2023

  1. ICD-10-CM Codes
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  2. D50-D89
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  3. D50-D53
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  4. D53-
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  5. 2023 ICD-10-CM Diagnosis Code D53.0

2023 ICD-10-CM Diagnosis Code D53.0

Protein deficiency anemia

    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  • D53.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2023 edition of ICD-10-CM D53.0 became effective on October 1, 2022.
  • This is the American ICD-10-CM version of D53.0 - other international versions of ICD-10 D53.0 may differ.
Applicable To
  • Amino-acid deficiency anemia
  • Orotaciduric anemia
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D53.0. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Lesch-Nyhan syndrome (
    ICD-10-CM Diagnosis Code E79.1

    Lesch-Nyhan syndrome

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Applicable To
    • HGPRT deficiency
    E79.1
    )
The following code(s) above D53.0 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D53.0:
  • D50-D89
    2023 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D53
    ICD-10-CM Diagnosis Code D53

    Other nutritional anemias

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Includes
    • megaloblastic anemia unresponsive to vitamin B12 or folate therapy
    Other nutritional anemias
Approximate Synonyms
  • Amino acid deficiency anemia
  • Anemia, amino acid deficiency
ICD-10-CM D53.0 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc

Convert D53.0 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
Code annotations containing back-references to D53.0:
  • Type 1 Excludes: E79
    ICD-10-CM Diagnosis Code E79

    Disorders of purine and pyrimidine metabolism

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Type 1 Excludes

Diagnosis Index entries containing back-references to D53.0:
  • Aciduria
    • orotic (congenital) (hereditary) (pyrimidine deficiency) E79.8
      ICD-10-CM Diagnosis Code E79.8

      Other disorders of purine and pyrimidine metabolism

        2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
      Applicable To
      • Hereditary xanthinuria
      • anemia D53.0
  • Amino-acid disorder E72.9
    ICD-10-CM Diagnosis Code E72.9

    Disorder of amino-acid metabolism, unspecified

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    • anemia D53.0
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
    ICD-10-CM Diagnosis Code D64.9

    Anemia, unspecified

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    • deficiency D53.9
      ICD-10-CM Diagnosis Code D53.9

      Nutritional anemia, unspecified

        2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
      Applicable To
      • Simple chronic anemia
      Type 1 Excludes
      • amino-acid D53.0
      • protein D53.0
    • due to (in) (with)
    • megaloblastic D53.1
      ICD-10-CM Diagnosis Code D53.1

      Other megaloblastic anemias, not elsewhere classified

        2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
      Applicable To
      • Megaloblastic anemia NOS
      Type 1 Excludes
      • Di Guglielmo's disease (C94.0)
      • orotic aciduria D53.0
    • amino-acid-deficiency D53.0
    • orotaciduric D53.0 (congenital) (hereditary)
    • protein-deficiency D53.0
  • Deficiency, deficient
    • protein E46
      - see also Malnutrition
      ICD-10-CM Diagnosis Code E46

      Unspecified protein-calorie malnutrition

        2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
      Applicable To
      • Malnutrition NOS
      • Protein-calorie imbalance NOS
      Type 1 Excludes
      • nutritional deficiency NOS (E63.9)
      • anemia D53.0
  • Orotaciduria, oroticaciduria (congenital) (hereditary) (pyrimidine deficiency) E79.8
    ICD-10-CM Diagnosis Code E79.8

    Other disorders of purine and pyrimidine metabolism

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Applicable To
    • Hereditary xanthinuria
    • anemia D53.0

ICD-10-CM Codes Adjacent To D53.0
D51.2 Transcobalamin II deficiency
D51.3 Other dietary vitamin B12 deficiency anemia
D51.8 Other vitamin B12 deficiency anemias
D51.9 Vitamin B12 deficiency anemia, unspecified
D52 Folate deficiency anemia
D52.0 Dietary folate deficiency anemia
D52.1 Drug-induced folate deficiency anemia
D52.8 Other folate deficiency anemias
D52.9 Folate deficiency anemia, unspecified
D53 Other nutritional anemias
D53.0 Protein deficiency anemia
D53.1 Other megaloblastic anemias, not elsewhere classified
D53.2 Scorbutic anemia
D53.8 Other specified nutritional anemias
D53.9 Nutritional anemia, unspecified
D55 Anemia due to enzyme disorders
D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
D55.1 Anemia due to other disorders of glutathione metabolism
D55.2 Anemia due to disorders of glycolytic enzymes
D55.21 Anemia due to pyruvate kinase deficiency
D55.29 Anemia due to other disorders of glycolytic enzymes

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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