2020 ICD-10-CM Diagnosis Code D58.2

Other hemoglobinopathies

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D58.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D58.2 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D58.2 - other international versions of ICD-10 D58.2 may differ.
Applicable To
  • Abnormal hemoglobin NOS
  • Congenital Heinz body anemia
  • Hb-C disease
  • Hb-D disease
  • Hb-E disease
  • Hemoglobinopathy NOS
  • Unstable hemoglobin hemolytic disease
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D58.2. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • familial polycythemia (
    ICD-10-CM Diagnosis Code D75.0

    Familial erythrocytosis

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Benign polycythemia
    • Familial polycythemia
    Type 1 Excludes
    • hereditary ovalocytosis (D58.1)
    D75.0
    )
  • Hb-M disease (
    ICD-10-CM Diagnosis Code D74.0

    Congenital methemoglobinemia

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Congenital NADH-methemoglobin reductase deficiency
    • Hemoglobin-M [Hb-M] disease
    • Methemoglobinemia, hereditary
    D74.0
    )
  • hemoglobin E-beta thalassemia (
    ICD-10-CM Diagnosis Code D56.5

    Hemoglobin E-beta thalassemia

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • beta thalassemia (D56.1)
    • beta thalassemia minor (D56.3)
    • beta thalassemia trait (D56.3)
    • delta-beta thalassemia (D56.2)
    • delta-beta thalassemia trait (D56.3)
    • hemoglobin E disease (D58.2)
    • other hemoglobinopathies (D58.2)
    • sickle-cell beta thalassemia (D57.4-)
    D56.5
    )
  • hereditary persistence of fetal hemoglobin [HPFH] (
    ICD-10-CM Diagnosis Code D56.4

    Hereditary persistence of fetal hemoglobin [HPFH]

      2016 2017 2018 2019 2020 Billable/Specific Code
    D56.4
    )
  • high-altitude polycythemia (
    ICD-10-CM Diagnosis Code D75.1

    Secondary polycythemia

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Acquired polycythemia
    • Emotional polycythemia
    • Erythrocytosis NOS
    • Hypoxemic polycythemia
    • Nephrogenous polycythemia
    • Polycythemia due to erythropoietin
    • Polycythemia due to fall in plasma volume
    • Polycythemia due to high altitude
    • Polycythemia due to stress
    • Polycythemia NOS
    • Relative polycythemia
    Type 1 Excludes
    • polycythemia neonatorum (P61.1)
    • polycythemia vera (D45)
    D75.1
    )
  • methemoglobinemia (
    ICD-10-CM Diagnosis Code D74
    • D74 Methemoglobinemia
      • D74.0 Congenital methemoglobinemia
      • D74.8 Other methemoglobinemias
      • D74.9 Methemoglobinemia, unspecified
    D74.-
    )
  • other hemoglobinopathies with thalassemia (
    ICD-10-CM Diagnosis Code D56.8

    Other thalassemias

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Dominant thalassemia
    • Hemoglobin C thalassemia
    • Mixed thalassemia
    • Thalassemia with other hemoglobinopathy
    Type 1 Excludes
    • hemoglobin C disease (D58.2)
    • hemoglobin E disease (D58.2)
    • other hemoglobinopathies (D58.2)
    • sickle-cell anemia (D57.-)
    • sickle-cell thalassemia (D57.4)
    D56.8
    )
The following code(s) above D58.2 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D58.2:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D58
    ICD-10-CM Diagnosis Code D58

    Other hereditary hemolytic anemias

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • hemolytic anemia of the newborn (P55.-)
    Other hereditary hemolytic anemias
Approximate Synonyms
  • Abnormal hgb, alpha variant
  • Abnormal hgb, alpha variant homozygous
  • Abnormal hgb, beta variant
  • Abnormal hgb, delta variant
  • Abnormal hgb, delta variant homozygous
  • Abnormal hgb, gamma variant
  • Abnormal hgb, unidentified variant
  • Abnormal presence of hemoglobin, alpha variant
  • Abnormal presence of hemoglobin, alpha variant, homozygous
  • Abnormal presence of hemoglobin, beta variant
  • Abnormal presence of hemoglobin, delta variant
  • Abnormal presence of hemoglobin, delta variant, homozygous
  • Abnormal presence of hemoglobin, gamma variant
  • Abnormal presence of hemoglobin, unidentified variant
  • Hemoglobin c disease
  • Hemoglobin c trait
  • Hemoglobin d disease
  • Hemoglobin d trait
  • Hemoglobin e disease
  • Hemoglobin e trait
  • Hemoglobinopathy
  • Hemoglobinopathy, hereditary
  • Hereditary hemoglobinopathy
Clinical Information
  • A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia. This disorder is caused by a specific mutation in the beta-globin hbb gene, whereby a lysine is substituted for a glutamic acid at the sixth amino acid in the protein.
  • A disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. There may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.
  • A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
  • An inherited disorder characterized by structural alterations of a globin chain within the hemoglobin molecule.
  • Group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
  • Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.
ICD-10-CM D58.2 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc

Convert D58.2 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to D58.2:
  • Type 1 Excludes: D56.5
    , D56.5
    , D56.8
    , D56.8
    , D56.8
    ICD-10-CM Diagnosis Code D56.5

    Hemoglobin E-beta thalassemia

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • beta thalassemia (D56.1)
    • beta thalassemia minor (D56.3)
    • beta thalassemia trait (D56.3)
    • delta-beta thalassemia (D56.2)
    • delta-beta thalassemia trait (D56.3)
    • hemoglobin E disease (D58.2)
    • other hemoglobinopathies (D58.2)
    • sickle-cell beta thalassemia (D57.4-)
    ICD-10-CM Diagnosis Code D56.5

