2020

  1. ICD-10-CM Codes
    2. ›
  2. D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    3. ›
  3. D55-D59 Hemolytic anemias
    4. ›
  4. D56- Thalassemia
    5. ›
  5. 2020 ICD-10-CM Diagnosis Code D56.5

2020 ICD-10-CM Diagnosis Code D56.5

Hemoglobin E-beta thalassemia

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D56.5 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D56.5 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D56.5 - other international versions of ICD-10 D56.5 may differ.
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D56.5. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • beta thalassemia (
    ICD-10-CM Diagnosis Code D56.1

    Beta thalassemia

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Beta thalassemia major
    • Cooley's anemia
    • Homozygous beta thalassemia
    • Severe beta thalassemia
    • Thalassemia intermedia
    • Thalassemia major
    Type 1 Excludes
    • beta thalassemia minor (D56.3)
    • beta thalassemia trait (D56.3)
    • delta-beta thalassemia (D56.2)
    • hemoglobin E-beta thalassemia (D56.5)
    • sickle-cell beta thalassemia (D57.4-)
    D56.1
    )
  • beta thalassemia minor (
    ICD-10-CM Diagnosis Code D56.3

    Thalassemia minor

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Alpha thalassemia minor
    • Alpha thalassemia silent carrier
    • Alpha thalassemia trait
    • Beta thalassemia minor
    • Beta thalassemia trait
    • Delta-beta thalassemia minor
    • Delta-beta thalassemia trait
    • Thalassemia trait NOS
    Type 1 Excludes
    • alpha thalassemia (D56.0)
    • beta thalassemia (D56.1)
    • delta-beta thalassemia (D56.2)
    • hemoglobin E-beta thalassemia (D56.5)
    • sickle-cell trait (D57.3)
    D56.3
    )
  • beta thalassemia trait (
    ICD-10-CM Diagnosis Code D56.3

    Thalassemia minor

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Alpha thalassemia minor
    • Alpha thalassemia silent carrier
    • Alpha thalassemia trait
    • Beta thalassemia minor
    • Beta thalassemia trait
    • Delta-beta thalassemia minor
    • Delta-beta thalassemia trait
    • Thalassemia trait NOS
    Type 1 Excludes
    • alpha thalassemia (D56.0)
    • beta thalassemia (D56.1)
    • delta-beta thalassemia (D56.2)
    • hemoglobin E-beta thalassemia (D56.5)
    • sickle-cell trait (D57.3)
    D56.3
    )
  • delta-beta thalassemia (
    ICD-10-CM Diagnosis Code D56.2

    Delta-beta thalassemia

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Homozygous delta-beta thalassemia
    Type 1 Excludes
    • delta-beta thalassemia minor (D56.3)
    • delta-beta thalassemia trait (D56.3)
    D56.2
    )
  • delta-beta thalassemia trait (
    ICD-10-CM Diagnosis Code D56.3

    Thalassemia minor

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Alpha thalassemia minor
    • Alpha thalassemia silent carrier
    • Alpha thalassemia trait
    • Beta thalassemia minor
    • Beta thalassemia trait
    • Delta-beta thalassemia minor
    • Delta-beta thalassemia trait
    • Thalassemia trait NOS
    Type 1 Excludes
    • alpha thalassemia (D56.0)
    • beta thalassemia (D56.1)
    • delta-beta thalassemia (D56.2)
    • hemoglobin E-beta thalassemia (D56.5)
    • sickle-cell trait (D57.3)
    D56.3
    )
  • hemoglobin E disease (
    ICD-10-CM Diagnosis Code D58.2

    Other hemoglobinopathies

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Abnormal hemoglobin NOS
    • Congenital Heinz body anemia
    • Hb-C disease
    • Hb-D disease
    • Hb-E disease
    • Hemoglobinopathy NOS
    • Unstable hemoglobin hemolytic disease
    Type 1 Excludes
    • familial polycythemia (D75.0)
    • Hb-M disease (D74.0)
    • hemoglobin E-beta thalassemia (D56.5)
    • hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
    • high-altitude polycythemia (D75.1)
    • methemoglobinemia (D74.-)
    • other hemoglobinopathies with thalassemia (D56.8)
    D58.2
    )
  • other hemoglobinopathies (
    ICD-10-CM Diagnosis Code D58.2

