ICD-10-CM Codes
C00-D49 Neoplasms
C50-C50 Malignant neoplasms of breast
C50- Malignant neoplasm of breast
2021 ICD-10-CM Diagnosis Code C50

2021 ICD-10-CM Diagnosis Code C50

Malignant neoplasm of breast

2016

2017

2018

2019

2020

2021

Non-Billable/Non-Specific Code

C50 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
The 2021 edition of ICD-10-CM C50 became effective on October 1, 2020.
This is the American ICD-10-CM version of C50 - other international versions of ICD-10 C50 may differ.

Use Additional

Use Additional Help

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.

code to identify estrogen receptor status (
ICD-10-CM Diagnosis Code Z17.0
Estrogen receptor positive status [ER+]
Z17.0
,
ICD-10-CM Diagnosis Code Z17.1
Estrogen receptor negative status [ER-]
Z17.1
)

Type 1 Excludes

Type 1 Excludes Help

A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as C50. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

skin of breast (
ICD-10-CM Diagnosis Code C44.501
Unspecified malignant neoplasm of skin of breast
C44.501
,
ICD-10-CM Diagnosis Code C44.511
Basal cell carcinoma of skin of breast
C44.511
,
ICD-10-CM Diagnosis Code C44.521
Squamous cell carcinoma of skin of breast
C44.521
,
ICD-10-CM Diagnosis Code C44.591
Other specified malignant neoplasm of skin of breast
C44.591
)

Includes

Includes Help

"Includes" further defines, or give examples of, the content of the code or category.

connective tissue of breast
Paget's disease of breast
Paget's disease of nipple

The following code(s) above C50 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to C50:

C00-D49
2021 ICD-10-CM Range C00-D49
Neoplasms
Note
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Neoplasms

Clinical Information

A form of breast cancer in which the tumor grows from ducts beneath the nipple onto the surface of the nipple. Symptoms commonly include itching and burning and an eczema-like condition around the nipple, sometimes accompanied by oozing or bleeding.
A malignant epithelial cellular proliferation characterized by the presence of atypical cells with large nuclei and abundant pale cytoplasm within the squamous epithelium of the nipple. In almost all cases there is an underlying intraductal breast carcinoma or intraductal and invasive carcinoma. The skin changes range from redness to eczematous appearance.
A malignant neoplasm in which there is infiltration of the skin overlying the breast by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (paget cells). It is almost always associated with an intraductal or invasive ductal carcinoma of the breast. The clinical features include focal skin reddening, and eczema. Retraction of the nipple may sometimes occur.
A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males.
An intraductal carcinoma of the breast extending to involve the nipple and areola, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (paget's cells). (Dorland, 27th ed)
Breast cancer affects one in eight women during their lives. Breast cancer kills more women in the United States than any cancer except lung cancer. No one knows why some women get breast cancer, but there are a number of risk factors. Risks that you cannot change include
- age - the chance of getting breast cancer rises as a woman gets older
- genes - there are two genes, brca1 and brca2, that greatly increase the risk. Women who have family members with breast or ovarian cancer may wish to be tested.
- personal factors - beginning periods before age 12 or going through menopause after age 55
other risks include being overweight, using hormone replacement therapy (also called menopausal hormone therapy), taking birth control pills, drinking alcohol, not having children or having your first child after age 35 or having dense breasts.symptoms of breast cancer may include a lump in the breast, a change in size or shape of the breast or discharge from a nipple. Breast self-exam and mammography can help find breast cancer early when it is most treatable. Treatment may consist of radiation, lumpectomy, mastectomy, chemotherapy and hormone therapy.men can have breast cancer, too, but the number of cases is small. nih: national cancer institute
Carcinoma of the breast extending to involve the nipple and areola, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells.

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change

Code annotations containing back-references to C50:

Code Also: D61.82

ICD-10-CM Diagnosis Code D61.82
Myelophthisis
Applicable To
- Leukoerythroblastic anemia
- Myelophthisic anemia
- Panmyelophthisis
Code Also
- the underlying disorder, such as:
- malignant neoplasm of breast (C50.-)
- tuberculosis (A15.-)
Type 1 Excludes
- idiopathic myelofibrosis (D47.1)
- myelofibrosis NOS (D75.81)
- myelofibrosis with myeloid metaplasia (D47.4)
- primary myelofibrosis (D47.1)
- secondary myelofibrosis (D75.81)
Code First: D75.81
, Z17
, Z79.81

