2021 ICD-10-CM Diagnosis Code D57.42

Sickle-cell thalassemia beta zero without crisis

    2021 - New Code Billable/Specific Code
  • D57.42 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • ICD-10-CM D57.42 is a new 2021 ICD-10-CM code that became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D57.42 - other international versions of ICD-10 D57.42 may differ.
Applicable To
  • HbS-beta zero without crisis
  • Sickle-cell beta zero without crisis
The following code(s) above D57.42 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D57.42:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D57
    ICD-10-CM Diagnosis Code D57

    Sickle-cell disorders

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • other hemoglobinopathies (D58.-)
    Use Additional
    • code for any associated fever (R50.81)
    Sickle-cell disorders
  • D57.4
    ICD-10-CM Diagnosis Code D57.4

    Sickle-cell thalassemia

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Applicable To
    • Sickle-cell beta thalassemia
    • Thalassemia Hb-S disease
    Sickle-cell thalassemia
ICD-10-CM D57.42 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc
Code History
  • 2021 (effective 10/1/2020): New code

Diagnosis Index entries containing back-references to D57.42:
  • Disease, diseased - see also Syndrome
    • hemoglobin or Hb
      • S or SS D57.1
        ICD-10-CM Diagnosis Code D57.1

        Sickle-cell disease without crisis

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Hb-SS disease without crisis
        • Sickle-cell anemia NOS
        • Sickle-cell disease NOS
        • Sickle-cell disorder NOS
    • sickle-cell D57.1
      ICD-10-CM Diagnosis Code D57.1

      Sickle-cell disease without crisis

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • Hb-SS disease without crisis
      • Sickle-cell anemia NOS
      • Sickle-cell disease NOS
      • Sickle-cell disorder NOS
      • thalassemia D57.40
        ICD-10-CM Diagnosis Code D57.40

        Sickle-cell thalassemia without crisis

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Microdrepanocytosis
        • Sickle-cell thalassemia NOS

ICD-10-CM Codes Adjacent To D57.42
D57.219 …… unspecified
D57.3 Sickle-cell trait
D57.4 Sickle-cell thalassemia
D57.40 …… without crisis
D57.41 Sickle-cell thalassemia, unspecified, with crisis
D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome
D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration
D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
D57.418 …… with other specified complication
D57.419 Sickle-cell thalassemia, unspecified, with crisis
D57.42 …… beta zero without crisis
D57.43 Sickle-cell thalassemia beta zero with crisis
D57.431 Sickle-cell thalassemia beta zero with acute chest syndrome
D57.432 Sickle-cell thalassemia beta zero with splenic sequestration
D57.433 Sickle-cell thalassemia beta zero with cerebral vascular involvement
D57.438 …… with other specified complication
D57.439 …… unspecified
D57.44 …… beta plus without crisis
D57.45 Sickle-cell thalassemia beta plus with crisis
D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome
D57.452 Sickle-cell thalassemia beta plus with splenic sequestration

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.