2021 ICD-10-CM Diagnosis Code D57.418

Sickle-cell thalassemia, unspecified, with crisis with other specified complication

    2021 - New Code Billable/Specific Code
  • D57.418 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • Short description: Sickle-cell thalassemia, unsp, with crisis with oth comp
  • ICD-10-CM D57.418 is a new 2021 ICD-10-CM code that became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D57.418 - other international versions of ICD-10 D57.418 may differ.
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code to identify complications, such as:
  • cholelithiasis (
    ICD-10-CM Diagnosis Code K80
    • K80 Cholelithiasis
      • K80.0 Calculus of gallbladder with acute cholecysti...
        • K80.00 Calculus of gallbladder with acute cholecysti...
        • K80.01 Calculus of gallbladder with acute cholecysti...
      • K80.1 Calculus of gallbladder with other cholecysti...
        • K80.10 Calculus of gallbladder with chronic cholecys...
        • K80.11 Calculus of gallbladder with chronic cholecys...
        • K80.12 Calculus of gallbladder with acute and chroni...
        • K80.13 Calculus of gallbladder with acute and chroni...
        • K80.18 Calculus of gallbladder with other cholecysti...
        • K80.19 Calculus of gallbladder with other cholecysti...
      • K80.2 Calculus of gallbladder without cholecystitis...
        • K80.20 Calculus of gallbladder without cholecystitis...
        • K80.21 Calculus of gallbladder without cholecystitis...
      • K80.3 Calculus of bile duct with cholangitis
        • K80.30 Calculus of bile duct with cholangitis, unspe...
        • K80.31 Calculus of bile duct with cholangitis, unspe...
        • K80.32 Calculus of bile duct with acute cholangitis ...
        • K80.33 Calculus of bile duct with acute cholangitis ...
        • K80.34 Calculus of bile duct with chronic cholangiti...
        • K80.35 Calculus of bile duct with chronic cholangiti...
        • K80.36 Calculus of bile duct with acute and chronic ...
        • K80.37 Calculus of bile duct with acute and chronic ...
      • K80.4 Calculus of bile duct with cholecystitis
        • K80.40 Calculus of bile duct with cholecystitis, uns...
        • K80.41 Calculus of bile duct with cholecystitis, uns...
        • K80.42 Calculus of bile duct with acute cholecystiti...
        • K80.43 Calculus of bile duct with acute cholecystiti...
        • K80.44 Calculus of bile duct with chronic cholecysti...
        • K80.45 Calculus of bile duct with chronic cholecysti...
        • K80.46 Calculus of bile duct with acute and chronic ...
        • K80.47 Calculus of bile duct with acute and chronic ...
      • K80.5 Calculus of bile duct without cholangitis or ...
        • K80.50 Calculus of bile duct without cholangitis or ...
        • K80.51 Calculus of bile duct without cholangitis or ...
      • K80.6 Calculus of gallbladder and bile duct with ch...
        • K80.60 Calculus of gallbladder and bile duct with ch...
        • K80.61 Calculus of gallbladder and bile duct with ch...
        • K80.62 Calculus of gallbladder and bile duct with ac...
        • K80.63 Calculus of gallbladder and bile duct with ac...
        • K80.64 Calculus of gallbladder and bile duct with ch...
        • K80.65 Calculus of gallbladder and bile duct with ch...
        • K80.66 Calculus of gallbladder and bile duct with ac...
        • K80.67 Calculus of gallbladder and bile duct with ac...
      • K80.7 Calculus of gallbladder and bile duct without...
        • K80.70 Calculus of gallbladder and bile duct without...
        • K80.71 Calculus of gallbladder and bile duct without...
      • K80.8 Other cholelithiasis
        • K80.80 …… without obstruction
        • K80.81 …… with obstruction
    K80.-
    )
  • priapism (
    ICD-10-CM Diagnosis Code N48.32

    Priapism due to disease classified elsewhere

      2016 2017 2018 2019 2020 2021 Billable/Specific Code Male Dx Manifestation Code
    N48.32
    )
The following code(s) above D57.418 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D57.418:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D57
    ICD-10-CM Diagnosis Code D57

    Sickle-cell disorders

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • other hemoglobinopathies (D58.-)
    Use Additional
    • code for any associated fever (R50.81)
    Sickle-cell disorders
  • D57.4
    ICD-10-CM Diagnosis Code D57.4

    Sickle-cell thalassemia

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Applicable To
    • Sickle-cell beta thalassemia
    • Thalassemia Hb-S disease
    Sickle-cell thalassemia
  • D57.41
    ICD-10-CM Diagnosis Code D57.41

