2020 ICD-10-CM Diagnosis Code D59.2

Drug-induced nonautoimmune hemolytic anemia

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D59.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D59.2 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D59.2 - other international versions of ICD-10 D59.2 may differ.
Applicable To
  • Drug-induced enzyme deficiency anemia
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code for adverse effect, if applicable, to identify drug (T36-T50
    ICD-10-CM Range T36-T50

    Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

    Code First
    • , for adverse effects, the nature of the adverse effect, such as:
    • adverse effect NOS (T88.7)
    • aspirin gastritis (K29.-)
    • blood disorders (D56-D76)
    • contact dermatitis (L23-L25)
    • dermatitis due to substances taken internally (L27.-)
    • nephropathy (N14.0-N14.2)
    Includes
    • adverse effect of correct substance properly administered
    • poisoning by overdose of substance
    • poisoning by wrong substance given or taken in error
    • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
    Note
    • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
    Type 1 Excludes
    • toxic reaction to local anesthesia in pregnancy (O29.3-)
    Type 2 Excludes
    • abuse and dependence of psychoactive substances (F10-F19)
    • abuse of non-dependence-producing substances (F55.-)
    • drug reaction and poisoning affecting newborn (P00-P96)
    • pathological drug intoxication (inebriation) (F10-F19)
    Use Additional
    • code(s) to specify:
    • manifestations of poisoning
    • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
    • underdosing of medication regimen (Z91.12-, Z91.13-)
    • T36 Poisoning by, adverse effect of and unde...
    • T37 Poisoning by, adverse effect of and unde...
    • T38 Poisoning by, adverse effect of and unde...
    • T39 Poisoning by, adverse effect of and unde...
    • T40 Poisoning by, adverse effect of and unde...
    • T41 Poisoning by, adverse effect of and unde...
    • T42 Poisoning by, adverse effect of and unde...
    • T43 Poisoning by, adverse effect of and unde...
    • T44 Poisoning by, adverse effect of and unde...
    • T45 Poisoning by, adverse effect of and unde...
    • T46 Poisoning by, adverse effect of and unde...
    • T47 Poisoning by, adverse effect of and unde...
    • T48 Poisoning by, adverse effect of and unde...
    • T49 Poisoning by, adverse effect of and unde...
    • T50 Poisoning by, adverse effect of and unde...
    with fifth or sixth character 5)
The following code(s) above D59.2 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D59.2:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Approximate Synonyms
  • Anemia, hemolytic, drug induced nonautoimmune
  • Non-autoimmune hemolytic anemia due to drug
ICD-10-CM D59.2 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
  • 809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
  • 810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc

Convert D59.2 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to D59.2:
  • Type 1 Excludes: D55
    ICD-10-CM Diagnosis Code D55

    Anemia due to enzyme disorders

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • drug-induced enzyme deficiency anemia (D59.2)

Diagnosis Index entries containing back-references to D59.2:
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
    ICD-10-CM Diagnosis Code D64.9

    Anemia, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • deficiency D53.9
      ICD-10-CM Diagnosis Code D53.9

      Nutritional anemia, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Simple chronic anemia
      Type 1 Excludes
      • enzyme D55.9
        ICD-10-CM Diagnosis Code D55.9

        Anemia due to enzyme disorder, unspecified

          2016 2017 2018 2019 2020 Billable/Specific Code
        • drug-induced D59.2 (hemolytic)
    • hemolytic D58.9
      ICD-10-CM Diagnosis Code D58.9

      Hereditary hemolytic anemia, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • due to
        • drugs (nonautoimmune) D59.2
        • enzyme disorder D55.9
          ICD-10-CM Diagnosis Code D55.9

          Anemia due to enzyme disorder, unspecified

            2016 2017 2018 2019 2020 Billable/Specific Code
          • drug-induced D59.2
      • nonautoimmune D59.4
        ICD-10-CM Diagnosis Code D59.4

        Other nonautoimmune hemolytic anemias

          2016 2017 2018 2019 2020 Billable/Specific Code
        Applicable To
        • Mechanical hemolytic anemia
        • Microangiopathic hemolytic anemia
        • Toxic hemolytic anemia
        • drug-induced D59.2
    • enzyme-deficiency, drug-induced D59.2
  • Disease, diseased - see also Syndrome
    • nonautoimmune hemolytic D59.4
      ICD-10-CM Diagnosis Code D59.4

      Other nonautoimmune hemolytic anemias

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Mechanical hemolytic anemia
      • Microangiopathic hemolytic anemia
      • Toxic hemolytic anemia
      • drug-induced D59.2
  • Nonautoimmune hemolytic anemia D59.4
    ICD-10-CM Diagnosis Code D59.4

    Other nonautoimmune hemolytic anemias

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Mechanical hemolytic anemia
    • Microangiopathic hemolytic anemia
    • Toxic hemolytic anemia
    • drug-induced D59.2

ICD-10-CM Codes Adjacent To D59.2
D57.819 …… unspecified
D58 Other hereditary hemolytic anemias
D58.0 Hereditary spherocytosis
D58.1 Hereditary elliptocytosis
D58.2 Other hemoglobinopathies
D58.8 Other specified hereditary hemolytic anemias
D58.9 Hereditary hemolytic anemia, unspecified
D59 Acquired hemolytic anemia
D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes
D59.8 Other acquired hemolytic anemias
D59.9 Acquired hemolytic anemia, unspecified
D60 Acquired pure red cell aplasia [erythroblastopenia]
D60.0 Chronic acquired pure red cell aplasia
D60.1 Transient acquired pure red cell aplasia
D60.8 Other acquired pure red cell aplasias

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.