2020 ICD-10-CM Diagnosis Code C83.3

Diffuse large B-cell lymphoma

    2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
  • C83.3 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2020 edition of ICD-10-CM C83.3 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of C83.3 - other international versions of ICD-10 C83.3 may differ.
Applicable To
  • Anaplastic diffuse large B-cell lymphoma
  • CD30-positive diffuse large B-cell lymphoma
  • Centroblastic diffuse large B-cell lymphoma
  • Diffuse large B-cell lymphoma, subtype not specified
  • Immunoblastic diffuse large B-cell lymphoma
  • Plasmablastic diffuse large B-cell lymphoma
  • Diffuse large B-cell lymphoma, subtype not specified
  • T-cell rich diffuse large B-cell lymphoma
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as C83.3. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • mediastinal (thymic) large B-cell lymphoma (
    ICD-10-CM Diagnosis Code C85.2

    Mediastinal (thymic) large B-cell lymphoma

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    C85.2-
    )
  • mature T/NK-cell lymphomas (
    ICD-10-CM Diagnosis Code C84
    • C84 Mature T/NK-cell lymphomas
      • C84.0 Mycosis fungoides
        • C84.00 …… unspecified site
        • C84.01 Mycosis fungoides, lymph nodes of head, face,...
        • C84.02 …… intrathoracic lymph nodes
        • C84.03 Mycosis fungoides, intra-abdominal lymph node...
        • C84.04 Mycosis fungoides, lymph nodes of axilla and ...
        • C84.05 Mycosis fungoides, lymph nodes of inguinal re...
        • C84.06 …… intrapelvic lymph nodes
        • C84.07 …… spleen
        • C84.08 Mycosis fungoides, lymph nodes of multiple si...
        • C84.09 Mycosis fungoides, extranodal and solid organ...
      • C84.1 Sézary disease
        • C84.10 …… unspecified site
        • C84.11 Sézary disease, lymph nodes of head, face, an...
        • C84.12 …… intrathoracic lymph nodes
        • C84.13 …… intra-abdominal lymph nodes
        • C84.14 Sézary disease, lymph nodes of axilla and upp...
        • C84.15 Sézary disease, lymph nodes of inguinal regio...
        • C84.16 …… intrapelvic lymph nodes
        • C84.17 …… spleen
        • C84.18 Sézary disease, lymph nodes of multiple sites...
        • C84.19 Sézary disease, extranodal and solid organ si...
      • C84.4 Peripheral T-cell lymphoma, not classified
        • C84.40 Peripheral T-cell lymphoma, not classified, u...
        • C84.41 Peripheral T-cell lymphoma, not classified, l...
        • C84.42 Peripheral T-cell lymphoma, not classified, i...
        • C84.43 Peripheral T-cell lymphoma, not classified, i...
        • C84.44 Peripheral T-cell lymphoma, not classified, l...
        • C84.45 Peripheral T-cell lymphoma, not classified, l...
        • C84.46 Peripheral T-cell lymphoma, not classified, i...
        • C84.47 Peripheral T-cell lymphoma, not classified, s...
        • C84.48 Peripheral T-cell lymphoma, not classified, l...
        • C84.49 Peripheral T-cell lymphoma, not classified, e...
      • C84.6 Anaplastic large cell lymphoma, ALK-positive
        • C84.60 Anaplastic large cell lymphoma, ALK-positive,...
        • C84.61 Anaplastic large cell lymphoma, ALK-positive,...
        • C84.62 Anaplastic large cell lymphoma, ALK-positive,...
        • C84.63 Anaplastic large cell lymphoma, ALK-positive,...
        • C84.64 Anaplastic large cell lymphoma, ALK-positive,...
        • C84.65 Anaplastic large cell lymphoma, ALK-positive,...
        • C84.66 Anaplastic large cell lymphoma, ALK-positive,...
        • C84.67 Anaplastic large cell lymphoma, ALK-positive,...
