2022 ICD-10-CM Diagnosis Code D48.1

Neoplasm of uncertain behavior of connective and other soft tissue

    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  • D48.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • Short description: Neoplasm of uncertain behavior of connctv/soft tiss
  • The 2022 edition of ICD-10-CM D48.1 became effective on October 1, 2021.
  • This is the American ICD-10-CM version of D48.1 - other international versions of ICD-10 D48.1 may differ.
Applicable To
  • Neoplasm of uncertain behavior of connective tissue of ear
  • Neoplasm of uncertain behavior of connective tissue of eyelid
  • Stromal tumors of uncertain behavior of digestive system
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D48.1. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • neoplasm of uncertain behavior of articular cartilage (
    ICD-10-CM Diagnosis Code D48.0

    Neoplasm of uncertain behavior of bone and articular cartilage

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Type 1 Excludes
    • neoplasm of uncertain behavior of cartilage of ear (D48.1)
    • neoplasm of uncertain behavior of cartilage of larynx (D38.0)
    • neoplasm of uncertain behavior of cartilage of nose (D38.5)
    • neoplasm of uncertain behavior of connective tissue of eyelid (D48.1)
    • neoplasm of uncertain behavior of synovia (D48.1)
    D48.0
    )
  • neoplasm of uncertain behavior of cartilage of larynx (
    ICD-10-CM Diagnosis Code D38.0

    Neoplasm of uncertain behavior of larynx

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Neoplasm of uncertain behavior of aryepiglottic fold or interarytenoid fold, laryngeal aspect
    • Neoplasm of uncertain behavior of epiglottis (suprahyoid portion)
    Type 1 Excludes
    • neoplasm of uncertain behavior of aryepiglottic fold or interarytenoid fold NOS (D37.05)
    • neoplasm of uncertain behavior of hypopharyngeal aspect of aryepiglottic fold (D37.05)
    • neoplasm of uncertain behavior of marginal zone of aryepiglottic fold (D37.05)
    D38.0
    )
  • neoplasm of uncertain behavior of cartilage of nose (
    ICD-10-CM Diagnosis Code D38.5

    Neoplasm of uncertain behavior of other respiratory organs

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Neoplasm of uncertain behavior of accessory sinuses
    • Neoplasm of uncertain behavior of cartilage of nose
    • Neoplasm of uncertain behavior of middle ear
    • Neoplasm of uncertain behavior of nasal cavities
    Type 1 Excludes
    • neoplasm of uncertain behavior of ear (external) (skin) (D48.5)
    • neoplasm of uncertain behavior of nose NOS (D48.7)
    • neoplasm of uncertain behavior of skin of nose (D48.5)
    D38.5
    )
  • neoplasm of uncertain behavior of connective tissue of breast (
    ICD-10-CM Diagnosis Code D48.6

    Neoplasm of uncertain behavior of breast

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Applicable To
    • Neoplasm of uncertain behavior of connective tissue of breast
    • Cystosarcoma phyllodes
    Type 1 Excludes
    • neoplasm of uncertain behavior of skin of breast (D48.5)
    D48.6-
    )
The following code(s) above D48.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D48.1:
  • C00-D49
    2022 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
  • D37-D48
    2022 ICD-10-CM Range D37-D48

    Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes

    Note
    • Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made.
    Type 1 Excludes
    • neoplasms of unspecified behavior (D49.-)
    Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
  • D48
    ICD-10-CM Diagnosis Code D48

    Neoplasm of uncertain behavior of other and unspecified sites

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • neurofibromatosis (nonmalignant) (Q85.0-)
    Neoplasm of uncertain behavior of other and unspecified sites
Approximate Synonyms
  • Atypical fibrous histiocytoma of soft tissue
  • Atypical fibroxanthoma of skin
  • Atypical fibroxanthoma of skin of neck
  • Atypical fibroxanthoma of skin of scalp
  • Atypical fibroxanthoma, skin
  • Atypical lipoma of soft tissue
  • Cancer uncert behavior gastrointestinal sft tissue
  • Desmoid tumor
  • Desmoplastic fibroma of lower limb
  • Desmoplastic fibroma of upper limb
  • Desmoplastic fibroma, lower limb
  • Desmoplastic fibroma, upper limb
  • Fibroxanthoma of neck, atypical
  • Fibroxanthoma of scalp, atypical
  • Gastrointestinal stromal tumor
  • Giant cell tumor of tendon sheath
  • Hemangiopericytoma
  • Histiocytoma of soft tissue, fibrous, atypical
  • Lipoma of soft tissue, atypical
  • Lymphangiomyomatosis
  • Lymphangiomyomatosis of connective tissue
  • Neoplasm of uncertain behavior hand, soft tissue
  • Neoplasm of uncertain behavior nerve of hand
  • Neoplasm of uncertain behavior of hand nerve
  • Neoplasm of uncertain behavior of soft tissue
  • Neoplasm of uncertain behavior of soft tissue of hand
  • Neoplasm of uncertain behavior of soft tissues
  • Neoplasm of uncertain behavior of soft tissues of gastrointestinal tract
  • Neoplasm of uncertain behavior of soft tissues of pelvis
  • Neoplasm of uncertain behavior pelvis, soft tissue
  • Neoplasm of uncertain behavior, desmoid tumor
  • Neoplasm unspecif nature gastrointestinal stroma
  • Nodular tenosynovitis
  • Pulmonary lymphangioleiomyomatosis
  • Synovial chondromatosis of elbow
  • Synovial chondromatosis of hip
  • Synovial chondromatosis of knee
  • Synovial chondromatosis of temporomandibular joint
  • Synovial chondromatosis of wrist
  • Synovial chondromatosis, elbow
  • Synovial chondromatosis, hip
  • Synovial chondromatosis, knee
  • Synovial chondromatosis, wrist
ICD-10-CM D48.1 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):
  • 564 Other musculoskeletal system and connective tissue diagnoses with mcc
  • 565 Other musculoskeletal system and connective tissue diagnoses with cc
  • 566 Other musculoskeletal system and connective tissue diagnoses without cc/mcc

