (C49.0)
    • malignant neoplasm of cartilage of larynx (C32.3)
    • malignant neoplasm of cartilage of limbs (C40.-)
    • malignant neoplasm of cartilage of nose (C30.0)
    ICD-10-CM Diagnosis Code C41

    Malignant neoplasm of bone and articular cartilage of other and unspecified sites

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • malignant neoplasm of bones of limbs (C40.-)
    • malignant neoplasm of cartilage of ear (C49.0)
    • malignant neoplasm of cartilage of eyelid (C49.0)
    • malignant neoplasm of cartilage of larynx (C32.3)
    • malignant neoplasm of cartilage of limbs (C40.-)
    • malignant neoplasm of cartilage of nose (C30.0)
    ICD-10-CM Diagnosis Code C44.1

    Other and unspecified malignant neoplasm of skin of eyelid, including canthus

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • connective tissue of eyelid (C49.0)
    ICD-10-CM Diagnosis Code C44.2

    Other and unspecified malignant neoplasm of skin of ear and external auricular canal

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • connective tissue of ear (C49.0)
    ICD-10-CM Diagnosis Code C69

    Malignant neoplasm of eye and adnexa

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • malignant neoplasm of connective tissue of eyelid (C49.0)
    • malignant neoplasm of eyelid (skin) (C43.1-, C44.1-)
    • malignant neoplasm of optic nerve (C72.3-)
ICD-10-CM Codes Adjacent To C49.0
C47.5 Malignant neoplasm of peripheral nerves of pelvis
C47.6 Malignant neoplasm of peripheral nerves of trunk, unspecified
C47.8 Malignant neoplasm of overlapping sites of peripheral nerves and autonomic nervous system
C47.9 Malignant neoplasm of peripheral nerves and autonomic nervous system, unspecified
C48 Malignant neoplasm of retroperitoneum and peritoneum
C48.0 Malignant neoplasm of retroperitoneum
C48.1 Malignant neoplasm of specified parts of peritoneum
C48.2 Malignant neoplasm of peritoneum, unspecified
C48.8 Malignant neoplasm of overlapping sites of retroperitoneum and peritoneum
C49 Malignant neoplasm of other connective and soft tissue
C49.0 Malignant neoplasm of connective and soft tissue of head, face and neck
C49.1 Malignant neoplasm of connective and soft tissue of upper limb, including shoulder
C49.10 Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
C49.11 Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder
C49.12 Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
C49.2 Malignant neoplasm of connective and soft tissue of lower limb, including hip
C49.20 Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
C49.21 Malignant neoplasm of connective and soft tissue of right lower limb, including hip
C49.22 Malignant neoplasm of connective and soft tissue of left lower limb, including hip
C49.3 Malignant neoplasm of connective and soft tissue of thorax
C49.4 Malignant neoplasm of connective and soft tissue of abdomen

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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