    Hemoglobin E-beta thalassemia

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • beta thalassemia (D56.1)
    • beta thalassemia minor (D56.3)
    • beta thalassemia trait (D56.3)
    • delta-beta thalassemia (D56.2)
    • delta-beta thalassemia trait (D56.3)
    • hemoglobin E disease (D58.2)
    • other hemoglobinopathies (D58.2)
    • sickle-cell beta thalassemia (D57.4-)
    ICD-10-CM Diagnosis Code D56.8

    Other thalassemias

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Dominant thalassemia
    • Hemoglobin C thalassemia
    • Mixed thalassemia
    • Thalassemia with other hemoglobinopathy
    Type 1 Excludes
    • hemoglobin C disease (D58.2)
    • hemoglobin E disease (D58.2)
    • other hemoglobinopathies (D58.2)
    • sickle-cell anemia (D57.-)
    • sickle-cell thalassemia (D57.4)
    ICD-10-CM Diagnosis Code D56.8

    Other thalassemias

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Dominant thalassemia
    • Hemoglobin C thalassemia
    • Mixed thalassemia
    • Thalassemia with other hemoglobinopathy
    Type 1 Excludes
    • hemoglobin C disease (D58.2)
    • hemoglobin E disease (D58.2)
    • other hemoglobinopathies (D58.2)
    • sickle-cell anemia (D57.-)
    • sickle-cell thalassemia (D57.4)
    ICD-10-CM Diagnosis Code D56.8

    Other thalassemias

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Dominant thalassemia
    • Hemoglobin C thalassemia
    • Mixed thalassemia
    • Thalassemia with other hemoglobinopathy
    Type 1 Excludes
    • hemoglobin C disease (D58.2)
    • hemoglobin E disease (D58.2)
    • other hemoglobinopathies (D58.2)
    • sickle-cell anemia (D57.-)
    • sickle-cell thalassemia (D57.4)

Diagnosis Index entries containing back-references to D58.2:
  • Abnormal, abnormality, abnormalities - see also Anomaly
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
    ICD-10-CM Diagnosis Code D64.9

    Anemia, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • congenital P61.4
      ICD-10-CM Diagnosis Code P61.4

      Other congenital anemias, not elsewhere classified

        2016 2017 2018 2019 2020 Billable/Specific Code Code on Newborn Record
      Applicable To
      • Congenital anemia NOS
      • Heinz body D58.2
    • Heinz body, congenital D58.2
  • Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90
    ICD-10-CM Diagnosis Code M19.90

    Unspecified osteoarthritis, unspecified site

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Arthrosis NOS
    • Arthritis NOS
    • Osteoarthritis NOS
    • in (due to)
      • hemoglobinopathy NEC D58.2
  • Arthropathy M12.9
    - see also Arthritis
    ICD-10-CM Diagnosis Code M12.9

    Arthropathy, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • in (due to)
      • hemoglobinopathy NEC D58.2
  • Disease, diseased - see also Syndrome
    • hemoglobin or Hb
      • abnormal (mixed) D58.2
      • C (Hb-C) D58.2
        • with other abnormal hemoglobin NEC D58.2
      • Constant Spring D58.2
      • D D58.2 (Hb-D)
      • E D58.2 (Hb-E)
      • unstable, hemolytic D58.2
    • hemolytic (newborn) P55.9
      ICD-10-CM Diagnosis Code P55.9

      Hemolytic disease of newborn, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code Code on Newborn Record
      • unstable hemoglobin D58.2
  • Heinz body anemia, congenital D58.2
  • Hemoglobin - see also condition
    • Constant Spring D58.2
  • Hemoglobinopathy (mixed) D58.2
  • Osteonecrosis M87.9
    ICD-10-CM Diagnosis Code M87.9

    Osteonecrosis, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Necrosis of bone NOS
    • secondary NEC M87.30
      ICD-10-CM Diagnosis Code M87.30

      Other secondary osteonecrosis, unspecified bone

        2016 2017 2018 2019 2020 Billable/Specific Code
      • due to
        • hemoglobinopathy NEC D58.2
          • carpus D58.2
          • clavicle D58.2
          • femur D58.2
          • fibula D58.2
          • finger D58.2
          • humerus D58.2
          • ilium D58.2
          • ischium D58.2
          • metacarpus D58.2
          • metatarsus D58.2
          • multiple sites D58.2
          • neck D58.2
          • radius D58.2
          • rib D58.2
          • scapula D58.2
          • skull D58.2
          • tarsus D58.2
          • tibia D58.2
          • toe D58.2
          • ulna D58.2
          • vertebra D58.2
  • Trait(s)

ICD-10-CM Codes Adjacent To D58.2
D57.419 …… unspecified
D57.8 Other sickle-cell disorders
D57.80 …… without crisis
D57.81 Other sickle-cell disorders with crisis
D57.811 Other sickle-cell disorders with acute chest syndrome
D57.812 Other sickle-cell disorders with splenic sequestration
D57.819 …… unspecified
D58 Other hereditary hemolytic anemias
D58.0 Hereditary spherocytosis
D58.1 Hereditary elliptocytosis
D58.2 Other hemoglobinopathies
D58.8 Other specified hereditary hemolytic anemias
D58.9 Hereditary hemolytic anemia, unspecified
D59 Acquired hemolytic anemia
D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.