2021 ICD-10-CM Diagnosis Code D59.12

Cold autoimmune hemolytic anemia

    2021 - New Code Billable/Specific Code
  • D59.12 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • ICD-10-CM D59.12 is a new 2021 ICD-10-CM code that became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D59.12 - other international versions of ICD-10 D59.12 may differ.
Applicable To
  • Chronic cold hemagglutinin disease
  • Cold agglutinin disease
  • Cold agglutinin hemoglobinuria
  • Cold type (primary) (secondary) (symptomatic) autoimmune hemolytic anemia
  • Cold type autoimmune hemolytic disease
The following code(s) above D59.12 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D59.12:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D59.1
    ICD-10-CM Diagnosis Code D59.1

    Other autoimmune hemolytic anemias

      2016 2017 2018 2019 2020 2021 - Converted to Parent Code Non-Billable/Non-Specific Code
    Type 2 Excludes
    • Evans syndrome (D69.41)
    • hemolytic disease of newborn (P55.-)
    • paroxysmal cold hemoglobinuria (D59.6)
    Other autoimmune hemolytic anemias
ICD-10-CM D59.12 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
  • 809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
  • 810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc
Code History
  • 2021 (effective 10/1/2020): New code

Diagnosis Index entries containing back-references to D59.12:
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
    ICD-10-CM Diagnosis Code D64.9

    Anemia, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    • hemolytic D58.9
      ICD-10-CM Diagnosis Code D58.9

      Hereditary hemolytic anemia, unspecified

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      • autoimmune D59.10
        ICD-10-CM Diagnosis Code D59.10

        Autoimmune hemolytic anemia, unspecified

          2021 - New Code Billable/Specific Code
        • cold D59.12
      • primary
      • secondary D59.4
        ICD-10-CM Diagnosis Code D59.4

        Other nonautoimmune hemolytic anemias

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Mechanical hemolytic anemia
        • Microangiopathic hemolytic anemia
        • Toxic hemolytic anemia
      • symptomatic D59.4
        ICD-10-CM Diagnosis Code D59.4

        Other nonautoimmune hemolytic anemias

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Applicable To
        • Mechanical hemolytic anemia
        • Microangiopathic hemolytic anemia
        • Toxic hemolytic anemia
      • cold type D59.12 (primary) (secondary) (symptomatic)
  • Cold J00
    ICD-10-CM Diagnosis Code J00

    Acute nasopharyngitis [common cold]

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Acute rhinitis
    • Coryza (acute)
    • Infective nasopharyngitis NOS
    • Infective rhinitis
    • Nasal catarrh, acute
    • Nasopharyngitis NOS
    Type 1 Excludes
    Type 2 Excludes
    • agglutinin disease or hemoglobinuria D59.12 (chronic)
    • sensitivity, auto-immune D59.12
  • Disease, diseased - see also Syndrome
    • autoimmune (systemic) M35.9
      ICD-10-CM Diagnosis Code M35.9

      Systemic involvement of connective tissue, unspecified

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • Autoimmune disease (systemic) NOS
      • Collagen (vascular) disease NOS
      • hemolytic D59.10
        ICD-10-CM Diagnosis Code D59.10

        Autoimmune hemolytic anemia, unspecified

          2021 - New Code Billable/Specific Code
        • cold type D59.12 (primary) (secondary) (symptomatic)
    • cold
    • hemolytic (newborn) P55.9
      ICD-10-CM Diagnosis Code P55.9

      Hemolytic disease of newborn, unspecified

        2016 2017 2018 2019 2020 2021 Billable/Specific Code Code on Newborn Record
      • autoimmune D59.10
        ICD-10-CM Diagnosis Code D59.10

        Autoimmune hemolytic anemia, unspecified

          2021 - New Code Billable/Specific Code
        • cold type D59.12 (primary) (secondary) (symptomatic)
  • Hemoglobinuria R82.3
    ICD-10-CM Diagnosis Code R82.3

    Hemoglobinuria

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Type 1 Excludes
    • hemoglobinuria due to hemolysis from external causes NEC (D59.6)
    • hemoglobinuria due to paroxysmal nocturnal [Marchiafava-Micheli] (D59.5)
    • cold (paroxysmal) (with Raynaud's syndrome) D59.6
      ICD-10-CM Diagnosis Code D59.6

      Hemoglobinuria due to hemolysis from other external causes

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • Hemoglobinuria from exertion
      • March hemoglobinuria
      • Paroxysmal cold hemoglobinuria
      Type 1 Excludes
      • hemoglobinuria NOS (R82.3)
      Use Additional
      • code (Chapter 20) to identify external cause
      • agglutinin D59.12
  • Sensitive, sensitivity - see also Allergy
    • cold, autoimmune D59.12

ICD-10-CM Codes Adjacent To D59.12
D58.0 Hereditary spherocytosis
D58.1 Hereditary elliptocytosis
D58.2 Other hemoglobinopathies
D58.8 Other specified hereditary hemolytic anemias
D58.9 Hereditary hemolytic anemia, unspecified
D59 Acquired hemolytic anemia
D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
D59.10 Autoimmune hemolytic anemia, unspecified
D59.11 Warm autoimmune hemolytic anemia
D59.12 Cold autoimmune hemolytic anemia
D59.13 Mixed type autoimmune hemolytic anemia
D59.19 Other autoimmune hemolytic anemia
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes
D59.8 Other acquired hemolytic anemias
D59.9 Acquired hemolytic anemia, unspecified
D60 Acquired pure red cell aplasia [erythroblastopenia]

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.