2020 ICD-10-CM Diagnosis Code D46.2

Refractory anemia with excess of blasts [RAEB]

    2016 2017 - Revised Code 2018 2019 2020 Non-Billable/Non-Specific Code
  • D46.2 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2020 edition of ICD-10-CM D46.2 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D46.2 - other international versions of ICD-10 D46.2 may differ.
The following code(s) above D46.2 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D46.2:
  • C00-D49
    2020 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • D37-D48
    2020 ICD-10-CM Range D37-D48

    Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes

    Note
    • Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made.
    Type 1 Excludes
    • neoplasms of unspecified behavior (D49.-)
    Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
  • D46
    ICD-10-CM Diagnosis Code D46

    Myelodysplastic syndromes

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 2 Excludes
    • drug-induced aplastic anemia (D61.1)
    Use Additional
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
    Myelodysplastic syndromes
Clinical Information
  • A myelodysplastic syndrome characterized by the presence of 5-19% myeloblasts in the bone marrow or 2-19% blasts in the peripheral blood. It includes two categories: raeb-1and raeb-2. Cases with significant bone marrow reticulin fibrosis are called raeb with fibrosis.
  • Chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): Revised code
    • New description: Refractory anemia with excess of blasts [RAEB]
    • 2016 description: Refractory anemia with excess of blasts
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to D46.2:
  • Type 1 Excludes: C92.0
    ICD-10-CM Diagnosis Code C92.0

    Acute myeloblastic leukemia

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Acute myeloblastic leukemia, minimal differentiation
    • Acute myeloblastic leukemia (with maturation)
    • Acute myeloblastic leukemia 1/ETO
    • Acute myeloblastic leukemia M0
    • Acute myeloblastic leukemia M1
    • Acute myeloblastic leukemia M2
    • Acute myeloblastic leukemia with t(8;21)
    • Acute myeloblastic leukemia (without a FAB classification) NOS
    • Refractory anemia with excess blasts in transformation [RAEB T]
    Type 1 Excludes
    • acute exacerbation of chronic myeloid leukemia (C92.10)
    • refractory anemia with excess of blasts not in transformation (D46.2-)

Diagnosis Index entries containing back-references to D46.2:
  • RAEB D46.2- (refractory anemia with excess blasts)

ICD-10-CM Codes Adjacent To D46.2
D44.3 Neoplasm of uncertain behavior of pituitary gland
D44.4 Neoplasm of uncertain behavior of craniopharyngeal duct
D44.5 Neoplasm of uncertain behavior of pineal gland
D44.6 Neoplasm of uncertain behavior of carotid body
D44.7 Neoplasm of uncertain behavior of aortic body and other paraganglia
D44.9 Neoplasm of uncertain behavior of unspecified endocrine gland
D45 Polycythemia vera
D46 Myelodysplastic syndromes
D46.0 Refractory anemia without ring sideroblasts, so stated
D46.1 Refractory anemia with ring sideroblasts
D46.2 Refractory anemia with excess of blasts [RAEB]
D46.20 Refractory anemia with excess of blasts, unspecified
D46.21 Refractory anemia with excess of blasts 1
D46.22 Refractory anemia with excess of blasts 2
D46.A Refractory cytopenia with multilineage dysplasia
D46.B Refractory cytopenia with multilineage dysplasia and ring sideroblasts
D46.C Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality
D46.4 Refractory anemia, unspecified
D46.Z Other myelodysplastic syndromes
D46.9 Myelodysplastic syndrome, unspecified
D47 Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.