    Sickle-cell thalassemia, unspecified, with crisis

      2016 2017 2018 2019 2020 2021 - Revised Code Non-Billable/Non-Specific Code
    Applicable To
    • Sickle-cell thalassemia with (painful) crisis NOS
    • Sickle-cell thalassemia with vasoocclusive pain NOS
    Sickle-cell thalassemia, unspecified, with crisis
ICD-10-CM D57.418 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc
Code History
  • 2021 (effective 10/1/2020): New code

Diagnosis Index entries containing back-references to D57.418:
  • Disease, diseased - see also Syndrome
    • sickle-cell D57.1
      ICD-10-CM Diagnosis Code D57.1

      Sickle-cell disease without crisis

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • Hb-SS disease without crisis
      • Sickle-cell anemia NOS
      • Sickle-cell disease NOS
      • Sickle-cell disorder NOS
      • thalassemia D57.40
        ICD-10-CM Diagnosis Code D57.40

        Sickle-cell thalassemia without crisis

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Microdrepanocytosis
        • Sickle-cell thalassemia NOS
        • with
          • crisis (painful) D57.419
            ICD-10-CM Diagnosis Code D57.419

            Sickle-cell thalassemia, unspecified, with crisis

              2016 2017 2018 2019 2020 2021 - Revised Code Billable/Specific Code
            Applicable To
            • Sickle-cell thalassemia with (painful) crisis NOS
            • Sickle-cell thalassemia with vasoocclusive pain
            • with specified complication NEC D57.418
  • Hemoglobinopathy (mixed) D58.2
    ICD-10-CM Diagnosis Code D58.2

    Other hemoglobinopathies

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Abnormal hemoglobin NOS
    • Congenital Heinz body anemia
    • Hb-C disease
    • Hb-D disease
    • Hb-E disease
    • Hemoglobinopathy NOS
    • Unstable hemoglobin hemolytic disease
    Type 1 Excludes
    • familial polycythemia (D75.0)
    • Hb-M disease (D74.0)
    • hemoglobin E-beta thalassemia (D56.5)
    • hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
    • high-altitude polycythemia (D75.1)
    • methemoglobinemia (D74.-)
    • other hemoglobinopathies with thalassemia (D56.8)
    • sickle-cell D57.1
      ICD-10-CM Diagnosis Code D57.1

      Sickle-cell disease without crisis

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • Hb-SS disease without crisis
      • Sickle-cell anemia NOS
      • Sickle-cell disease NOS
      • Sickle-cell disorder NOS
      • with thalassemia D57.40
        ICD-10-CM Diagnosis Code D57.40

        Sickle-cell thalassemia without crisis

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Microdrepanocytosis
        • Sickle-cell thalassemia NOS
        • with
          • crisis (painful) D57.419
            ICD-10-CM Diagnosis Code D57.419

            Sickle-cell thalassemia, unspecified, with crisis

              2016 2017 2018 2019 2020 2021 - Revised Code Billable/Specific Code
            Applicable To
            • Sickle-cell thalassemia with (painful) crisis NOS
            • Sickle-cell thalassemia with vasoocclusive pain
            • with specified complication NEC D57.418
  • Microdrepanocytosis D57.40
    ICD-10-CM Diagnosis Code D57.40

    Sickle-cell thalassemia without crisis

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Microdrepanocytosis
    • Sickle-cell thalassemia NOS
    • with
      • crisis (painful) D57.419
        ICD-10-CM Diagnosis Code D57.419

        Sickle-cell thalassemia, unspecified, with crisis

          2016 2017 2018 2019 2020 2021 - Revised Code Billable/Specific Code
        Applicable To
        • Sickle-cell thalassemia with (painful) crisis NOS
        • Sickle-cell thalassemia with vasoocclusive pain
        • with specified complication NEC D57.418

ICD-10-CM Codes Adjacent To D57.418
D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement
D57.218 …… with other specified complication
D57.219 …… unspecified
D57.3 Sickle-cell trait
D57.4 Sickle-cell thalassemia
D57.40 …… without crisis
D57.41 Sickle-cell thalassemia, unspecified, with crisis
D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome
D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration
D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
D57.418 …… with other specified complication
D57.419 Sickle-cell thalassemia, unspecified, with crisis
D57.42 …… beta zero without crisis
D57.43 Sickle-cell thalassemia beta zero with crisis
D57.431 Sickle-cell thalassemia beta zero with acute chest syndrome
D57.432 Sickle-cell thalassemia beta zero with splenic sequestration
D57.433 Sickle-cell thalassemia beta zero with cerebral vascular involvement
D57.438 …… with other specified complication
D57.439 …… unspecified
D57.44 …… beta plus without crisis
D57.45 Sickle-cell thalassemia beta plus with crisis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.