ICD-10-CM Codes
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D55-D59 Hemolytic anemias
D57- Sickle-cell disorders
2021 ICD-10-CM Diagnosis Code D57.2

2021 ICD-10-CM Diagnosis Code D57.2

Sickle-cell/Hb-C disease

2016

2017

2018

2019

2020

2021

Non-Billable/Non-Specific Code

D57.2 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
The 2021 edition of ICD-10-CM D57.2 became effective on October 1, 2020.
This is the American ICD-10-CM version of D57.2 - other international versions of ICD-10 D57.2 may differ.

Applicable To

Hb-SC disease
Hb-S/Hb-C disease

The following code(s) above D57.2 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D57.2:

D50-D89
2021 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D57
ICD-10-CM Diagnosis Code D57
Sickle-cell disorders
Type 1 Excludes
- other hemoglobinopathies (D58.-)
Use Additional
- code for any associated fever (R50.81)
Sickle-cell disorders

Clinical Information

One of the sickle cell disorders characterized by the presence of both hemoglobin s and hemoglobin c. It is similar to, but less severe than sickle cell anemia.

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change

Diagnosis Index entries containing back-references to D57.2:

Disease, diseased - see also Syndrome
- hemoglobin or Hb
  - C (Hb-C) D58.2
    ICD-10-CM Diagnosis Code D58.2
    Other hemoglobinopathies
    2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    Abnormal hemoglobin NOS
    Congenital Heinz body anemia
    Hb-C disease
    Hb-D disease
    Hb-E disease
    Hemoglobinopathy NOS
    Unstable hemoglobin hemolytic disease
    Type 1 Excludes
    familial polycythemia (D75.0)
    Hb-M disease (D74.0)
    hemoglobin E-beta thalassemia (D56.5)
    hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
    high-altitude polycythemia (D75.1)
    methemoglobinemia (D74.-)
    other hemoglobinopathies with thalassemia (D56.8)
    - Hb-S D57.2-
    - sickle-cell D57.2-
  - SC D57.2-

ICD-10-CM Codes Adjacent To D57.2

D56.8 Other thalassemias

D56.9 Thalassemia, unspecified

D57 Sickle-cell disorders

D57.0 Hb-SS disease with crisis

D57.00 …… unspecified

D57.01 Hb-SS disease with acute chest syndrome

D57.02 Hb-SS disease with splenic sequestration

D57.03 Hb-SS disease with cerebral vascular involvement

D57.09 …… with other specified complication

D57.1 Sickle-cell disease without crisis

D57.2 Sickle-cell/Hb-C disease

D57.20 …… without crisis

D57.21 Sickle-cell/Hb-C disease with crisis

D57.211 Sickle-cell/Hb-C disease with acute chest syndrome

D57.212 Sickle-cell/Hb-C disease with splenic sequestration

D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement

D57.218 …… with other specified complication

D57.219 …… unspecified

D57.3 Sickle-cell trait

D57.4 Sickle-cell thalassemia

D57.40 …… without crisis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2021 ICD-10-CM Diagnosis Code D57.2

Sickle-cell/Hb-C disease

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Sickle-cell disorders

Other hemoglobinopathies