2022 ICD-10-CM Diagnosis Code D49

Neoplasms of unspecified behavior

    2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
  • D49 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2022 edition of ICD-10-CM D49 became effective on October 1, 2021.
  • This is the American ICD-10-CM version of D49 - other international versions of ICD-10 D49 may differ.
Note
  • Category
    ICD-10-CM Diagnosis Code D49

    Neoplasms of unspecified behavior

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Includes
    • 'growth' NOS
    • neoplasm NOS
    • new growth NOS
    • tumor NOS
    Note
    • Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
    Type 1 Excludes
    • neoplasms of uncertain behavior (D37-D44, D48)
    D49
    classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D49. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • neoplasms of uncertain behavior (
    ICD-10-CM Diagnosis Code D37

    Neoplasm of uncertain behavior of oral cavity and digestive organs

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • stromal tumors of uncertain behavior of digestive system (D48.1)
    D37
    -
    ICD-10-CM Diagnosis Code D44

    Neoplasm of uncertain behavior of endocrine glands

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • multiple endocrine adenomatosis (E31.2-)
    • multiple endocrine neoplasia (E31.2-)
    • neoplasm of uncertain behavior of endocrine pancreas (D37.8)
    • neoplasm of uncertain behavior of ovary (D39.1-)
    • neoplasm of uncertain behavior of testis (D40.1-)
    • neoplasm of uncertain behavior of thymus (D38.4)
    D44
    ,
    ICD-10-CM Diagnosis Code D48

    Neoplasm of uncertain behavior of other and unspecified sites

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • neurofibromatosis (nonmalignant) (Q85.0-)
    D48
    )
Includes
Includes Help
"Includes" further defines, or give examples of, the content of the code or category.
  • 'growth' NOS
  • neoplasm NOS
  • new growth NOS
  • tumor NOS
The following code(s) above D49 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D49:
  • C00-D49
    2022 ICD-10-CM Range C00-D49

    Neoplasms

    Note
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms
Clinical Information
  • A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias.
  • A general term for autonomous tissue growth in which the malignancy status has not been established and for which the transformed cell type has not been specifically identified.
  • An abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Neoplasms may be benign (not cancer), or malignant (cancer).
  • An abnormal tissue growth resulted from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant ones exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias.
  • Gradual increase in the number, the size, and the complexity of cells of an individual. Growth generally results in increase in organ weight; body weight; and body height.
  • Growth of the tumor after morphology of cell has changed; cells may or may not have transformed to a cancerous state.
  • Increases in physical dimensions or maturity of organ systems
  • New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
  • Normal increase in bone size and body weight during growth years
  • Processes that promote either specific or nonspecific formation of additional tissue mass, typically by cell proliferation.
  • The increase in size or mass of an entire organism, a part of an organism or a cell. [goc:bf, goc:ma]
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
Code annotations containing back-references to D49:
  • Note: D49
    ICD-10-CM Diagnosis Code D49

    Neoplasms of unspecified behavior

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Includes
    • 'growth' NOS
    • neoplasm NOS
    • new growth NOS
    • tumor NOS
    Note
    • Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
    Type 1 Excludes
    • neoplasms of uncertain behavior (D37-D44, D48)
ICD-10-CM Codes Adjacent To D49
D48.2 Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system
D48.3 Neoplasm of uncertain behavior of retroperitoneum
D48.4 Neoplasm of uncertain behavior of peritoneum
D48.5 Neoplasm of uncertain behavior of skin
D48.6 Neoplasm of uncertain behavior of breast
D48.60 Neoplasm of uncertain behavior of unspecified breast
D48.61 Neoplasm of uncertain behavior of right breast
D48.62 Neoplasm of uncertain behavior of left breast
D48.7 Neoplasm of uncertain behavior of other specified sites
D48.9 Neoplasm of uncertain behavior, unspecified
D49 Neoplasms of unspecified behavior
D49.0 Neoplasm of unspecified behavior of digestive system
D49.1 Neoplasm of unspecified behavior of respiratory system
D49.2 Neoplasm of unspecified behavior of bone, soft tissue, and skin
D49.3 Neoplasm of unspecified behavior of breast
D49.4 Neoplasm of unspecified behavior of bladder
D49.5 Neoplasm of unspecified behavior of other genitourinary organs
D49.51 Neoplasm of unspecified behavior of kidney
D49.511 Neoplasm of unspecified behavior of right kidney
D49.512 Neoplasm of unspecified behavior of left kidney
D49.519 Neoplasm of unspecified behavior of unspecified kidney

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.