2021 ICD-10-CM Diagnosis Code C92.6

Acute myeloid leukemia with 11q23-abnormality

    2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
  • C92.6 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2021 edition of ICD-10-CM C92.6 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of C92.6 - other international versions of ICD-10 C92.6 may differ.
Applicable To
  • Acute myeloid leukemia with variation of MLL-gene
The following code(s) above C92.6 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C92.6:
  • C00-D49
    2021 ICD-10-CM Range C00-D49


    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
  • C81-C96
    2021 ICD-10-CM Range C81-C96

    Malignant neoplasms of lymphoid, hematopoietic and related tissue

    Type 2 Excludes
    • Kaposi's sarcoma of lymph nodes (C46.3)
    • secondary and unspecified neoplasm of lymph nodes (C77.-)
    • secondary neoplasm of bone marrow (C79.52)
    • secondary neoplasm of spleen (C78.89)
    Malignant neoplasms of lymphoid, hematopoietic and related tissue
  • C92
    ICD-10-CM Diagnosis Code C92

    Myeloid leukemia

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    • granulocytic leukemia
    • myelogenous leukemia
    Type 1 Excludes
    • personal history of leukemia (Z85.6)
    Myeloid leukemia
Clinical Information
  • An acute myeloid leukemia associated with t(9;11)(p22;q23) and mllt3 (af9)-mll fusion protein expression. Morphologically it usually has monocytic features. It may present at any age but it is more commonly seen in children. Patients may present with disseminated intravascular coagulation.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to C92.6:
  • Code Also: D47.02
    ICD-10-CM Diagnosis Code D47.02

    Systemic mastocytosis

      2018 - New Code 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Indolent systemic mastocytosis
    • Isolated bone marrow mastocytosis
    • Smoldering systemic mastocytosis
    • Systemic mastocytosis, with an associated hematological non-mast cell lineage disease (SM-AHNMD)
    Code Also
    • , if applicable, any associated hematological non-mast cell lineage disease, such as:
    • acute myeloid leukemia (C92.6-, C92.A-)
    • chronic myelomonocytic leukemia (C93.1-)
    • essential thrombocytosis (D47.3)
    • hypereosinophilic syndrome (D72.1)
    • myelodysplastic syndrome (D46.9)
    • myeloproliferative syndrome (D47.1)
    • non-Hodgkin lymphoma (C82-C85)
    • plasma cell myeloma (C90.0-)
    • polycythemia vera (D45)
    Type 1 Excludes
    • aggressive systemic mastocytosis (C96.21)
    • mast cell leukemia (C94.3-)

Diagnosis Index entries containing back-references to C92.6:
  • Leukemia, leukemic C95.9-
    ICD-10-CM Diagnosis Code C95.9-

    Leukemia, unspecified

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    • acute myeloid, NOS C92.0-
      ICD-10-CM Diagnosis Code C92.0-

      Acute myeloblastic leukemia

        2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
      Applicable To
      • Acute myeloblastic leukemia, minimal differentiation
      • Acute myeloblastic leukemia (with maturation)
      • Acute myeloblastic leukemia 1/ETO
      • Acute myeloblastic leukemia M0
      • Acute myeloblastic leukemia M1
      • Acute myeloblastic leukemia M2
      • Acute myeloblastic leukemia with t(8;21)
      • Acute myeloblastic leukemia (without a FAB classification) NOS
      • Refractory anemia with excess blasts in transformation [RAEB T]
      Type 1 Excludes
      • acute exacerbation of chronic myeloid leukemia (C92.10)
      • refractory anemia with excess of blasts not in transformation (D46.2-)
      • with
        • 11q23-abnormality C92.6-
        • variation of MLL-gene C92.6-

ICD-10-CM Codes Adjacent To C92.6
C92.31 …… in remission
C92.32 …… in relapse
C92.4 Acute promyelocytic leukemia
C92.40 …… not having achieved remission
C92.41 …… in remission
C92.42 …… in relapse
C92.5 Acute myelomonocytic leukemia
C92.50 …… not having achieved remission
C92.51 …… in remission
C92.52 …… in relapse
C92.6 Acute myeloid leukemia with 11q23-abnormality
C92.60 …… not having achieved remission
C92.61 …… in remission
C92.62 …… in relapse
C92.A Acute myeloid leukemia with multilineage dysplasia
C92.A0 …… not having achieved remission
C92.A1 …… in remission
C92.A2 …… in relapse
C92.Z Other myeloid leukemia
C92.Z0 …… not having achieved remission
C92.Z1 …… in remission

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.