ICD-10-CM Codes
D50-D89
D55-D59
D56-
2023 ICD-10-CM Diagnosis Code D56.3

2023 ICD-10-CM Diagnosis Code D56.3

Thalassemia minor

2016

2017

2018

2019

2020

2021

2022

2023

Billable/Specific Code

D56.3 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2023 edition of ICD-10-CM D56.3 became effective on October 1, 2022.
This is the American ICD-10-CM version of D56.3 - other international versions of ICD-10 D56.3 may differ.

Applicable To

Alpha thalassemia minor
Alpha thalassemia silent carrier
Alpha thalassemia trait
Beta thalassemia minor
Beta thalassemia trait
Delta-beta thalassemia minor
Delta-beta thalassemia trait
Thalassemia trait NOS

Type 1 Excludes

Type 1 Excludes Help

A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D56.3. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

alpha thalassemia (
ICD-10-CM Diagnosis Code D56.0
Alpha thalassemia
Applicable To
- Alpha thalassemia major
- Hemoglobin H Constant Spring
- Hemoglobin H disease
- Hydrops fetalis due to alpha thalassemia
- Severe alpha thalassemia
- Triple gene defect alpha thalassemia
Type 1 Excludes
- alpha thalassemia trait or minor (D56.3)
- asymptomatic alpha thalassemia (D56.3)
- hydrops fetalis due to isoimmunization (P56.0)
- hydrops fetalis not due to immune hemolysis (P83.2)
Use Additional
- code, if applicable, for hydrops fetalis due to alpha thalassemia (P56.99)
D56.0
)
beta thalassemia (
ICD-10-CM Diagnosis Code D56.1
Beta thalassemia
Applicable To
- Beta thalassemia major
- Cooley's anemia
- Homozygous beta thalassemia
- Severe beta thalassemia
- Thalassemia intermedia
- Thalassemia major
Type 1 Excludes
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell beta thalassemia (D57.4-)
D56.1
)
delta-beta thalassemia (
ICD-10-CM Diagnosis Code D56.2
Delta-beta thalassemia
Applicable To
- Homozygous delta-beta thalassemia
Type 1 Excludes
- delta-beta thalassemia minor (D56.3)
- delta-beta thalassemia trait (D56.3)
D56.2
)
hemoglobin E-beta thalassemia (
ICD-10-CM Diagnosis Code D56.5
Hemoglobin E-beta thalassemia
Type 1 Excludes
- beta thalassemia (D56.1)
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- delta-beta thalassemia trait (D56.3)
- hemoglobin E disease (D58.2)
- other hemoglobinopathies (D58.2)
- sickle-cell beta thalassemia (D57.4-)
D56.5
)
sickle-cell trait (
ICD-10-CM Diagnosis Code D57.3
Sickle-cell trait
Applicable To
- Hb-S trait
- Heterozygous hemoglobin S
D57.3
)

The following code(s) above D56.3 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D56.3:

D50-D89
2023 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D56
ICD-10-CM Diagnosis Code D56
Thalassemia
Type 1 Excludes
- sickle-cell thalassemia (D57.4-)
Thalassemia

Approximate Synonyms

Alpha thalassemia 2 trait
Alpha trait thalassemia
Beta thalassemia trait
Delta beta thalassemia trait
Hemoglobin lepore trait
Heterozygous thalassemia
Hgb lepore trait
Homozygous hemoglobin lepore
Homozygous hgb lepore
Thalassemia trait
Thalassemia trait, alpha
Thalassemia trait, beta

Clinical Information

A condition in which a person has reduced protein production from one of the four alpha-globin alleles.
A condition in which a person has reduced protein production from two of the four alpha-globin alleles.

