2021 ICD-10-CM Diagnosis Code D57.453

Sickle-cell thalassemia beta plus with cerebral vascular involvement

    2021 - New Code Billable/Specific Code
  • D57.453 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • Short description: Sickle-cell thalassemia beta plus with cereb vascular invl
  • ICD-10-CM D57.453 is a new 2021 ICD-10-CM code that became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D57.453 - other international versions of ICD-10 D57.453 may differ.
Applicable To
  • HbS-beta plus with cerebral vascular involvement
  • Sickle-cell beta plus with cerebral vascular involvement
Code Also
Code Also Help
A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.
  • , if applicable cerebral infarction (
    ICD-10-CM Diagnosis Code I63
    • I63 Cerebral infarction
      • I63.0 Cerebral infarction due to thrombosis of prec...
        • I63.00 Cerebral infarction due to thrombosis of unsp...
        • I63.01 Cerebral infarction due to thrombosis of vert...
          • I63.011 Cerebral infarction due to thrombosis of righ...
          • I63.012 Cerebral infarction due to thrombosis of left...
          • I63.013 Cerebral infarction due to thrombosis of bila...
          • I63.019 Cerebral infarction due to thrombosis of unsp...
        • I63.02 Cerebral infarction due to thrombosis of basi...
        • I63.03 Cerebral infarction due to thrombosis of caro...
          • I63.031 Cerebral infarction due to thrombosis of righ...
          • I63.032 Cerebral infarction due to thrombosis of left...
          • I63.033 Cerebral infarction due to thrombosis of bila...
          • I63.039 Cerebral infarction due to thrombosis of unsp...
        • I63.09 Cerebral infarction due to thrombosis of othe...
      • I63.1 Cerebral infarction due to embolism of precer...
        • I63.10 Cerebral infarction due to embolism of unspec...
        • I63.11 Cerebral infarction due to embolism of verteb...
          • I63.111 Cerebral infarction due to embolism of right ...
          • I63.112 Cerebral infarction due to embolism of left v...
          • I63.113 Cerebral infarction due to embolism of bilate...
          • I63.119 Cerebral infarction due to embolism of unspec...
        • I63.12 Cerebral infarction due to embolism of basila...
        • I63.13 Cerebral infarction due to embolism of caroti...
          • I63.131 Cerebral infarction due to embolism of right ...
          • I63.132 Cerebral infarction due to embolism of left c...
          • I63.133 Cerebral infarction due to embolism of bilate...
          • I63.139 Cerebral infarction due to embolism of unspec...
        • I63.19 Cerebral infarction due to embolism of other ...
      • I63.2 Cerebral infarction due to unspecified occlus...
        • I63.20 Cerebral infarction due to unspecified occlus...
        • I63.21 Cerebral infarction due to unspecified occlus...
          • I63.211 Cerebral infarction due to unspecified occlus...
          • I63.212 Cerebral infarction due to unspecified occlus...
          • I63.213 Cerebral infarction due to unspecified occlus...
          • I63.219 Cerebral infarction due to unspecified occlus...
        • I63.22 Cerebral infarction due to unspecified occlus...
        • I63.23 Cerebral infarction due to unspecified occlus...
          • I63.231 Cerebral infarction due to unspecified occlus...
          • I63.232 Cerebral infarction due to unspecified occlus...
          • I63.233 Cerebral infarction due to unspecified occlus...
          • I63.239 Cerebral infarction due to unspecified occlus...
        • I63.29 Cerebral infarction due to unspecified occlus...
      • I63.3 Cerebral infarction due to thrombosis of cere...
        • I63.30 Cerebral infarction due to thrombosis of unsp...
        • I63.31 Cerebral infarction due to thrombosis of midd...
          • I63.311 Cerebral infarction due to thrombosis of righ...
          • I63.312 Cerebral infarction due to thrombosis of left...
          • I63.313 Cerebral infarction due to thrombosis of bila...
          • I63.319 Cerebral infarction due to thrombosis of unsp...
        • I63.32 Cerebral infarction due to thrombosis of ante...
          • I63.321 Cerebral infarction due to thrombosis of righ...
          • I63.322 Cerebral infarction due to thrombosis of left...
          • I63.323 Cerebral infarction due to thrombosis of bila...