    Other hemoglobinopathies

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Abnormal hemoglobin NOS
    • Congenital Heinz body anemia
    • Hb-C disease
    • Hb-D disease
    • Hb-E disease
    • Hemoglobinopathy NOS
    • Unstable hemoglobin hemolytic disease
    Type 1 Excludes
    • familial polycythemia (D75.0)
    • Hb-M disease (D74.0)
    • hemoglobin E-beta thalassemia (D56.5)
    • hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
    • high-altitude polycythemia (D75.1)
    • methemoglobinemia (D74.-)
    • other hemoglobinopathies with thalassemia (D56.8)
    D58.2
    )
  • sickle-cell beta thalassemia (
    ICD-10-CM Diagnosis Code D57.4

    Sickle-cell thalassemia

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Sickle-cell beta thalassemia
    • Thalassemia Hb-S disease
    D57.4-
    )
The following code(s) above D56.5 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D56.5:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D56
    ICD-10-CM Diagnosis Code D56

    Thalassemia

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • sickle-cell thalassemia (D57.4-)
    Thalassemia
Approximate Synonyms
  • Hemoglobin e/beta thalassemia disease
  • Thalassemia, hemoglobin e beta
ICD-10-CM D56.5 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc

Convert D56.5 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to D56.5:
  • Type 1 Excludes: D56.3
    , D58.2
    , D56.1
    ICD-10-CM Diagnosis Code D56.3

    Thalassemia minor

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Alpha thalassemia minor
    • Alpha thalassemia silent carrier
    • Alpha thalassemia trait
    • Beta thalassemia minor
    • Beta thalassemia trait
    • Delta-beta thalassemia minor
    • Delta-beta thalassemia trait
    • Thalassemia trait NOS
    Type 1 Excludes
    • alpha thalassemia (D56.0)
    • beta thalassemia (D56.1)
    • delta-beta thalassemia (D56.2)
    • hemoglobin E-beta thalassemia (D56.5)
    • sickle-cell trait (D57.3)
    ICD-10-CM Diagnosis Code D58.2

    Other hemoglobinopathies

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Abnormal hemoglobin NOS
    • Congenital Heinz body anemia
    • Hb-C disease
    • Hb-D disease
    • Hb-E disease
    • Hemoglobinopathy NOS
    • Unstable hemoglobin hemolytic disease
    Type 1 Excludes
    • familial polycythemia (D75.0)
    • Hb-M disease (D74.0)
    • hemoglobin E-beta thalassemia (D56.5)
    • hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
    • high-altitude polycythemia (D75.1)
    • methemoglobinemia (D74.-)
    • other hemoglobinopathies with thalassemia (D56.8)
    ICD-10-CM Diagnosis Code D56.1

    Beta thalassemia

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Beta thalassemia major
    • Cooley's anemia
    • Homozygous beta thalassemia
    • Severe beta thalassemia
    • Thalassemia intermedia
    • Thalassemia major
    Type 1 Excludes
    • beta thalassemia minor (D56.3)
    • beta thalassemia trait (D56.3)
    • delta-beta thalassemia (D56.2)
    • hemoglobin E-beta thalassemia (D56.5)
    • sickle-cell beta thalassemia (D57.4-)

Diagnosis Index entries containing back-references to D56.5:

ICD-10-CM Codes Adjacent To D56.5
D55.2 Anemia due to disorders of glycolytic enzymes
D55.3 Anemia due to disorders of nucleotide metabolism
D55.8 Other anemias due to enzyme disorders
D55.9 Anemia due to enzyme disorder, unspecified
D56 Thalassemia
D56.0 Alpha thalassemia
D56.1 Beta thalassemia
D56.2 Delta-beta thalassemia
D56.3 Thalassemia minor
D56.4 Hereditary persistence of fetal hemoglobin [HPFH]
D56.5 Hemoglobin E-beta thalassemia
D56.8 Other thalassemias
D56.9 Thalassemia, unspecified
D57 Sickle-cell disorders
D57.0 Hb-SS disease with crisis
D57.00 …… unspecified
D57.01 Hb-SS disease with acute chest syndrome
D57.02 Hb-SS disease with splenic sequestration
D57.1 Sickle-cell disease without crisis
D57.2 Sickle-cell/Hb-C disease
D57.20 …… without crisis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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