ICD-10-CM Codes
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D55-D59 Hemolytic anemias
D56- Thalassemia
2021 ICD-10-CM Diagnosis Code D56.5

2021 ICD-10-CM Diagnosis Code D56.5

Hemoglobin E-beta thalassemia

2016

2017

2018

2019

2020

2021

Billable/Specific Code

D56.5 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2021 edition of ICD-10-CM D56.5 became effective on October 1, 2020.
This is the American ICD-10-CM version of D56.5 - other international versions of ICD-10 D56.5 may differ.

Type 1 Excludes

Type 1 Excludes Help

A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D56.5. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

beta thalassemia (
ICD-10-CM Diagnosis Code D56.1
Beta thalassemia
Applicable To
- Beta thalassemia major
- Cooley's anemia
- Homozygous beta thalassemia
- Severe beta thalassemia
- Thalassemia intermedia
- Thalassemia major
Type 1 Excludes
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell beta thalassemia (D57.4-)
D56.1
)
beta thalassemia minor (
ICD-10-CM Diagnosis Code D56.3
Thalassemia minor
Applicable To
- Alpha thalassemia minor
- Alpha thalassemia silent carrier
- Alpha thalassemia trait
- Beta thalassemia minor
- Beta thalassemia trait
- Delta-beta thalassemia minor
- Delta-beta thalassemia trait
- Thalassemia trait NOS
Type 1 Excludes
- alpha thalassemia (D56.0)
- beta thalassemia (D56.1)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell trait (D57.3)
D56.3
)
beta thalassemia trait (
ICD-10-CM Diagnosis Code D56.3
Thalassemia minor
Applicable To
- Alpha thalassemia minor
- Alpha thalassemia silent carrier
- Alpha thalassemia trait
- Beta thalassemia minor
- Beta thalassemia trait
- Delta-beta thalassemia minor
- Delta-beta thalassemia trait
- Thalassemia trait NOS
Type 1 Excludes
- alpha thalassemia (D56.0)
- beta thalassemia (D56.1)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell trait (D57.3)
D56.3
)
delta-beta thalassemia (
ICD-10-CM Diagnosis Code D56.2
Delta-beta thalassemia
Applicable To
- Homozygous delta-beta thalassemia
Type 1 Excludes
- delta-beta thalassemia minor (D56.3)
- delta-beta thalassemia trait (D56.3)
D56.2
)
delta-beta thalassemia trait (
ICD-10-CM Diagnosis Code D56.3
Thalassemia minor
Applicable To
- Alpha thalassemia minor
- Alpha thalassemia silent carrier
- Alpha thalassemia trait
- Beta thalassemia minor
- Beta thalassemia trait
- Delta-beta thalassemia minor
- Delta-beta thalassemia trait
- Thalassemia trait NOS
Type 1 Excludes
- alpha thalassemia (D56.0)
- beta thalassemia (D56.1)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell trait (D57.3)
D56.3
)
hemoglobin E disease (
ICD-10-CM Diagnosis Code D58.2
Other hemoglobinopathies
Applicable To
- Abnormal hemoglobin NOS
- Congenital Heinz body anemia
- Hb-C disease
- Hb-D disease
- Hb-E disease
- Hemoglobinopathy NOS
- Unstable hemoglobin hemolytic disease
Type 1 Excludes
- familial polycythemia (D75.0)
- Hb-M disease (D74.0)
- hemoglobin E-beta thalassemia (D56.5)
- hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
- high-altitude polycythemia (D75.1)
- methemoglobinemia (D74.-)
- other hemoglobinopathies with thalassemia (D56.8)
D58.2
)
other hemoglobinopathies (
ICD-10-CM Diagnosis Code D58.2
Other hemoglobinopathies
Applicable To
- Abnormal hemoglobin NOS
- Congenital Heinz body anemia
- Hb-C disease
- Hb-D disease
- Hb-E disease
- Hemoglobinopathy NOS
- Unstable hemoglobin hemolytic disease
Type 1 Excludes
- familial polycythemia (D75.0)
- Hb-M disease (D74.0)
- hemoglobin E-beta thalassemia (D56.5)
- hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
- high-altitude polycythemia (D75.1)
- methemoglobinemia (D74.-)
- other hemoglobinopathies with thalassemia (D56.8)
D58.2
)
sickle-cell beta thalassemia (
ICD-10-CM Diagnosis Code D57.4
Sickle-cell thalassemia
Applicable To
- Sickle-cell beta thalassemia
- Thalassemia Hb-S disease
D57.4-
)

