2019/2020

  1. ICD-10-CM Codes
    2. ›
  2. D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    3. ›
  3. D55-D59 Hemolytic anemias
    4. ›
  4. D59- Acquired hemolytic anemia
    5. ›

2020 ICD-10-CM Diagnosis Code D59.1

Other autoimmune hemolytic anemias

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D59.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D59.1 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D59.1 - other international versions of ICD-10 D59.1 may differ.
Applicable To
  • Autoimmune hemolytic disease (cold type) (warm type)
  • Chronic cold hemagglutinin disease
  • Cold agglutinin disease
  • Cold agglutinin hemoglobinuria
  • Cold type (secondary) (symptomatic) hemolytic anemia
  • Warm type (secondary) (symptomatic) hemolytic anemia
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D59.1. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Evans syndrome (
    ICD-10-CM Diagnosis Code D69.41

    Evans syndrome

      2016 2017 2018 2019 2020 Billable/Specific Code
    D69.41
    )
  • hemolytic disease of newborn (
    ICD-10-CM Diagnosis Code P55
    • P55 Hemolytic disease of newborn
      • P55.0 Rh isoimmunization of newborn
      • P55.1 ABO isoimmunization of newborn
      • P55.8 Other hemolytic diseases of newborn
      • P55.9 Hemolytic disease of newborn, unspecified
    P55.-
    )
  • paroxysmal cold hemoglobinuria (
    ICD-10-CM Diagnosis Code D59.6

    Hemoglobinuria due to hemolysis from other external causes

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Hemoglobinuria from exertion
    • March hemoglobinuria
    • Paroxysmal cold hemoglobinuria
    Type 1 Excludes
    • hemoglobinuria NOS (R82.3)
    Use Additional
    • code (Chapter 20) to identify external cause
    D59.6
    )
The following code(s) above D59.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D59.1:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Approximate Synonyms
  • Anemia, autoimmune hemolytic
  • Autoimmune hemolytic anemia
  • Chronic cold agglutinin disease
  • Cold agglutinin disease, chronic
  • Cold autoimmune hemolytic anemia
  • Drug-induced autoimmune hemolytic anemia
  • Hapten type high affinity hemolytic anemia
  • Hapten type low affinity hemolytic anemia
  • Hemolytic anemia associated with rheumatic disorder
  • Hemolytic anemia associated with systemic lupus erythematosus
  • Hemolytic anemia with systemic lupus erythematosus
  • Hemolytic anemia, cold antibody
  • Hemolytic anemia, drug induced autoimmune
  • Hemolytic anemia, due to warm antibody
  • Hemolytic anemia, high affinity hapten
  • Hemolytic anemia, low affinity hapten
  • Hemolytic anemia, rheumatic disease
  • Warm autoimmune hemolytic anemia
ICD-10-CM D59.1 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
  • 809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
  • 810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc

Convert D59.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to D59.1:
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
    ICD-10-CM Diagnosis Code D64.9

    Anemia, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • hemolytic D58.9
      ICD-10-CM Diagnosis Code D58.9

      Hereditary hemolytic anemia, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • acquired D59.9
        ICD-10-CM Diagnosis Code D59.9

        Acquired hemolytic anemia, unspecified

          2016 2017 2018 2019 2020 Billable/Specific Code
        Applicable To
        • Idiopathic hemolytic anemia, chronic
        • autoimmune NEC D59.1
      • acute D59.9
        ICD-10-CM Diagnosis Code D59.9

        Acquired hemolytic anemia, unspecified

          2016 2017 2018 2019 2020 Billable/Specific Code
        Applicable To
        • Idiopathic hemolytic anemia, chronic
        • Lederer's D59.1
      • autoimmune D59.1
      • secondary D59.4
        ICD-10-CM Diagnosis Code D59.4

        Other nonautoimmune hemolytic anemias

          2016 2017 2018 2019 2020 Billable/Specific Code
        Applicable To
        • Mechanical hemolytic anemia
        • Microangiopathic hemolytic anemia
        • Toxic hemolytic anemia
        • autoimmune D59.1
      • symptomatic D59.4
        ICD-10-CM Diagnosis Code D59.4

        Other nonautoimmune hemolytic anemias

          2016 2017 2018 2019 2020 Billable/Specific Code
        Applicable To
        • Mechanical hemolytic anemia
        • Microangiopathic hemolytic anemia
        • Toxic hemolytic anemia
        • autoimmune D59.1
      • cold type D59.1 (secondary) (symptomatic)
      • warm type D59.1 (secondary) (symptomatic)
    • Dyke-Young type D59.1 (secondary) (symptomatic)
    • Lederer's D59.1 (hemolytic)
  • Cold J00
    ICD-10-CM Diagnosis Code J00

    Acute nasopharyngitis [common cold]

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Acute rhinitis
    • Coryza (acute)
    • Infective nasopharyngitis NOS
    • Infective rhinitis
    • Nasal catarrh, acute
    • Nasopharyngitis NOS
    Type 1 Excludes
    Type 2 Excludes
    • agglutinin disease or hemoglobinuria D59.1 (chronic)
    • sensitivity, auto-immune D59.1
  • Disease, diseased - see also Syndrome
    • autoimmune (systemic) M35.9
      ICD-10-CM Diagnosis Code M35.9

      Systemic involvement of connective tissue, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Autoimmune disease (systemic) NOS
      • Collagen (vascular) disease NOS
    • cold
    • hemolytic (newborn) P55.9
      ICD-10-CM Diagnosis Code P55.9

      Hemolytic disease of newborn, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code Code on Newborn Record
      • autoimmune D59.1 (cold type) (warm type)
  • Dyke-Young anemia D59.1 (secondary) (symptomatic)
  • Lederer's anemia D59.1
  • Sensitive, sensitivity - see also Allergy
    • cold, autoimmune D59.1

ICD-10-CM Codes Adjacent To D59.1
D57.812 Other sickle-cell disorders with splenic sequestration
D57.819 …… unspecified
D58 Other hereditary hemolytic anemias
D58.0 Hereditary spherocytosis
D58.1 Hereditary elliptocytosis
D58.2 Other hemoglobinopathies
D58.8 Other specified hereditary hemolytic anemias
D58.9 Hereditary hemolytic anemia, unspecified
D59 Acquired hemolytic anemia
D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes
D59.8 Other acquired hemolytic anemias
D59.9 Acquired hemolytic anemia, unspecified
D60 Acquired pure red cell aplasia [erythroblastopenia]
D60.0 Chronic acquired pure red cell aplasia
D60.1 Transient acquired pure red cell aplasia

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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