          • I63.329 Cerebral infarction due to thrombosis of unsp...
        • I63.33 Cerebral infarction due to thrombosis of post...
          • I63.331 Cerebral infarction due to thrombosis of righ...
          • I63.332 Cerebral infarction due to thrombosis of left...
          • I63.333 Cerebral infarction due to thrombosis of bila...
          • I63.339 Cerebral infarction due to thrombosis of unsp...
        • I63.34 Cerebral infarction due to thrombosis of cere...
          • I63.341 Cerebral infarction due to thrombosis of righ...
          • I63.342 Cerebral infarction due to thrombosis of left...
          • I63.343 Cerebral infarction due to thrombosis of bila...
          • I63.349 Cerebral infarction due to thrombosis of unsp...
        • I63.39 Cerebral infarction due to thrombosis of othe...
      • I63.4 Cerebral infarction due to embolism of cerebr...
        • I63.40 Cerebral infarction due to embolism of unspec...
        • I63.41 Cerebral infarction due to embolism of middle...
          • I63.411 Cerebral infarction due to embolism of right ...
          • I63.412 Cerebral infarction due to embolism of left m...
          • I63.413 Cerebral infarction due to embolism of bilate...
          • I63.419 Cerebral infarction due to embolism of unspec...
        • I63.42 Cerebral infarction due to embolism of anteri...
          • I63.421 Cerebral infarction due to embolism of right ...
          • I63.422 Cerebral infarction due to embolism of left a...
          • I63.423 Cerebral infarction due to embolism of bilate...
          • I63.429 Cerebral infarction due to embolism of unspec...
        • I63.43 Cerebral infarction due to embolism of poster...
          • I63.431 Cerebral infarction due to embolism of right ...
          • I63.432 Cerebral infarction due to embolism of left p...
          • I63.433 Cerebral infarction due to embolism of bilate...
          • I63.439 Cerebral infarction due to embolism of unspec...
        • I63.44 Cerebral infarction due to embolism of cerebe...
          • I63.441 Cerebral infarction due to embolism of right ...
          • I63.442 Cerebral infarction due to embolism of left c...
          • I63.443 Cerebral infarction due to embolism of bilate...
          • I63.449 Cerebral infarction due to embolism of unspec...
        • I63.49 Cerebral infarction due to embolism of other ...
      • I63.5 Cerebral infarction due to unspecified occlus...
        • I63.50 Cerebral infarction due to unspecified occlus...
        • I63.51 Cerebral infarction due to unspecified occlus...
          • I63.511 Cerebral infarction due to unspecified occlus...
          • I63.512 Cerebral infarction due to unspecified occlus...
          • I63.513 Cerebral infarction due to unspecified occlus...
          • I63.519 Cerebral infarction due to unspecified occlus...
        • I63.52 Cerebral infarction due to unspecified occlus...
          • I63.521 Cerebral infarction due to unspecified occlus...
          • I63.522 Cerebral infarction due to unspecified occlus...
          • I63.523 Cerebral infarction due to unspecified occlus...
          • I63.529 Cerebral infarction due to unspecified occlus...
        • I63.53 Cerebral infarction due to unspecified occlus...
          • I63.531 Cerebral infarction due to unspecified occlus...
          • I63.532 Cerebral infarction due to unspecified occlus...
          • I63.533 Cerebral infarction due to unspecified occlus...
          • I63.539 Cerebral infarction due to unspecified occlus...
        • I63.54 Cerebral infarction due to unspecified occlus...
          • I63.541 Cerebral infarction due to unspecified occlus...
          • I63.542 Cerebral infarction due to unspecified occlus...
          • I63.543 Cerebral infarction due to unspecified occlus...
          • I63.549 Cerebral infarction due to unspecified occlus...
        • I63.59 Cerebral infarction due to unspecified occlus...
      • I63.6 Cerebral infarction due to cerebral venous th...
      • I63.8 Other cerebral infarction
        • I63.81 Other cerebral infarction due to occlusion or...
        • I63.89 Other cerebral infarction
      • I63.9 Cerebral infarction, unspecified
    I63.-
    )
The following code(s) above D57.453 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D57.453:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D57
    ICD-10-CM Diagnosis Code D57

