2021 ICD-10-CM Diagnosis Code D47.2

Monoclonal gammopathy

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • D47.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM D47.2 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D47.2 - other international versions of ICD-10 D47.2 may differ.
Applicable To
  • Monoclonal gammopathy of undetermined significance [MGUS]
The following code(s) above D47.2 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D47.2:
  • C00-D49
    2021 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • D37-D48
    2021 ICD-10-CM Range D37-D48

    Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes

    Note
    • Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made.
    Type 1 Excludes
    • neoplasms of unspecified behavior (D49.-)
    Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
Approximate Synonyms
  • Benign monoclonal gammopathy
  • Hypogammaglobulinemia co-occurrent and due to monoclonal gammopathy of undetermined significance
  • Monoclonal gammopathy (clinical)
  • Monoclonal gammopathy of uncertain significance
  • Monoclonal gammopathy of undetermined significance w hypogammaglobulinemia
  • Monoclonal gammopathy, benign
  • Monoclonal gammopathy, undetermined significance
  • Monoclonal paraproteinemia
Clinical Information
  • A benign condition in which there is a higher-than-normal level of a protein called m protein in the blood. Patients with mgus are at an increased risk of developing cancer.
  • A laboratory test result indicating the presence of an abnormally high level of monoclonal immunoglobulins in the blood or urine.
  • A plasma cell disorder in which an abnormal amount of a single immunoglobulin is present in the serum. Up to 25% of cases of monoclonal gammopathy of undetermined significance (mgus) progress to a b-cell malignancy or myeloma. Mgus may occur in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases.
  • Conditions characterized by the presence of m protein (monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.
ICD-10-CM D47.2 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 814 Reticuloendothelial and immunity disorders with mcc
  • 815 Reticuloendothelial and immunity disorders with cc
  • 816 Reticuloendothelial and immunity disorders without cc/mcc

Convert D47.2 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to D47.2:
  • Type 1 Excludes: D89
    , E88.0
    ICD-10-CM Diagnosis Code D89

    Other disorders involving the immune mechanism, not elsewhere classified

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • hyperglobulinemia NOS (R77.1)
    • monoclonal gammopathy (of undetermined significance) (D47.2)
    Type 2 Excludes
    • transplant failure and rejection (T86.-)
    ICD-10-CM Diagnosis Code E88.0

    Disorders of plasma-protein metabolism, not elsewhere classified

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • monoclonal gammopathy (of undetermined significance) (D47.2)
    • polyclonal hypergammaglobulinemia (D89.0)
    • Waldenström macroglobulinemia (C88.0)
    Type 2 Excludes
    • disorder of lipoprotein metabolism (E78.-)

Diagnosis Index entries containing back-references to D47.2:
  • Gammopathy (of undetermined significance [MGUS]) D47.2
    • associated with lymphoplasmacytic dyscrasia D47.2
    • monoclonal D47.2
  • Macroglobulinemia (idiopathic) (primary) C88.0
    ICD-10-CM Diagnosis Code C88.0

    Waldenström macroglobulinemia

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Lymphoplasmacytic lymphoma with IgM-production
    • Macroglobulinemia (idiopathic) (primary)
    Type 1 Excludes
    • small cell B-cell lymphoma (C83.0)
    • monoclonal D47.2 (essential)
  • Paraproteinemia D89.2
    ICD-10-CM Diagnosis Code D89.2

    Hypergammaglobulinemia, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    • monoclonal D47.2
    • secondary to malignant disease D47.2
  • Syndrome - see also Disease
    • Schnitzler D47.2

ICD-10-CM Codes Adjacent To D47.2
D46.C Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality
D46.4 Refractory anemia, unspecified
D46.Z Other myelodysplastic syndromes
D46.9 Myelodysplastic syndrome, unspecified
D47 Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
D47.0 Mast cell neoplasms of uncertain behavior
D47.01 Cutaneous mastocytosis
D47.02 Systemic mastocytosis
D47.09 Other mast cell neoplasms of uncertain behavior
D47.1 Chronic myeloproliferative disease
D47.2 Monoclonal gammopathy
D47.3 Essential (hemorrhagic) thrombocythemia
D47.4 Osteomyelofibrosis
D47.Z Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
D47.Z1 Post-transplant lymphoproliferative disorder (PTLD)
D47.Z2 Castleman disease
D47.Z9 Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
D47.9 Neoplasm of uncertain behavior of lymphoid, hematopoietic and related tissue, unspecified
D48 Neoplasm of uncertain behavior of other and unspecified sites
D48.0 Neoplasm of uncertain behavior of bone and articular cartilage
D48.1 Neoplasm of uncertain behavior of connective and other soft tissue

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.