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ICD-10-CM Codes
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D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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D55-D59
Hemolytic anemias
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D57-
Sickle-cell disorders
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2019 ICD-10-CM Diagnosis Code D57.4
Sickle-cell thalassemia
2016 2017 2018 2019 Non-Billable/Non-Specific Code
- D57.4 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
- The 2019 edition of ICD-10-CM D57.4 became effective on October 1, 2018.
- This is the American ICD-10-CM version of D57.4 - other international versions of ICD-10 D57.4 may differ.
Applicable To- Sickle-cell beta thalassemia
- Thalassemia Hb-S disease
The following code(s) above
D57.4 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
D57.4:
- Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene.
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
Code annotations containing back-references to D57.4:
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Type 1 Excludes: D56, D56.1, D56.5, D56.8
ICD-10-CM Diagnosis Code D56
Thalassemia
2016 2017 2018 2019 Non-Billable/Non-Specific Code
Type 1 Excludes- sickle-cell thalassemia (D57.4-)
ICD-10-CM Diagnosis Code D56.1
Beta thalassemia
2016 2017 2018 2019 Billable/Specific Code
Applicable To- Beta thalassemia major
- Cooley's anemia
- Homozygous beta thalassemia
- Severe beta thalassemia
- Thalassemia intermedia
- Thalassemia major
Type 1 Excludes- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell beta thalassemia (D57.4-)
ICD-10-CM Diagnosis Code D56.5
Hemoglobin E-beta thalassemia
2016 2017 2018 2019 Billable/Specific Code
Type 1 Excludes- beta thalassemia (D56.1)
- beta thalassemia minor (D56.3)
- beta thalassemia trait (D56.3)
- delta-beta thalassemia (D56.2)
- delta-beta thalassemia trait (D56.3)
- hemoglobin E disease (D58.2)
- other hemoglobinopathies (D58.2)
- sickle-cell beta thalassemia (D57.4-)
ICD-10-CM Diagnosis Code D56.8
Other thalassemias
2016 2017 2018 2019 Billable/Specific Code
Applicable To- Dominant thalassemia
- Hemoglobin C thalassemia
- Mixed thalassemia
- Thalassemia with other hemoglobinopathy
Type 1 Excludes- hemoglobin C disease (D58.2)
- hemoglobin E disease (D58.2)
- other hemoglobinopathies (D58.2)
- sickle-cell anemia (D57.-)
- sickle-cell thalassemia (D57.4)
ICD-10-CM Codes Adjacent To D57.4
D57.01 Hb-SS disease with acute chest syndrome
D57.02 Hb-SS disease with splenic sequestration
D57.1 Sickle-cell disease without crisis
D57.2 Sickle-cell/Hb-C disease
D57.21 Sickle-cell/Hb-C disease with crisis
D57.211 Sickle-cell/Hb-C disease with acute chest syndrome
D57.212 Sickle-cell/Hb-C disease with splenic sequestration
D57.4
Sickle-cell thalassemia
D57.41 Sickle-cell thalassemia with crisis
D57.411 Sickle-cell thalassemia with acute chest syndrome
D57.412 Sickle-cell thalassemia with splenic sequestration
D57.8 Other sickle-cell disorders
D57.81 Other sickle-cell disorders with crisis
D57.811 Other sickle-cell disorders with acute chest syndrome
D57.812 Other sickle-cell disorders with splenic sequestration
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
