ICD-10-CM Codes
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D55-D59 Hemolytic anemias
D57- Sickle-cell disorders
2021 ICD-10-CM Diagnosis Code D57.3

2021 ICD-10-CM Diagnosis Code D57.3

Sickle-cell trait

2016

2017

2018

2019

2020

2021

Billable/Specific Code

D57.3 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2021 edition of ICD-10-CM D57.3 became effective on October 1, 2020.
This is the American ICD-10-CM version of D57.3 - other international versions of ICD-10 D57.3 may differ.

Applicable To

Hb-S trait
Heterozygous hemoglobin S

The following code(s) above D57.3 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D57.3:

D50-D89
2021 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D57
ICD-10-CM Diagnosis Code D57
Sickle-cell disorders
Type 1 Excludes
- other hemoglobinopathies (D58.-)
Use Additional
- code for any associated fever (R50.81)
Sickle-cell disorders

Approximate Synonyms

Maternal ickle cell trait in pregnancy
Maternal sickle cell trait in pregnancy
Postpartum (after childbirth) sickle cell trait
Postpartum sickle cell trait
Sickle cell trait
Sickle cell trait in childbirth

Clinical Information

The condition of being heterozygous for hemoglobin s.

ICD-10-CM D57.3 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):

811 Red blood cell disorders with mcc
812 Red blood cell disorders without mcc

Convert D57.3 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change

Code annotations containing back-references to D57.3:

Type 1 Excludes: D56.3

ICD-10-CM Diagnosis Code D56.3
Thalassemia minor
Applicable To
- Alpha thalassemia minor
- Alpha thalassemia silent carrier
- Alpha thalassemia trait
- Beta thalassemia minor
- Beta thalassemia trait
- Delta-beta thalassemia minor
- Delta-beta thalassemia trait
- Thalassemia trait NOS
Type 1 Excludes
- alpha thalassemia (D56.0)
- beta thalassemia (D56.1)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell trait (D57.3)

Diagnosis Index entries containing back-references to D57.3:

Disease, diseased - see also Syndrome
- hemoglobin or Hb
  - AS genotype D57.3
Disorder (of) - see also Disease
- sickle-cell (sickling) (homozygous) - see Disease, sickle-cell
  - heterozygous D57.3
  - trait D57.3
Elliptocytosis (congenital) (hereditary) D58.1
ICD-10-CM Diagnosis Code D58.1
Hereditary elliptocytosis
Applicable To
Elliptocytosis (congenital)
Ovalocytosis (congenital) (hereditary)
- sickle-cell (disease) D57.8-
  ICD-10-CM Diagnosis Code D57.8-
  Other sickle-cell disorders
  2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
  Applicable To
  Hb-SD disease
  Hb-SE disease
  - trait D57.3
Hemoglobin - see also condition
- AS genotype D57.3
- S D57.3 (Hb S)
Sickle-cell
- trait D57.3
Sicklemia - see also Disease, sickle-cell
- trait D57.3
Trait(s)
- hemoglobin
  - S D57.3 (Hb-S)
- sickle-cell D57.3
  - with elliptocytosis or spherocytosis D57.3
- Hb-S D57.3

ICD-10-CM Codes Adjacent To D57.3

D57.09 …… with other specified complication

D57.1 Sickle-cell disease without crisis

D57.2 Sickle-cell/Hb-C disease

D57.20 …… without crisis

D57.21 Sickle-cell/Hb-C disease with crisis

D57.211 Sickle-cell/Hb-C disease with acute chest syndrome

D57.212 Sickle-cell/Hb-C disease with splenic sequestration

D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement

D57.218 …… with other specified complication

D57.219 …… unspecified

D57.3 Sickle-cell trait

D57.4 Sickle-cell thalassemia

D57.40 …… without crisis

D57.41 Sickle-cell thalassemia, unspecified, with crisis

D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome

D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration

D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement

D57.418 …… with other specified complication

D57.419 Sickle-cell thalassemia, unspecified, with crisis

D57.42 …… beta zero without crisis

D57.43 Sickle-cell thalassemia beta zero with crisis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2021 ICD-10-CM Diagnosis Code D57.3

Sickle-cell trait

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Sickle-cell disorders

Thalassemia minor

Hereditary elliptocytosis

Other sickle-cell disorders