2020 ICD-10-CM Diagnosis Code D51.0

Vitamin B12 deficiency anemia due to intrinsic factor deficiency

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D51.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • Short description: Vitamin B12 defic anemia due to intrinsic factor deficiency
  • The 2020 edition of ICD-10-CM D51.0 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D51.0 - other international versions of ICD-10 D51.0 may differ.
Applicable To
  • Addison anemia
  • Biermer anemia
  • Pernicious (congenital) anemia
  • Congenital intrinsic factor deficiency
The following code(s) above D51.0 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D51.0:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D51
    ICD-10-CM Diagnosis Code D51

    Vitamin B12 deficiency anemia

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • vitamin B12 deficiency (E53.8)
    Vitamin B12 deficiency anemia
Approximate Synonyms
  • Anemia, pernicious
  • Pernicious anemia
Clinical Information
  • A decrease in red blood cells that occurs when the body cannot absorb vitamin b12
  • A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin b 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)
  • A type of anemia (low red blood cell count) caused by the body's inability to absorb vitamin b12.
  • Anemia due to poor intestinal absorption of vitamin b12 caused by defective production of intrinsic factor (a carrier protein) by the gastric mucosa.
  • Megaloblastic anemia caused by vitamin b-12 deficiency due to impaired absorption. The impaired absorption of vitamin b-12 is secondary to atrophic gastritis and loss of gastric parietal cells.
ICD-10-CM D51.0 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc

Convert D51.0 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to D51.0:
  • Code First: G32.0
    ICD-10-CM Diagnosis Code G32.0

    Subacute combined degeneration of spinal cord in diseases classified elsewhere

      2016 2017 2018 2019 2020 Billable/Specific Code Manifestation Code
    Applicable To
    • Dana-Putnam syndrome
    • Sclerosis of spinal cord (combined) (dorsolateral) (posterolateral)
    Code First
    • underlying disease, such as:
    • anemia (D51.9)
    • dietary (D51.3)
    • pernicious (D51.0)
    • vitamin B12 deficiency (E53.8)
    Type 1 Excludes
    • syphilitic combined degeneration of spinal cord (A52.11)

Diagnosis Index entries containing back-references to D51.0:
  • Addison-Biermer anemia D51.0 (pernicious)
  • Addison's
    • anemia D51.0 (pernicious)
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
    ICD-10-CM Diagnosis Code D64.9

    Anemia, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • combined system disease NEC D51.0
    • congenital P61.4
      ICD-10-CM Diagnosis Code P61.4

      Other congenital anemias, not elsewhere classified

        2016 2017 2018 2019 2020 Billable/Specific Code Code on Newborn Record
      Applicable To
      • Congenital anemia NOS
      • pernicious D51.0
    • deficiency D53.9
      ICD-10-CM Diagnosis Code D53.9

      Nutritional anemia, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Simple chronic anemia
      Type 1 Excludes
      • vitamin B12 NOS D51.9
        ICD-10-CM Diagnosis Code D51.9

        Vitamin B12 deficiency anemia, unspecified

          2016 2017 2018 2019 2020 Billable/Specific Code
        • due to
          • intrinsic factor deficiency D51.0
        • pernicious D51.0
    • progressive D64.9
      ICD-10-CM Diagnosis Code D64.9

      Anemia, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • malignant D51.0
      • pernicious D51.0
    • vitamin
      • B12 deficiency D51.0 (dietary)
    • Addison D51.0 (-Biermer) (pernicious)
    • Biermer's D51.0 (pernicious)
    • cytogenic D51.0
    • malignant D51.0 (progressive)
    • pernicious D51.0 (congenital) (malignant) (progressive)
  • Biermer's D51.0 (pernicious)
  • Congenital - see also condition
    • intrinsic factor deficiency D51.0
  • Deficiency, deficient
  • Degeneration, degenerative
    • combined (spinal cord) (subacute) E53.8
      ICD-10-CM Diagnosis Code E53.8

