2020 ICD-10-CM Diagnosis Code D53.1

Other megaloblastic anemias, not elsewhere classified

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D53.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D53.1 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D53.1 - other international versions of ICD-10 D53.1 may differ.
Applicable To
  • Megaloblastic anemia NOS
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D53.1. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Di Guglielmo's disease (
    ICD-10-CM Diagnosis Code C94.0

    Acute erythroid leukemia

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Acute myeloid leukemia M6(a)(b)
    • Erythroleukemia
    C94.0
    )
The following code(s) above D53.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D53.1:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D53
    ICD-10-CM Diagnosis Code D53

    Other nutritional anemias

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Includes
    • megaloblastic anemia unresponsive to vitamin B12 or folate therapy
    Other nutritional anemias
Approximate Synonyms
  • Acute megaloblastic anemia
  • Anemia, b12 and folate deficiency
  • Anemia, megaloblastic
  • Anemia, megaloblastic, acute
  • Anemia, megaloblastic, refractory
  • Combined b12 and folate deficiency anemia
  • Megaloblastic anemia
  • Primary malignant neoplasm of renal pelvis
  • Refractory megaloblastic anemia
Clinical Information
  • A disorder characterized by the presence of anemia, abnormally large red blood cells (megalocytes or macrocytes), and megaloblasts.
  • Anemia characterized by the presence of unusually large erythroblasts in the bone marrow called megaloblasts. It is usually caused by vitamin b12 or folic acid deficiency. Other causes include toxins and drugs.
  • Anemias associated with impaired dna synthesis in bone marrow progenitor cells leading to odd shaped, macrocytic, or dysfunctional erythrocytes; usually caused by b12 or folate deficiency.
ICD-10-CM D53.1 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc

Convert D53.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to D53.1:
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
    ICD-10-CM Diagnosis Code D64.9

    Anemia, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • deficiency D53.9
      ICD-10-CM Diagnosis Code D53.9

      Nutritional anemia, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Simple chronic anemia
      Type 1 Excludes
      • combined B12 and folate D53.1
    • megaloblastic D53.1
      • combined B12 and folate deficiency D53.1
      • refractory D53.1
      • specified type NEC D53.1
    • refractory D46.4
      ICD-10-CM Diagnosis Code D46.4

      Refractory anemia, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • megaloblastic D53.1
    • achrestic D53.1
    • dimorphic D53.1
    • diphasic D53.1
    • megalocytic D53.1
  • Megalocytic anemia D53.1

ICD-10-CM Codes Adjacent To D53.1
D51.3 Other dietary vitamin B12 deficiency anemia
D51.8 Other vitamin B12 deficiency anemias
D51.9 Vitamin B12 deficiency anemia, unspecified
D52 Folate deficiency anemia
D52.0 Dietary folate deficiency anemia
D52.1 Drug-induced folate deficiency anemia
D52.8 Other folate deficiency anemias
D52.9 Folate deficiency anemia, unspecified
D53 Other nutritional anemias
D53.0 Protein deficiency anemia
D53.1 Other megaloblastic anemias, not elsewhere classified
D53.2 Scorbutic anemia
D53.8 Other specified nutritional anemias
D53.9 Nutritional anemia, unspecified
D55 Anemia due to enzyme disorders
D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
D55.1 Anemia due to other disorders of glutathione metabolism
D55.2 Anemia due to disorders of glycolytic enzymes
D55.3 Anemia due to disorders of nucleotide metabolism
D55.8 Other anemias due to enzyme disorders
D55.9 Anemia due to enzyme disorder, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.