2022 ICD-10-CM Diagnosis Code D59.1

Other autoimmune hemolytic anemias

    2016 2017 2018 2019 2020 2021 - Converted to Parent Code 2022 Non-Billable/Non-Specific Code
  • D59.1 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2022 edition of ICD-10-CM D59.1 became effective on October 1, 2021.
  • This is the American ICD-10-CM version of D59.1 - other international versions of ICD-10 D59.1 may differ.
Type 2 Excludes
Type 2 Excludes Help
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (D59.1) and the excluded code together.
  • Evans syndrome (
    ICD-10-CM Diagnosis Code D69.41

    Evans syndrome

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  • hemolytic disease of newborn (
    ICD-10-CM Diagnosis Code P55
    • P55 Hemolytic disease of newborn
      • P55.0 Rh isoimmunization of newborn
      • P55.1 ABO isoimmunization of newborn
      • P55.8 Other hemolytic diseases of newborn
      • P55.9 Hemolytic disease of newborn, unspecified
  • paroxysmal cold hemoglobinuria (
    ICD-10-CM Diagnosis Code D59.6

    Hemoglobinuria due to hemolysis from other external causes

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Hemoglobinuria from exertion
    • March hemoglobinuria
    • Paroxysmal cold hemoglobinuria
    Type 1 Excludes
    • hemoglobinuria NOS (R82.3)
    Use Additional
    • code (Chapter 20) to identify external cause
The following code(s) above D59.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D59.1:
  • D50-D89
    2022 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Approximate Synonyms
  • Anemia, autoimmune hemolytic
  • Autoimmune hemolytic anemia
  • Chronic cold agglutinin disease
  • Cold agglutinin disease, chronic
  • Cold autoimmune hemolytic anemia
  • Drug-induced autoimmune hemolytic anemia
  • Hapten type high affinity hemolytic anemia
  • Hapten type low affinity hemolytic anemia
  • Hemolytic anemia associated with rheumatic disorder
  • Hemolytic anemia associated with systemic lupus erythematosus
  • Hemolytic anemia with systemic lupus erythematosus
  • Hemolytic anemia, cold antibody
  • Hemolytic anemia, drug induced autoimmune
  • Hemolytic anemia, due to warm antibody
  • Hemolytic anemia, high affinity hapten
  • Hemolytic anemia, low affinity hapten
  • Hemolytic anemia, rheumatic disease
  • Warm autoimmune hemolytic anemia
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): Deleted code
  • 2021 (effective 10/1/2020): New code
  • 2022 (effective 10/1/2021): No change
ICD-10-CM Codes Adjacent To D59.1
D57.818 …… with other specified complication
D57.819 …… unspecified
D58 Other hereditary hemolytic anemias
D58.0 Hereditary spherocytosis
D58.1 Hereditary elliptocytosis
D58.2 Other hemoglobinopathies
D58.8 Other specified hereditary hemolytic anemias
D58.9 Hereditary hemolytic anemia, unspecified
D59 Acquired hemolytic anemia
D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
D59.10 Autoimmune hemolytic anemia, unspecified
D59.11 Warm autoimmune hemolytic anemia
D59.12 Cold autoimmune hemolytic anemia
D59.13 Mixed type autoimmune hemolytic anemia
D59.19 Other autoimmune hemolytic anemia
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.