Convert D48.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
Code annotations containing back-references to D48.1:
  • Code First: M63
    ICD-10-CM Diagnosis Code M63

    Disorders of muscle in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Code First
    Type 1 Excludes
    • myopathy in cysticercosis (B69.81)
    • myopathy in endocrine diseases (G73.7)
    • myopathy in metabolic diseases (G73.7)
    • myopathy in sarcoidosis (D86.87)
    • myopathy in secondary syphilis (A51.49)
    • myopathy in syphilis (late) (A52.78)
    • myopathy in toxoplasmosis (B58.82)
    • myopathy in tuberculosis (A18.09)
  • Type 1 Excludes: D37
    , D48.0
    , D48.0
    , D48.0
    , D48.7
    ICD-10-CM Diagnosis Code D37

    Neoplasm of uncertain behavior of oral cavity and digestive organs

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • stromal tumors of uncertain behavior of digestive system (D48.1)
    ICD-10-CM Diagnosis Code D48.0

    Neoplasm of uncertain behavior of bone and articular cartilage

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Type 1 Excludes
    • neoplasm of uncertain behavior of cartilage of ear (D48.1)
    • neoplasm of uncertain behavior of cartilage of larynx (D38.0)
    • neoplasm of uncertain behavior of cartilage of nose (D38.5)
    • neoplasm of uncertain behavior of connective tissue of eyelid (D48.1)
    • neoplasm of uncertain behavior of synovia (D48.1)
    ICD-10-CM Diagnosis Code D48.0

    Neoplasm of uncertain behavior of bone and articular cartilage

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Type 1 Excludes
    • neoplasm of uncertain behavior of cartilage of ear (D48.1)
    • neoplasm of uncertain behavior of cartilage of larynx (D38.0)
    • neoplasm of uncertain behavior of cartilage of nose (D38.5)
    • neoplasm of uncertain behavior of connective tissue of eyelid (D48.1)
    • neoplasm of uncertain behavior of synovia (D48.1)
    ICD-10-CM Diagnosis Code D48.0

    Neoplasm of uncertain behavior of bone and articular cartilage

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Type 1 Excludes
    • neoplasm of uncertain behavior of cartilage of ear (D48.1)
    • neoplasm of uncertain behavior of cartilage of larynx (D38.0)
    • neoplasm of uncertain behavior of cartilage of nose (D38.5)
    • neoplasm of uncertain behavior of connective tissue of eyelid (D48.1)
    • neoplasm of uncertain behavior of synovia (D48.1)
    ICD-10-CM Diagnosis Code D48.7

    Neoplasm of uncertain behavior of other specified sites

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Neoplasm of uncertain behavior of eye
    • Neoplasm of uncertain behavior of heart
    • Neoplasm of uncertain behavior of peripheral nerves of orbit
    Type 1 Excludes
    • neoplasm of uncertain behavior of connective tissue (D48.1)
    • neoplasm of uncertain behavior of skin of eyelid (D48.5)

Diagnosis Index entries containing back-references to D48.1:

ICD-10-CM Codes Adjacent To D48.1
D47.2 Monoclonal gammopathy
D47.3 Essential (hemorrhagic) thrombocythemia
D47.4 Osteomyelofibrosis
D47.Z Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
D47.Z1 Post-transplant lymphoproliferative disorder (PTLD)
D47.Z2 Castleman disease
D47.Z9 Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
D47.9 Neoplasm of uncertain behavior of lymphoid, hematopoietic and related tissue, unspecified
D48 Neoplasm of uncertain behavior of other and unspecified sites
D48.0 Neoplasm of uncertain behavior of bone and articular cartilage
D48.1 Neoplasm of uncertain behavior of connective and other soft tissue
D48.2 Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system
D48.3 Neoplasm of uncertain behavior of retroperitoneum
D48.4 Neoplasm of uncertain behavior of peritoneum
D48.5 Neoplasm of uncertain behavior of skin
D48.6 Neoplasm of uncertain behavior of breast
D48.60 Neoplasm of uncertain behavior of unspecified breast
D48.61 Neoplasm of uncertain behavior of right breast
D48.62 Neoplasm of uncertain behavior of left breast
D48.7 Neoplasm of uncertain behavior of other specified sites
D48.9 Neoplasm of uncertain behavior, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.