        • C84.68 Anaplastic large cell lymphoma, ALK-positive,...
        • C84.69 Anaplastic large cell lymphoma, ALK-positive,...
      • C84.7 Anaplastic large cell lymphoma, ALK-negative
        • C84.70 Anaplastic large cell lymphoma, ALK-negative,...
        • C84.71 Anaplastic large cell lymphoma, ALK-negative,...
        • C84.72 Anaplastic large cell lymphoma, ALK-negative,...
        • C84.73 Anaplastic large cell lymphoma, ALK-negative,...
        • C84.74 Anaplastic large cell lymphoma, ALK-negative,...
        • C84.75 Anaplastic large cell lymphoma, ALK-negative,...
        • C84.76 Anaplastic large cell lymphoma, ALK-negative,...
        • C84.77 Anaplastic large cell lymphoma, ALK-negative,...
        • C84.78 Anaplastic large cell lymphoma, ALK-negative,...
        • C84.79 Anaplastic large cell lymphoma, ALK-negative,...
      • C84.A Cutaneous T-cell lymphoma, unspecified
        • C84.A0 Cutaneous T-cell lymphoma, unspecified, unspe...
        • C84.A1 Cutaneous T-cell lymphoma, unspecified lymph ...
        • C84.A2 Cutaneous T-cell lymphoma, unspecified, intra...
        • C84.A3 Cutaneous T-cell lymphoma, unspecified, intra...
        • C84.A4 Cutaneous T-cell lymphoma, unspecified, lymph...
        • C84.A5 Cutaneous T-cell lymphoma, unspecified, lymph...
        • C84.A6 Cutaneous T-cell lymphoma, unspecified, intra...
        • C84.A7 Cutaneous T-cell lymphoma, unspecified, splee...
        • C84.A8 Cutaneous T-cell lymphoma, unspecified, lymph...
        • C84.A9 Cutaneous T-cell lymphoma, unspecified, extra...
      • C84.Z Other mature T/NK-cell lymphomas
        • C84.Z0 Other mature T/NK-cell lymphomas, unspecified...
        • C84.Z1 Other mature T/NK-cell lymphomas, lymph nodes...
        • C84.Z2 Other mature T/NK-cell lymphomas, intrathorac...
        • C84.Z3 Other mature T/NK-cell lymphomas, intra-abdom...
        • C84.Z4 Other mature T/NK-cell lymphomas, lymph nodes...
        • C84.Z5 Other mature T/NK-cell lymphomas, lymph nodes...
        • C84.Z6 Other mature T/NK-cell lymphomas, intrapelvic...
        • C84.Z7 …… spleen
        • C84.Z8 Other mature T/NK-cell lymphomas, lymph nodes...
        • C84.Z9 Other mature T/NK-cell lymphomas, extranodal ...
      • C84.9 Mature T/NK-cell lymphomas, unspecified
        • C84.90 Mature T/NK-cell lymphomas, unspecified, unsp...
        • C84.91 Mature T/NK-cell lymphomas, unspecified, lymp...
        • C84.92 Mature T/NK-cell lymphomas, unspecified, intr...
        • C84.93 Mature T/NK-cell lymphomas, unspecified, intr...
        • C84.94 Mature T/NK-cell lymphomas, unspecified, lymp...
        • C84.95 Mature T/NK-cell lymphomas, unspecified, lymp...
        • C84.96 Mature T/NK-cell lymphomas, unspecified, intr...
        • C84.97 Mature T/NK-cell lymphomas, unspecified, sple...
        • C84.98 Mature T/NK-cell lymphomas, unspecified, lymp...
        • C84.99 Mature T/NK-cell lymphomas, unspecified, extr...
    C84.-
    )
The following code(s) above C83.3 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C83.3:
  • C00-D49
    2020 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • C81-C96
    2020 ICD-10-CM Range C81-C96

    Malignant neoplasms of lymphoid, hematopoietic and related tissue

    Type 2 Excludes
    • Kaposi's sarcoma of lymph nodes (C46.3)
    • secondary and unspecified neoplasm of lymph nodes (C77.-)
    • secondary neoplasm of bone marrow (C79.52)
    • secondary neoplasm of spleen (C78.89)
    Malignant neoplasms of lymphoid, hematopoietic and related tissue
  • C83
    ICD-10-CM Diagnosis Code C83

