2021

  1. ICD-10-CM Codes
    2. ›
  2. D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    3. ›
  3. D55-D59 Hemolytic anemias
    4. ›
  4. D57- Sickle-cell disorders
    5. ›
  5. 2021 ICD-10-CM Diagnosis Code D57.4

2021 ICD-10-CM Diagnosis Code D57.4

Sickle-cell thalassemia

    2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
  • D57.4 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2021 edition of ICD-10-CM D57.4 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D57.4 - other international versions of ICD-10 D57.4 may differ.
Applicable To
  • Sickle-cell beta thalassemia
  • Thalassemia Hb-S disease
The following code(s) above D57.4 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D57.4:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D57
    ICD-10-CM Diagnosis Code D57

    Sickle-cell disorders

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • other hemoglobinopathies (D58.-)
    Use Additional
    • code for any associated fever (R50.81)
    Sickle-cell disorders
Clinical Information
  • Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to D57.4:
  • Type 1 Excludes: D56
    , D56.1
    , D56.5
    , D56.8
    ICD-10-CM Diagnosis Code D56

    Thalassemia

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • sickle-cell thalassemia (D57.4-)
    ICD-10-CM Diagnosis Code D56.1

    Beta thalassemia

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Beta thalassemia major
    • Cooley's anemia
    • Homozygous beta thalassemia
    • Severe beta thalassemia
    • Thalassemia intermedia
    • Thalassemia major
    Type 1 Excludes
    • beta thalassemia minor (D56.3)
    • beta thalassemia trait (D56.3)
    • delta-beta thalassemia (D56.2)
    • hemoglobin E-beta thalassemia (D56.5)
    • sickle-cell beta thalassemia (D57.4-)
    ICD-10-CM Diagnosis Code D56.5

    Hemoglobin E-beta thalassemia

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Type 1 Excludes
    • beta thalassemia (D56.1)
    • beta thalassemia minor (D56.3)
    • beta thalassemia trait (D56.3)
    • delta-beta thalassemia (D56.2)
    • delta-beta thalassemia trait (D56.3)
    • hemoglobin E disease (D58.2)
    • other hemoglobinopathies (D58.2)
    • sickle-cell beta thalassemia (D57.4-)
    ICD-10-CM Diagnosis Code D56.8

    Other thalassemias

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Dominant thalassemia
    • Hemoglobin C thalassemia
    • Mixed thalassemia
    • Thalassemia with other hemoglobinopathy
    Type 1 Excludes
    • hemoglobin C disease (D58.2)
    • hemoglobin E disease (D58.2)
    • other hemoglobinopathies (D58.2)
    • sickle-cell anemia (D57.-)
    • sickle-cell thalassemia (D57.4)
ICD-10-CM Codes Adjacent To D57.4
D57.1 Sickle-cell disease without crisis
D57.2 Sickle-cell/Hb-C disease
D57.20 …… without crisis
D57.21 Sickle-cell/Hb-C disease with crisis
D57.211 Sickle-cell/Hb-C disease with acute chest syndrome
D57.212 Sickle-cell/Hb-C disease with splenic sequestration
D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement
D57.218 …… with other specified complication
D57.219 …… unspecified
D57.3 Sickle-cell trait
D57.4 Sickle-cell thalassemia
D57.40 …… without crisis
D57.41 Sickle-cell thalassemia, unspecified, with crisis
D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome
D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration
D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
D57.418 …… with other specified complication
D57.419 Sickle-cell thalassemia, unspecified, with crisis
D57.42 …… beta zero without crisis
D57.43 Sickle-cell thalassemia beta zero with crisis
D57.431 Sickle-cell thalassemia beta zero with acute chest syndrome

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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