ICD-10-CM Diagnosis Code D75.81
Myelofibrosis
Applicable To
- Myelofibrosis NOS
- Secondary myelofibrosis NOS
Code First
- the underlying disorder, such as:
- malignant neoplasm of breast (C50.-)
Type 1 Excludes
- acute myelofibrosis (C94.4-)
- idiopathic myelofibrosis (D47.1)
- leukoerythroblastic anemia (D61.82)
- myelofibrosis with myeloid metaplasia (D47.4)
- myelophthisic anemia (D61.82)
- myelophthisis (D61.82)
- primary myelofibrosis (D47.1)
Use Additional
- code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
ICD-10-CM Diagnosis Code Z17
Estrogen receptor status
Code First
- malignant neoplasm of breast (C50.-)
ICD-10-CM Diagnosis Code Z79.81
Long term (current) use of agents affecting estrogen receptors and estrogen levels
Code First
- , if applicable:
- malignant neoplasm of breast (C50.-)
- malignant neoplasm of prostate (C61)
Type 1 Excludes
- hormone replacement therapy (Z79.890)
Use Additional
- code, if applicable, to identify:
- estrogen receptor positive status (Z17.0)
- family history of breast cancer (Z80.3)
- genetic susceptibility to malignant neoplasm (cancer) (Z15.0-)
- personal history of breast cancer (Z85.3)
- personal history of prostate cancer (Z85.46)
- postmenopausal status (Z78.0)
Type 1 Excludes: C49
, C49.3
, D05

ICD-10-CM Diagnosis Code C49
Malignant neoplasm of other connective and soft tissue
Includes
- malignant neoplasm of blood vessel
- malignant neoplasm of bursa
- malignant neoplasm of cartilage
- malignant neoplasm of fascia
- malignant neoplasm of fat
- malignant neoplasm of ligament, except uterine
- malignant neoplasm of lymphatic vessel
- malignant neoplasm of muscle
- malignant neoplasm of synovia
- malignant neoplasm of tendon (sheath)
Type 1 Excludes
- malignant neoplasm of cartilage (of):
- articular (C40-C41)
- larynx (C32.3)
- nose (C30.0)
- malignant neoplasm of connective tissue of breast (C50.-)
Type 2 Excludes
- Kaposi's sarcoma of soft tissue (C46.1)
- malignant neoplasm of heart (C38.0)
- malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
- malignant neoplasm of peritoneum (C48.2)
- malignant neoplasm of retroperitoneum (C48.0)
- malignant neoplasm of uterine ligament (C57.3)
- mesothelioma (C45.-)
ICD-10-CM Diagnosis Code C49.3
Malignant neoplasm of connective and soft tissue of thorax
Applicable To
- Malignant neoplasm of axilla
- Malignant neoplasm of diaphragm
- Malignant neoplasm of great vessels
Type 1 Excludes
- malignant neoplasm of breast (C50.-)
- malignant neoplasm of heart (C38.0)
- malignant neoplasm of mediastinum (C38.1-C38.3)
- malignant neoplasm of thymus (C37)
ICD-10-CM Diagnosis Code D05
Carcinoma in situ of breast
Type 1 Excludes
- carcinoma in situ of skin of breast (D04.5)
- melanoma in situ of breast (skin) (D03.5)
- Paget's disease of breast or nipple (C50.-)
Applicable To: Z80.3
, Z85.3

ICD-10-CM Diagnosis Code Z80.3
Family history of malignant neoplasm of breast
Applicable To
- Conditions classifiable to C50.-
ICD-10-CM Diagnosis Code Z85.3
Personal history of malignant neoplasm of breast
Applicable To
- Conditions classifiable to C50.-

ICD-10-CM Codes Adjacent To C50

C49.8 Malignant neoplasm of overlapping sites of connective and soft tissue

C49.9 Malignant neoplasm of connective and soft tissue, unspecified

C49.A Gastrointestinal stromal tumor

C49.A0 …… unspecified site

C49.A1 …… of esophagus

C49.A2 …… of stomach

C49.A3 …… of small intestine

C49.A4 …… of large intestine

C49.A5 …… of rectum

C49.A9 …… of other sites

C50 Malignant neoplasm of breast

C50.0 Malignant neoplasm of nipple and areola

C50.01 Malignant neoplasm of nipple and areola, female

C50.011 Malignant neoplasm of nipple and areola, right female breast

C50.012 Malignant neoplasm of nipple and areola, left female breast

C50.019 Malignant neoplasm of nipple and areola, unspecified female breast

C50.02 Malignant neoplasm of nipple and areola, male

C50.021 Malignant neoplasm of nipple and areola, right male breast

C50.022 Malignant neoplasm of nipple and areola, left male breast

C50.029 Malignant neoplasm of nipple and areola, unspecified male breast

C50.1 Malignant neoplasm of central portion of breast

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2021 ICD-10-CM Diagnosis Code C50

Malignant neoplasm of breast

Estrogen receptor positive status [ER+]

Estrogen receptor negative status [ER-]

Unspecified malignant neoplasm of skin of breast

Basal cell carcinoma of skin of breast

Squamous cell carcinoma of skin of breast

Other specified malignant neoplasm of skin of breast

Neoplasms

Myelophthisis

Myelofibrosis

Estrogen receptor status

Long term (current) use of agents affecting estrogen receptors and estrogen levels

Malignant neoplasm of other connective and soft tissue

Malignant neoplasm of connective and soft tissue of thorax

Carcinoma in situ of breast

Family history of malignant neoplasm of breast

Personal history of malignant neoplasm of breast