2019 ICD-10-CM Diagnosis Code C91.1

Chronic lymphocytic leukemia of B-cell type

    2016 2017 2018 2019 Non-Billable/Non-Specific Code
  • C91.1 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2019 edition of ICD-10-CM C91.1 became effective on October 1, 2018.
  • This is the American ICD-10-CM version of C91.1 - other international versions of ICD-10 C91.1 may differ.
Applicable To
  • Lymphoplasmacytic leukemia
  • Richter syndrome
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as C91.1. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • lymphoplasmacytic lymphoma (
    ICD-10-CM Diagnosis Code C83.0

    Small cell B-cell lymphoma

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Applicable To
    • Lymphoplasmacytic lymphoma
    • Nodal marginal zone lymphoma
    • Non-leukemic variant of B-CLL
    • Splenic marginal zone lymphoma
    Type 1 Excludes
    • chronic lymphocytic leukemia (C91.1)
    • mature T/NK-cell lymphomas (C84.-)
    • Waldenström macroglobulinemia (C88.0)
    C83.0-
    )
The following code(s) above C91.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C91.1:
  • C00-D49
    2019 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • C81-C96
    2019 ICD-10-CM Range C81-C96

    Malignant neoplasms of lymphoid, hematopoietic and related tissue

    Type 2 Excludes
    • Kaposi's sarcoma of lymph nodes (C46.3)
    • secondary and unspecified neoplasm of lymph nodes (C77.-)
    • secondary neoplasm of bone marrow (C79.52)
    • secondary neoplasm of spleen (C78.89)
    Malignant neoplasms of lymphoid, hematopoietic and related tissue
  • C91
    ICD-10-CM Diagnosis Code C91

    Lymphoid leukemia

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • personal history of leukemia (Z85.6)
    Lymphoid leukemia
Clinical Information
  • A chronic leukemia characterized by abnormal b-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (cll); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.
  • A rare condition in which chronic lymphocytic leukemia (cll) changes into a fast-growing type of lymphoma. Symptoms of richter syndrome include fever, loss of weight and muscle mass, and other health problems.
  • An indolent (slow-growing) cancer in which too many immature lymphocytes (white blood cells) are found mostly in the blood and bone marrow. Sometimes, in later stages of the disease, cancer cells are found in the lymph nodes and the disease is called small lymphocytic lymphoma.
  • Chronic leukemia characterized by morphologically mature but immunologically less mature lymphocytes; manifested by an abnormal accumulation of these cells in blood, bone marrow, and lymphatic tissue.
  • leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In chronic lymphocytic leukemia (cll), there are too many lymphocytes, a type of white blood cell.cll is the second most common type of leukemia in adults. It often occurs during or after middle age, and is rare in children.usually cll does not cause any symptoms. If you have symptoms, they may include
    • painless swelling of the lymph nodes in the neck, underarm, stomach, or groin
    • fatigue
    • pain or a feeling of fullness below the ribs
    • fever and infection
    • weight loss
    tests that examine the blood, bone marrow, and lymph nodes diagnose cll. Your doctor may choose to just monitor you until symptoms appear or change. Treatments include radiation therapy, chemotherapy, surgery to remove the spleen, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute
  • The most common type of chronic lymphoid leukemia. It comprises 90% of chronic lymphoid leukemias in the United States. Morphologically, the neoplastic cells are small, round b-lymphocytes. This type of leukemia is not considered to be curable with available therapy. (who, 2001)
  • Transformation of chronic lymphocytic leukemia into aggressive non-hodgkin's lymphoma, usually diffuse large b-cell lymphoma (immunoblastic or centroblastic variant). Occasional cases of transformation to hodgkin's lymphoma have also been described, particularly in patients treated with purine nucleotide analogues. Molecular genetic studies suggest that in approximately half of the cases, the lymphoma is clonally related to the underlying chronic lymphocytic leukemia, whereas in the remaining cases the lymphoma probably represents a secondary, unrelated neoplasm.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
Code annotations containing back-references to C91.1:
  • Type 1 Excludes: C83.0
    , C84.Z
    ICD-10-CM Diagnosis Code C83.0

    Small cell B-cell lymphoma

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Applicable To
    • Lymphoplasmacytic lymphoma
    • Nodal marginal zone lymphoma
    • Non-leukemic variant of B-CLL
    • Splenic marginal zone lymphoma
    Type 1 Excludes
    • chronic lymphocytic leukemia (C91.1)
    • mature T/NK-cell lymphomas (C84.-)
    • Waldenström macroglobulinemia (C88.0)
    ICD-10-CM Diagnosis Code C84.Z

    Other mature T/NK-cell lymphomas

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Note
    • If T-cell lineage or involvement is mentioned in conjunction with a specific lymphoma, code to the more specific description.
    Type 1 Excludes
    • angioimmunoblastic T-cell lymphoma (C86.5)
    • blastic NK-cell lymphoma (C86.4)
    • enteropathy-type T-cell lymphoma (C86.2)
    • extranodal NK-cell lymphoma, nasal type (C86.0)
    • hepatosplenic T-cell lymphoma (C86.1)
    • primary cutaneous CD30-positive T-cell proliferations (C86.6)
    • subcutaneous panniculitis-like T-cell lymphoma (C86.3)
    • T-cell leukemia (C91.1-)

Diagnosis Index entries containing back-references to C91.1:
  • Leukemia, leukemic C95.9-
    ICD-10-CM Diagnosis Code C95.9-

    Leukemia, unspecified

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    • chronic lymphocytic, of B-cell type C91.1-

ICD-10-CM Codes Adjacent To C91.1
C90.22 …… in relapse
C90.3 Solitary plasmacytoma
C90.30 …… not having achieved remission
C90.31 …… in remission
C90.32 …… in relapse
C91 Lymphoid leukemia
C91.0 Acute lymphoblastic leukemia [ALL]
C91.00 Acute lymphoblastic leukemia not having achieved remission
C91.01 Acute lymphoblastic leukemia, in remission
C91.02 Acute lymphoblastic leukemia, in relapse
C91.1 Chronic lymphocytic leukemia of B-cell type
C91.10 …… not having achieved remission
C91.11 …… in remission
C91.12 …… in relapse
C91.3 Prolymphocytic leukemia of B-cell type
C91.30 …… not having achieved remission
C91.31 …… in remission
C91.32 …… in relapse
C91.4 Hairy cell leukemia
C91.40 …… not having achieved remission
C91.41 …… in remission

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.