ICD-10-CM D56.3 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):

811 Red blood cell disorders with mcc
812 Red blood cell disorders without mcc

Convert D56.3 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change
2023 (effective 10/1/2022): No change

Code annotations containing back-references to D56.3:

Type 1 Excludes: D56.0
, D56.0
, D56.1
, D56.1
, D56.2
, D56.2
, D56.5
, D56.5
, D56.5

ICD-10-CM Diagnosis Code D56.0
Alpha thalassemia
Applicable To
- Alpha thalassemia major
- Hemoglobin H Constant Spring
- Hemoglobin H disease
- Hydrops fetalis due to alpha thalassemia
- Severe alpha thalassemia
- Triple gene defect alpha thalassemia
Type 1 Excludes
- alpha thalassemia trait or minor (D56.3)
- asymptomatic alpha thalassemia (D56.3)
- hydrops fetalis due to isoimmunization (P56.0)
- hydrops fetalis not due to immune hemolysis (P83.2)
Use Additional
- code, if applicable, for hydrops fetalis due to alpha thalassemia (P56.99)
ICD-10-CM Diagnosis Code D56.0
Alpha thalassemia
Applicable To
- Alpha thalassemia major
- Hemoglobin H Constant Spring
- Hemoglobin H disease
- Hydrops fetalis due to alpha thalassemia
- Severe alpha thalassemia
- Triple gene defect alpha thalassemia
Type 1 Excludes
- alpha thalassemia trait or minor (D56.3)
- asymptomatic alpha thalassemia (D56.3)
- hydrops fetalis due to isoimmunization (P56.0)
- hydrops fetalis not due to immune hemolysis (P83.2)
Use Additional
- code, if applicable, for hydrops fetalis due to alpha thalassemia (P56.99)
ICD-10-CM Diagnosis Code D56.1
Beta thalassemia
Applicable To
- Beta thalassemia major
- Cooley's anemia
- Homozygous beta thalassemia
- Severe beta thalassemia
- Thalassemia intermedia
- Thalassemia major
Type 1 Excludes
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell beta thalassemia (D57.4-)
ICD-10-CM Diagnosis Code D56.1
Beta thalassemia
Applicable To
- Beta thalassemia major
- Cooley's anemia
- Homozygous beta thalassemia
- Severe beta thalassemia
- Thalassemia intermedia
- Thalassemia major
Type 1 Excludes
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell beta thalassemia (D57.4-)
ICD-10-CM Diagnosis Code D56.2
Delta-beta thalassemia
Applicable To
- Homozygous delta-beta thalassemia
Type 1 Excludes
- delta-beta thalassemia minor (D56.3)
- delta-beta thalassemia trait (D56.3)
ICD-10-CM Diagnosis Code D56.2
Delta-beta thalassemia
Applicable To
- Homozygous delta-beta thalassemia
Type 1 Excludes
- delta-beta thalassemia minor (D56.3)
- delta-beta thalassemia trait (D56.3)
ICD-10-CM Diagnosis Code D56.5
Hemoglobin E-beta thalassemia
Type 1 Excludes
- beta thalassemia (D56.1)
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- delta-beta thalassemia trait (D56.3)
- hemoglobin E disease (D58.2)
- other hemoglobinopathies (D58.2)
- sickle-cell beta thalassemia (D57.4-)
ICD-10-CM Diagnosis Code D56.5
Hemoglobin E-beta thalassemia
Type 1 Excludes
- beta thalassemia (D56.1)
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- delta-beta thalassemia trait (D56.3)
- hemoglobin E disease (D58.2)
- other hemoglobinopathies (D58.2)
- sickle-cell beta thalassemia (D57.4-)
ICD-10-CM Diagnosis Code D56.5
Hemoglobin E-beta thalassemia
Type 1 Excludes
- beta thalassemia (D56.1)
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- delta-beta thalassemia trait (D56.3)
- hemoglobin E disease (D58.2)
- other hemoglobinopathies (D58.2)
- sickle-cell beta thalassemia (D57.4-)

Diagnosis Index entries containing back-references to D56.3:

Thalassemia (anemia) (disease) D56.9
ICD-10-CM Diagnosis Code D56.9
Thalassemia, unspecified
Applicable To
Mediterranean anemia (with other hemoglobinopathy)
- alpha (major) (severe) (triple gene defect) D56.0
  ICD-10-CM Diagnosis Code D56.0
  Alpha thalassemia
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Applicable To
  Alpha thalassemia major
  Hemoglobin H Constant Spring
  Hemoglobin H disease
  Hydrops fetalis due to alpha thalassemia
  Severe alpha thalassemia
  Triple gene defect alpha thalassemia
  Type 1 Excludes
  alpha thalassemia trait or minor (D56.3)
  asymptomatic alpha thalassemia (D56.3)
  hydrops fetalis due to isoimmunization (P56.0)
  hydrops fetalis not due to immune hemolysis (P83.2)
  Use Additional
  code, if applicable, for hydrops fetalis due to alpha thalassemia (P56.99)
  - minor D56.3
  - silent carrier D56.3
  - trait D56.3
- beta (severe) D56.1
  ICD-10-CM Diagnosis Code D56.1
  Beta thalassemia
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Applicable To
  Beta thalassemia major
  Cooley's anemia
  Homozygous beta thalassemia
  Severe beta thalassemia
  Thalassemia intermedia
  Thalassemia major
  Type 1 Excludes
  beta thalassemia minor (D56.3)
  beta thalassemia trait (D56.3)
  delta-beta thalassemia (D56.2)
  hemoglobin E-beta thalassemia (D56.5)
  sickle-cell beta thalassemia (D57.4-)
  - minor D56.3
  - trait D56.3
- delta-beta (homozygous) D56.2
  ICD-10-CM Diagnosis Code D56.2
  Delta-beta thalassemia
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Applicable To
  Homozygous delta-beta thalassemia
  Type 1 Excludes
  delta-beta thalassemia minor (D56.3)
  delta-beta thalassemia trait (D56.3)
  - minor D56.3
  - trait D56.3
- minor D56.3
- trait D56.3
Trait(s)
- hemoglobin
  - abnormal NEC D58.2
    ICD-10-CM Diagnosis Code D58.2
    Other hemoglobinopathies
    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Applicable To
    Abnormal hemoglobin NOS
    Congenital Heinz body anemia
    Hb-C disease
    Hb-D disease
    Hb-E disease
    Hemoglobinopathy NOS
    Unstable hemoglobin hemolytic disease
    Type 1 Excludes
    familial polycythemia (D75.0)
    Hb-M disease (D74.0)
    hemoglobin E-beta thalassemia (D56.5)
    hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
    high-altitude polycythemia (D75.1)
    methemoglobinemia (D74.-)
    other hemoglobinopathies with thalassemia (D56.8)
    - with thalassemia D56.3
- Lepore D56.3

ICD-10-CM Codes Adjacent To D56.3

D55.2 Anemia due to disorders of glycolytic enzymes

D55.21 Anemia due to pyruvate kinase deficiency

D55.29 Anemia due to other disorders of glycolytic enzymes

D55.3 Anemia due to disorders of nucleotide metabolism

D55.8 Other anemias due to enzyme disorders

D55.9 Anemia due to enzyme disorder, unspecified

D56 Thalassemia

D56.0 Alpha thalassemia

D56.1 Beta thalassemia

D56.2 Delta-beta thalassemia

D56.3 Thalassemia minor

D56.4 Hereditary persistence of fetal hemoglobin [HPFH]

D56.5 Hemoglobin E-beta thalassemia

D56.8 Other thalassemias

D56.9 Thalassemia, unspecified

D57 Sickle-cell disorders

D57.0 Hb-SS disease with crisis

D57.00 …… unspecified

D57.01 Hb-SS disease with acute chest syndrome

D57.02 Hb-SS disease with splenic sequestration

D57.03 Hb-SS disease with cerebral vascular involvement

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2023 ICD-10-CM Diagnosis Code D56.3

Thalassemia minor

Alpha thalassemia

Beta thalassemia

Delta-beta thalassemia

Hemoglobin E-beta thalassemia

Sickle-cell trait

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Thalassemia

Alpha thalassemia

Alpha thalassemia

Beta thalassemia

Beta thalassemia

Delta-beta thalassemia

Delta-beta thalassemia

Hemoglobin E-beta thalassemia

Hemoglobin E-beta thalassemia

Hemoglobin E-beta thalassemia

Thalassemia, unspecified

Alpha thalassemia

Beta thalassemia

Delta-beta thalassemia

Other hemoglobinopathies