2023 ICD-10-CM Diagnosis Code C81.0

Nodular lymphocyte predominant Hodgkin lymphoma

    2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
  • C81.0 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2023 edition of ICD-10-CM C81.0 became effective on October 1, 2022.
  • This is the American ICD-10-CM version of C81.0 - other international versions of ICD-10 C81.0 may differ.
The following code(s) above C81.0 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C81.0:
  • C00-D49
    2023 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • C81-C96
    2023 ICD-10-CM Range C81-C96

    Malignant neoplasms of lymphoid, hematopoietic and related tissue

    Type 2 Excludes
    • Kaposi's sarcoma of lymph nodes (C46.3)
    • secondary and unspecified neoplasm of lymph nodes (C77.-)
    • secondary neoplasm of bone marrow (C79.52)
    • secondary neoplasm of spleen (C78.89)
    Malignant neoplasms of lymphoid, hematopoietic and related tissue
  • C81
    ICD-10-CM Diagnosis Code C81

    Hodgkin lymphoma

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • personal history of Hodgkin lymphoma (Z85.71)
    Hodgkin lymphoma
Clinical Information
  • A monoclonal b-cell neoplasm characterized by a nodular, or a nodular and diffuse, polymorphous proliferation of scattered large neoplastic cells known as popcorn or l&h cells; the l&h cells are cd15 negative, and rarely positive for cd30 antigen. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage i or ii); the prognosis of patients with stage i and stage ii disease is very good. Advanced stages have an unfavorable prognosis.
  • A rare type of hodgkin lymphoma, which is a cancer of the immune system. It is marked by the presence of a type of cell called a popcorn cell, which is different from the typical reed-sternberg cell found in classical hodgkin lymphoma. This type of hodgkin lymphoma may change into diffuse large b-cell lymphoma.
  • A subtype of classical hodgkin lymphoma. Most patients present with peripheral lymphadenopathy and limited stage disease (stage i or ii). The survival and progression free survival are slightly better than in other subtypes of classical hodgkin lymphoma. (who, 2001)
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
Code annotations containing back-references to C81.0:
  • Code First: N16
    ICD-10-CM Diagnosis Code N16

    Renal tubulo-interstitial disorders in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code Manifestation Code
    Applicable To
    • Pyelonephritis
    • Tubulo-interstitial nephritis
    Code First
    Type 1 Excludes
    • diphtheritic pyelonephritis and tubulo-interstitial nephritis (A36.84)
    • pyelonephritis and tubulo-interstitial nephritis in candidiasis (B37.49)
    • pyelonephritis and tubulo-interstitial nephritis in cystinosis (E72.04)
    • pyelonephritis and tubulo-interstitial nephritis in salmonella infection (A02.25)
    • pyelonephritis and tubulo-interstitial nephritis in sarcoidosis (D86.84)
    • pyelonephritis and tubulo-interstitial nephritis in Sjogren syndrome (M35.04)
    • pyelonephritis and tubulo-interstitial nephritis in systemic lupus erythematosus (M32.15)
    • pyelonephritis and tubulo-interstitial nephritis in toxoplasmosis (B58.83)
    • renal tubular degeneration in diabetes (E08-E13 with .29)
    • syphilitic pyelonephritis and tubulo-interstitial nephritis (A52.75)
  • Type 1 Excludes: C81.4
    ICD-10-CM Diagnosis Code C81.4

    Lymphocyte-rich Hodgkin lymphoma

      2016 2017 - Revised Code 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Applicable To
    • Lymphocyte-rich classical Hodgkin lymphoma
    Type 1 Excludes
    • nodular lymphocyte predominant Hodgkin lymphoma (C81.0-)

Diagnosis Index entries containing back-references to C81.0:
  • Lymphoma (of) (malignant) C85.90
    ICD-10-CM Diagnosis Code C85.90

    Non-Hodgkin lymphoma, unspecified, unspecified site

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    • Hodgkin C81.9
      ICD-10-CM Diagnosis Code C81.9

      Hodgkin lymphoma, unspecified

        2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
      • nodular
        • lymphocyte predominant C81.0-

ICD-10-CM Codes Adjacent To C81.0
C79.8 Secondary malignant neoplasm of other specified sites
C79.81 Secondary malignant neoplasm of breast
C79.82 Secondary malignant neoplasm of genital organs
C79.89 Secondary malignant neoplasm of other specified sites
C79.9 Secondary malignant neoplasm of unspecified site
C80 Malignant neoplasm without specification of site
C80.0 Disseminated malignant neoplasm, unspecified
C80.1 Malignant (primary) neoplasm, unspecified
C80.2 Malignant neoplasm associated with transplanted organ
C81 Hodgkin lymphoma
C81.0 Nodular lymphocyte predominant Hodgkin lymphoma
C81.00 …… unspecified site
C81.01 …… lymph nodes of head, face, and neck
C81.02 …… intrathoracic lymph nodes
C81.03 …… intra-abdominal lymph nodes
C81.04 …… lymph nodes of axilla and upper limb
C81.05 …… lymph nodes of inguinal region and lower limb
C81.06 …… intrapelvic lymph nodes
C81.07 …… spleen
C81.08 …… lymph nodes of multiple sites
C81.09 …… extranodal and solid organ sites

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.