2021 ICD-10-CM Diagnosis Code D57.2

Sickle-cell/Hb-C disease

    2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
  • D57.2 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2021 edition of ICD-10-CM D57.2 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D57.2 - other international versions of ICD-10 D57.2 may differ.
Applicable To
  • Hb-SC disease
  • Hb-S/Hb-C disease
The following code(s) above D57.2 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D57.2:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D57
    ICD-10-CM Diagnosis Code D57

    Sickle-cell disorders

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • other hemoglobinopathies (D58.-)
    Use Additional
    • code for any associated fever (R50.81)
    Sickle-cell disorders
Clinical Information
  • One of the sickle cell disorders characterized by the presence of both hemoglobin s and hemoglobin c. It is similar to, but less severe than sickle cell anemia.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change

Diagnosis Index entries containing back-references to D57.2:
  • Disease, diseased - see also Syndrome
    • hemoglobin or Hb
      • C (Hb-C) D58.2
        ICD-10-CM Diagnosis Code D58.2

        Other hemoglobinopathies

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Abnormal hemoglobin NOS
        • Congenital Heinz body anemia
        • Hb-C disease
        • Hb-D disease
        • Hb-E disease
        • Hemoglobinopathy NOS
        • Unstable hemoglobin hemolytic disease
        Type 1 Excludes
        • familial polycythemia (D75.0)
        • Hb-M disease (D74.0)
        • hemoglobin E-beta thalassemia (D56.5)
        • hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
        • high-altitude polycythemia (D75.1)
        • methemoglobinemia (D74.-)
        • other hemoglobinopathies with thalassemia (D56.8)
        • Hb-S D57.2-
        • sickle-cell D57.2-
      • SC D57.2-

ICD-10-CM Codes Adjacent To D57.2
D56.8 Other thalassemias
D56.9 Thalassemia, unspecified
D57 Sickle-cell disorders
D57.0 Hb-SS disease with crisis
D57.00 …… unspecified
D57.01 Hb-SS disease with acute chest syndrome
D57.02 Hb-SS disease with splenic sequestration
D57.03 Hb-SS disease with cerebral vascular involvement
D57.09 …… with other specified complication
D57.1 Sickle-cell disease without crisis
D57.2 Sickle-cell/Hb-C disease
D57.20 …… without crisis
D57.21 Sickle-cell/Hb-C disease with crisis
D57.211 Sickle-cell/Hb-C disease with acute chest syndrome
D57.212 Sickle-cell/Hb-C disease with splenic sequestration
D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement
D57.218 …… with other specified complication
D57.219 …… unspecified
D57.3 Sickle-cell trait
D57.4 Sickle-cell thalassemia
D57.40 …… without crisis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.