2021 ICD-10-CM Diagnosis Code D57.45

Sickle-cell thalassemia beta plus with crisis

    2021 - New Code Non-Billable/Non-Specific Code
  • D57.45 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • ICD-10-CM D57.45 is a new 2021 ICD-10-CM code that became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D57.45 - other international versions of ICD-10 D57.45 may differ.
Applicable To
  • HbS-beta plus with crisis
  • Sickle-cell beta plus with crisis
The following code(s) above D57.45 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D57.45:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D57
    ICD-10-CM Diagnosis Code D57

    Sickle-cell disorders

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • other hemoglobinopathies (D58.-)
    Use Additional
    • code for any associated fever (R50.81)
    Sickle-cell disorders
  • D57.4
    ICD-10-CM Diagnosis Code D57.4

    Sickle-cell thalassemia

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Applicable To
    • Sickle-cell beta thalassemia
    • Thalassemia Hb-S disease
    Sickle-cell thalassemia
Code History
  • 2021 (effective 10/1/2020): New code
ICD-10-CM Codes Adjacent To D57.45
D57.418 …… with other specified complication
D57.419 Sickle-cell thalassemia, unspecified, with crisis
D57.42 …… beta zero without crisis
D57.43 Sickle-cell thalassemia beta zero with crisis
D57.431 Sickle-cell thalassemia beta zero with acute chest syndrome
D57.432 Sickle-cell thalassemia beta zero with splenic sequestration
D57.433 Sickle-cell thalassemia beta zero with cerebral vascular involvement
D57.438 …… with other specified complication
D57.439 …… unspecified
D57.44 …… beta plus without crisis
D57.45 Sickle-cell thalassemia beta plus with crisis
D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome
D57.452 Sickle-cell thalassemia beta plus with splenic sequestration
D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement
D57.458 …… with other specified complication
D57.459 …… unspecified
D57.8 Other sickle-cell disorders
D57.80 …… without crisis
D57.81 Other sickle-cell disorders with crisis
D57.811 Other sickle-cell disorders with acute chest syndrome
D57.812 Other sickle-cell disorders with splenic sequestration

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.