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ICD-10-CM Codes
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C00-D49
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D37-D48
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D46-
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2023 ICD-10-CM Diagnosis Code D46.C
2023 ICD-10-CM Diagnosis Code D46.C
Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- D46.C is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- Short description: Myelodysplastic syndrome w isolated del(5q) chromsoml abnlt
- The 2023 edition of ICD-10-CM D46.C became effective on October 1, 2022.
- This is the American ICD-10-CM version of D46.C - other international versions of ICD-10 D46.C may differ.
Applicable To- Myelodysplastic syndrome with 5q deletion
- 5q minus syndrome NOS
The following code(s) above
D46.C contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
D46.C:
- C00-D49
2023 ICD-10-CM Range C00-D49
NeoplasmsNote- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
- D37-D48
2023 ICD-10-CM Range D37-D48
Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromesNote- Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made.
Type 1 Excludes- neoplasms of unspecified behavior (D49.-)
- D46
ICD-10-CM Diagnosis Code D46
Myelodysplastic syndromes
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Type 2 Excludes- drug-induced aplastic anemia (D61.1)
Use Additional- code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
- Myelodysplastic syndrome with 5q deletion
- Myelodysplastic syndrome with isolated del(5q)
Clinical Information
- A myelodysplastic syndrome characterized by a deletion between bands q31 and 33 on chromosome 5. The number of blasts in the bone marrow and blood is <5%. The bone marrow is usually hypercellular or normocellular with increased number of often hypolobated megakaryocytes. The peripheral blood shows macrocytic anemia. This syndrome occurs predominantly but not exclusively in middle age to older women. The prognosis is good and transformation to acute leukemia is rare. (who, 2001)
- A rare disorder caused by loss of part of the long arm (q arm) of human chromosome 5. This syndrome affects myeloid (bone marrow) cells, causing treatment-resistant anemia, and myelodysplastic syndromes that may lead to acute myelogenous leukemia.
ICD-10-CM D46.C is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
- 811 Red blood cell disorders with mcc
- 812 Red blood cell disorders without mcc
Convert D46.C to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
- Myelodysplastic syndrome D46.9 - see also Syndrome, myelodysplastic
ICD-10-CM Diagnosis Code D46.9
Myelodysplastic syndrome, unspecified
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- with
- 5q deletion D46.C
- isolated del D46.C (5q)
- Syndrome - see also Disease
- myelodysplastic D46.9
ICD-10-CM Diagnosis Code D46.9
Myelodysplastic syndrome, unspecified
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- with
- 5q deletion D46.C
- isolated del D46.C (5q)
- 5q minus NOS D46.C
ICD-10-CM Codes Adjacent To D46.C
D46 Myelodysplastic syndromes
D46.0 Refractory anemia without ring sideroblasts, so stated
D46.1 Refractory anemia with ring sideroblasts
D46.2 Refractory anemia with excess of blasts [RAEB]
D46.20 Refractory anemia with excess of blasts, unspecified
D46.21 Refractory anemia with excess of blasts 1
D46.22 Refractory anemia with excess of blasts 2
D46.A Refractory cytopenia with multilineage dysplasia
D46.B Refractory cytopenia with multilineage dysplasia and ring sideroblasts
D46.C
Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality
D46.4 Refractory anemia, unspecified
D46.Z Other myelodysplastic syndromes
D46.9 Myelodysplastic syndrome, unspecified
D47 Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
D47.0 Mast cell neoplasms of uncertain behavior
D47.09 Other mast cell neoplasms of uncertain behavior
D47.1 Chronic myeloproliferative disease
D47.2 Monoclonal gammopathy
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