    Sickle-cell disorders

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • other hemoglobinopathies (D58.-)
    Use Additional
    • code for any associated fever (R50.81)
    Sickle-cell disorders
  • D57.4
    ICD-10-CM Diagnosis Code D57.4

    Sickle-cell thalassemia

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Applicable To
    • Sickle-cell beta thalassemia
    • Thalassemia Hb-S disease
    Sickle-cell thalassemia
  • D57.45
    ICD-10-CM Diagnosis Code D57.45

    Sickle-cell thalassemia beta plus with crisis

      2021 - New Code Non-Billable/Non-Specific Code
    Applicable To
    • HbS-beta plus with crisis
    • Sickle-cell beta plus with crisis
    Sickle-cell thalassemia beta plus with crisis
ICD-10-CM D57.453 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc
Code History
  • 2021 (effective 10/1/2020): New code

Diagnosis Index entries containing back-references to D57.453:
  • Disease, diseased - see also Syndrome
    • hemoglobin or Hb
      • S or SS D57.1
        ICD-10-CM Diagnosis Code D57.1

        Sickle-cell disease without crisis

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Hb-SS disease without crisis
        • Sickle-cell anemia NOS
        • Sickle-cell disease NOS
        • Sickle-cell disorder NOS
        • beta plus D57.44
          ICD-10-CM Diagnosis Code D57.44

          Sickle-cell thalassemia beta plus without crisis

            2021 - New Code Billable/Specific Code
          Applicable To
          • HbS-beta plus without crisis
          • Sickle-cell beta plus without crisis
          • with
            • cerebral vascular involvement D57.453
    • sickle-cell D57.1
      ICD-10-CM Diagnosis Code D57.1

      Sickle-cell disease without crisis

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • Hb-SS disease without crisis
      • Sickle-cell anemia NOS
      • Sickle-cell disease NOS
      • Sickle-cell disorder NOS
      • thalassemia D57.40
        ICD-10-CM Diagnosis Code D57.40

        Sickle-cell thalassemia without crisis

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Microdrepanocytosis
        • Sickle-cell thalassemia NOS
        • beta plus D57.44
          ICD-10-CM Diagnosis Code D57.44

          Sickle-cell thalassemia beta plus without crisis

            2021 - New Code Billable/Specific Code
          Applicable To
          • HbS-beta plus without crisis
          • Sickle-cell beta plus without crisis
          • with
            • cerebral vascular involvement D57.453

ICD-10-CM Codes Adjacent To D57.453
D57.43 Sickle-cell thalassemia beta zero with crisis
D57.431 Sickle-cell thalassemia beta zero with acute chest syndrome
D57.432 Sickle-cell thalassemia beta zero with splenic sequestration
D57.433 Sickle-cell thalassemia beta zero with cerebral vascular involvement
D57.438 …… with other specified complication
D57.439 …… unspecified
D57.44 …… beta plus without crisis
D57.45 Sickle-cell thalassemia beta plus with crisis
D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome
D57.452 Sickle-cell thalassemia beta plus with splenic sequestration
D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement
D57.458 …… with other specified complication
D57.459 …… unspecified
D57.8 Other sickle-cell disorders
D57.80 …… without crisis
D57.81 Other sickle-cell disorders with crisis
D57.811 Other sickle-cell disorders with acute chest syndrome
D57.812 Other sickle-cell disorders with splenic sequestration
D57.813 Other sickle-cell disorders with cerebral vascular involvement
D57.818 …… with other specified complication
D57.819 …… unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.