      Deficiency of other specified B group vitamins

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Biotin deficiency
      • Cyanocobalamin deficiency
      • Folate deficiency
      • Folic acid deficiency
      • Pantothenic acid deficiency
      • Vitamin B12 deficiency
      Type 1 Excludes
      • folate deficiency anemia (D52.-)
      • vitamin B12 deficiency anemia (D51.-)
  • Disease, diseased - see also Syndrome
    • Addison's anemia D51.0 (pernicious)
    • Biermer's D51.0 (pernicious anemia)
    • Lichtheim's D51.0 (subacute combined sclerosis with pernicious anemia)
    • Putnam's D51.0 (subacute combined sclerosis with pernicious anemia)
    • Runeberg's D51.0 (progressive pernicious anemia)
  • Glossitis (chronic superficial) (gangrenous) (Moeller's) K14.0
    ICD-10-CM Diagnosis Code K14.0

    Glossitis

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Abscess of tongue
    • Ulceration (traumatic) of tongue
    Type 1 Excludes
    • atrophic glossitis (K14.4)
    • Hunter's D51.0
  • Hunter's
    • glossitis D51.0
  • Lichtheim's disease or syndrome D51.0
  • Myasthenia G70.9
    ICD-10-CM Diagnosis Code G70.9

    Myoneural disorder, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
  • Myelopathy (spinal cord) G95.9
    ICD-10-CM Diagnosis Code G95.9

    Disease of spinal cord, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Myelopathy NOS
    • in (due to)
      • pernicious anemia D51.0
  • Neuropathy, neuropathic G62.9
    ICD-10-CM Diagnosis Code G62.9

    Polyneuropathy, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Neuropathy NOS
    • vitamin B12 E53.8
      ICD-10-CM Diagnosis Code E53.8

      Deficiency of other specified B group vitamins

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Biotin deficiency
      • Cyanocobalamin deficiency
      • Folate deficiency
      • Folic acid deficiency
      • Pantothenic acid deficiency
      • Vitamin B12 deficiency
      Type 1 Excludes
      • folate deficiency anemia (D52.-)
      • vitamin B12 deficiency anemia (D51.-)
  • Polyneuropathy (peripheral) G62.9
    ICD-10-CM Diagnosis Code G62.9

    Polyneuropathy, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Neuropathy NOS
    • transthyretin-related (ATTR) E85.1
      ICD-10-CM Diagnosis Code E85.1

      Neuropathic heredofamilial amyloidosis

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Amyloid polyneuropathy (Portuguese)
      • Transthyretin-related (ATTR) familial amyloid polyneuropathy
      • vitamin B12 deficiency E53.8
        ICD-10-CM Diagnosis Code E53.8

        Deficiency of other specified B group vitamins

          2016 2017 2018 2019 2020 Billable/Specific Code
        Applicable To
        • Biotin deficiency
        • Cyanocobalamin deficiency
        • Folate deficiency
        • Folic acid deficiency
        • Pantothenic acid deficiency
        • Vitamin B12 deficiency
        Type 1 Excludes
        • folate deficiency anemia (D52.-)
        • vitamin B12 deficiency anemia (D51.-)
  • Runeberg's disease D51.0
  • Syndrome - see also Disease
    • Dana-Putnam D51.0
    • hunterian glossitis D51.0
    • Lichtheim's D51.0
    • Putnam-Dana D51.0

ICD-10-CM Codes Adjacent To D51.0
D49.8 Neoplasm of unspecified behavior of other specified sites
D49.81 Neoplasm of unspecified behavior of retina and choroid
D49.89 Neoplasm of unspecified behavior of other specified sites
D49.9 Neoplasm of unspecified behavior of unspecified site
D50 Iron deficiency anemia
D50.0 Iron deficiency anemia secondary to blood loss (chronic)
D50.1 Sideropenic dysphagia
D50.8 Other iron deficiency anemias
D50.9 Iron deficiency anemia, unspecified
D51 Vitamin B12 deficiency anemia
D51.0 Vitamin B12 deficiency anemia due to intrinsic factor deficiency
D51.1 Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria
D51.2 Transcobalamin II deficiency
D51.3 Other dietary vitamin B12 deficiency anemia
D51.8 Other vitamin B12 deficiency anemias
D51.9 Vitamin B12 deficiency anemia, unspecified
D52 Folate deficiency anemia
D52.0 Dietary folate deficiency anemia
D52.1 Drug-induced folate deficiency anemia
D52.8 Other folate deficiency anemias
D52.9 Folate deficiency anemia, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.