The following code(s) above D56.5 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D56.5:

D50-D89
2021 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D56
ICD-10-CM Diagnosis Code D56
Thalassemia
Type 1 Excludes
- sickle-cell thalassemia (D57.4-)
Thalassemia

Approximate Synonyms

Hemoglobin e/beta thalassemia disease
Thalassemia, hemoglobin e beta

ICD-10-CM D56.5 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):

791 Prematurity with major problems
793 Full term neonate with major problems
811 Red blood cell disorders with mcc
812 Red blood cell disorders without mcc

Convert D56.5 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change

Code annotations containing back-references to D56.5:

Type 1 Excludes: D56.1
, D56.3
, D58.2

ICD-10-CM Diagnosis Code D56.1
Beta thalassemia
Applicable To
- Beta thalassemia major
- Cooley's anemia
- Homozygous beta thalassemia
- Severe beta thalassemia
- Thalassemia intermedia
- Thalassemia major
Type 1 Excludes
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell beta thalassemia (D57.4-)
ICD-10-CM Diagnosis Code D56.3
Thalassemia minor
Applicable To
- Alpha thalassemia minor
- Alpha thalassemia silent carrier
- Alpha thalassemia trait
- Beta thalassemia minor
- Beta thalassemia trait
- Delta-beta thalassemia minor
- Delta-beta thalassemia trait
- Thalassemia trait NOS
Type 1 Excludes
- alpha thalassemia (D56.0)
- beta thalassemia (D56.1)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell trait (D57.3)
ICD-10-CM Diagnosis Code D58.2
Other hemoglobinopathies
Applicable To
- Abnormal hemoglobin NOS
- Congenital Heinz body anemia
- Hb-C disease
- Hb-D disease
- Hb-E disease
- Hemoglobinopathy NOS
- Unstable hemoglobin hemolytic disease
Type 1 Excludes
- familial polycythemia (D75.0)
- Hb-M disease (D74.0)
- hemoglobin E-beta thalassemia (D56.5)
- hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
- high-altitude polycythemia (D75.1)
- methemoglobinemia (D74.-)
- other hemoglobinopathies with thalassemia (D56.8)

Diagnosis Index entries containing back-references to D56.5:

Disease, diseased - see also Syndrome
- hemoglobin or Hb
  - E-beta thalassemia D56.5
Hemoglobin - see also condition
- E-beta thalassemia D56.5
Thalassemia (anemia) (disease) D56.9
ICD-10-CM Diagnosis Code D56.9
Thalassemia, unspecified
Applicable To
Mediterranean anemia (with other hemoglobinopathy)
- hemoglobin
  - E-beta D56.5

ICD-10-CM Codes Adjacent To D56.5

D55.2 Anemia due to disorders of glycolytic enzymes

D55.3 Anemia due to disorders of nucleotide metabolism

D55.8 Other anemias due to enzyme disorders

D55.9 Anemia due to enzyme disorder, unspecified

D56 Thalassemia

D56.0 Alpha thalassemia

D56.1 Beta thalassemia

D56.2 Delta-beta thalassemia

D56.3 Thalassemia minor

D56.4 Hereditary persistence of fetal hemoglobin [HPFH]

D56.5 Hemoglobin E-beta thalassemia

D56.8 Other thalassemias

D56.9 Thalassemia, unspecified

D57 Sickle-cell disorders

D57.0 Hb-SS disease with crisis

D57.00 …… unspecified

D57.01 Hb-SS disease with acute chest syndrome

D57.02 Hb-SS disease with splenic sequestration

D57.03 Hb-SS disease with cerebral vascular involvement

D57.09 …… with other specified complication

D57.1 Sickle-cell disease without crisis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2021 ICD-10-CM Diagnosis Code D56.5

Hemoglobin E-beta thalassemia

Beta thalassemia

Thalassemia minor

Thalassemia minor

Delta-beta thalassemia

Thalassemia minor

Other hemoglobinopathies

Other hemoglobinopathies

Sickle-cell thalassemia

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Thalassemia

Beta thalassemia

Thalassemia minor

Other hemoglobinopathies

Thalassemia, unspecified