    Non-follicular lymphoma

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • personal history of non-Hodgkin lymphoma (Z85.72)
    Non-follicular lymphoma
Clinical Information
  • A non-hodgkin lymphoma characterized by a diffuse proliferation of predominantly large neoplastic b lymphocytes. It is the most frequently seen type of non-hodgkin lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities include t-cell/histiocyte rich large b-cell lymphoma, primary diffuse large b-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary cutaneous diffuse large b-cell lymphoma, leg type, and alk-positive large b-cell lymphoma.
  • A non-hodgkin lymphoma characterized by a diffuse proliferation of predominantly large neoplastic b lymphocytes. It is the most frequently seen type of non-hodgkin lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, t-cell/histiocyte rich lymphoma, anaplastic lymphoma, plasmablastic lymphoma, and diffuse large b-cell lymphoma with expression of full-length alk. (who, 2001)
  • A type of b-cell non-hodgkin lymphoma (cancer of the immune system) that is usually aggressive (fast-growing). It is the most common type of non-hodgkin lymphoma, and is marked by rapidly growing tumors in the lymph nodes, spleen, liver, bone marrow, or other organs. Other symptoms include fever, night sweats, and weight loss. There are several subtypes of diffuse large b-cell lymphoma.
  • Malignant lymphoma composed of large b lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of b-lymphocytes at midstage in the process of differentiation.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to C83.3:
  • Type 1 Excludes: C83.8
    , C88.4
    ICD-10-CM Diagnosis Code C83.8

    Other non-follicular lymphoma

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Intravascular large B-cell lymphoma
    • Lymphoid granulomatosis
    • Primary effusion B-cell lymphoma
    Type 1 Excludes
    • mediastinal (thymic) large B-cell lymphoma (C85.2-)
    • T-cell rich B-cell lymphoma (C83.3-)
    ICD-10-CM Diagnosis Code C88.4

    Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Lymphoma of skin-associated lymphoid tissue [SALT-lymphoma]
    • Lymphoma of bronchial-associated lymphoid tissue [BALT-lymphoma]
    Type 1 Excludes
    • high malignant (diffuse large B-cell) lymphoma (C83.3-)

Diagnosis Index entries containing back-references to C83.3:
  • Lymphoma (of) (malignant) C85.90
    ICD-10-CM Diagnosis Code C85.90

    Non-Hodgkin lymphoma, unspecified, unspecified site

      2016 2017 2018 2019 2020 Billable/Specific Code
    • diffuse large cell C83.3-
      • anaplastic C83.3-
      • B-cell C83.3-
      • CD30-positive C83.3-
      • centroblastic C83.3-
      • immunoblastic C83.3-
      • plasmablastic C83.3-
      • subtype not specified C83.3-
      • T-cell rich C83.3-

ICD-10-CM Codes Adjacent To C83.3
C83.10 …… unspecified site
C83.11 …… lymph nodes of head, face, and neck
C83.12 …… intrathoracic lymph nodes
C83.13 …… intra-abdominal lymph nodes
C83.14 …… lymph nodes of axilla and upper limb
C83.15 …… lymph nodes of inguinal region and lower limb
C83.16 …… intrapelvic lymph nodes
C83.17 …… spleen
C83.18 …… lymph nodes of multiple sites
C83.19 …… extranodal and solid organ sites
C83.3 Diffuse large B-cell lymphoma
C83.30 …… unspecified site
C83.31 …… lymph nodes of head, face, and neck
C83.32 …… intrathoracic lymph nodes
C83.33 …… intra-abdominal lymph nodes
C83.34 …… lymph nodes of axilla and upper limb
C83.35 …… lymph nodes of inguinal region and lower limb
C83.36 …… intrapelvic lymph nodes
C83.37 …… spleen
C83.38 …… lymph nodes of multiple sites
C83.39 …… extranodal and solid organ sites

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.