2021 ICD-10-CM Diagnosis Code D56.9

Thalassemia, unspecified

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • D56.9 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM D56.9 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D56.9 - other international versions of ICD-10 D56.9 may differ.
Applicable To
  • Mediterranean anemia (with other hemoglobinopathy)
The following code(s) above D56.9 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D56.9:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D56
    ICD-10-CM Diagnosis Code D56


      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • sickle-cell thalassemia (D57.4-)
Approximate Synonyms
  • Maternal thalassemia in childbirth
  • Maternal thalassemia in pregnancy
  • Postpartum (after childbirth) maternal thalassemia
  • Thalassemia
  • Thalassemia in pregnancy
  • Thalassemia postpartum
Clinical Information
  • A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.
  • An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that form hemoglobin. Anemia results from this abnormal hemoglobin formation.
  • An inherited form of anemia
  • Heterogeneous group of hereditary hemolytic anemias which have in common a decreased rate of synthesis of one or more hemoglobin polypeptide chains.
  • If you have thalassemia, your body has problems making hemoglobin, the protein in red blood cells that carries oxygen through your body. When your blood does not carry enough oxygen to the rest of your body, you have anemia.thalassemia, a genetic disease, can be mild or severe. Some carriers of the gene have no symptoms. The most common severe form in the United States is a type called cooley's anemia. It mainly affects people of mediterranean or asian ancestry. It usually appears during the first two years of life. Severe thalassemia is treated with blood transfusions and treatment to remove excess iron in the blood.
ICD-10-CM D56.9 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc

Convert D56.9 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change

Diagnosis Index entries containing back-references to D56.9:
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
    ICD-10-CM Diagnosis Code D64.9

    Anemia, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    • Mediterranean D56.9 (with other hemoglobinopathy)
    • microelliptopoikilocytic D56.9 (Rietti-Greppi- Micheli)
    • Rietti-Greppi-Micheli D56.9
    • thalassemia D56.9
  • Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90
    ICD-10-CM Diagnosis Code M19.90

    Unspecified osteoarthritis, unspecified site

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Arthrosis NOS
    • Arthritis NOS
    • Osteoarthritis NOS
    • in (due to)
      • thalassemia NEC D56.9
  • Disease, diseased - see also Syndrome
    • hemoglobin or Hb
      • abnormal (mixed) D58.2
        ICD-10-CM Diagnosis Code D58.2

        Other hemoglobinopathies

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Abnormal hemoglobin NOS
        • Congenital Heinz body anemia
        • Hb-C disease
        • Hb-D disease
        • Hb-E disease
        • Hemoglobinopathy NOS
        • Unstable hemoglobin hemolytic disease
        Type 1 Excludes
        • familial polycythemia (D75.0)
        • Hb-M disease (D74.0)
        • hemoglobin E-beta thalassemia (D56.5)
        • hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
        • high-altitude polycythemia (D75.1)
        • methemoglobinemia (D74.-)
        • other hemoglobinopathies with thalassemia (D56.8)
        • with thalassemia D56.9
      • H (Hb-H) (thalassemia) D56.0
        ICD-10-CM Diagnosis Code D56.0

        Alpha thalassemia

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Alpha thalassemia major
        • Hemoglobin H Constant Spring
        • Hemoglobin H disease
        • Hydrops fetalis due to alpha thalassemia
        • Severe alpha thalassemia
        • Triple gene defect alpha thalassemia
        Type 1 Excludes
        • alpha thalassemia trait or minor (D56.3)
        • asymptomatic alpha thalassemia (D56.3)
        • hydrops fetalis due to isoimmunization (P56.0)
        • hydrops fetalis not due to immune hemolysis (P83.2)
        Use Additional
        • code, if applicable, for hydrops fetalis due to alpha thalassemia (P56.99)
        • with other abnormal hemoglobin NEC D56.9
      • I thalassemia D56.9
    • high fetal gene or hemoglobin thalassemia D56.9
  • Leptocytosis, hereditary D56.9
  • Rietti-Greppi-Micheli anemia D56.9
  • Thalassemia (anemia) (disease) D56.9

ICD-10-CM Codes Adjacent To D56.9
D55.8 Other anemias due to enzyme disorders
D55.9 Anemia due to enzyme disorder, unspecified
D56 Thalassemia
D56.0 Alpha thalassemia
D56.1 Beta thalassemia
D56.2 Delta-beta thalassemia
D56.3 Thalassemia minor
D56.4 Hereditary persistence of fetal hemoglobin [HPFH]
D56.5 Hemoglobin E-beta thalassemia
D56.8 Other thalassemias
D56.9 Thalassemia, unspecified
D57 Sickle-cell disorders
D57.0 Hb-SS disease with crisis
D57.00 …… unspecified
D57.01 Hb-SS disease with acute chest syndrome
D57.02 Hb-SS disease with splenic sequestration
D57.03 Hb-SS disease with cerebral vascular involvement
D57.09 …… with other specified complication
D57.1 Sickle-cell disease without crisis
D57.2 Sickle-cell/Hb-C disease
D57.20 …… without crisis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.