ICD-10-CM Codes
D50-D89
D55-D59
D59-
2023 ICD-10-CM Diagnosis Code D59.2

2023 ICD-10-CM Diagnosis Code D59.2

Drug-induced nonautoimmune hemolytic anemia

2016

2017

2018

2019

2020

2021

2022

2023

Billable/Specific Code

D59.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2023 edition of ICD-10-CM D59.2 became effective on October 1, 2022.
This is the American ICD-10-CM version of D59.2 - other international versions of ICD-10 D59.2 may differ.

Applicable To

Drug-induced enzyme deficiency anemia

Use Additional

Use Additional Help

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.

code for adverse effect, if applicable, to identify drug (T36-T50
ICD-10-CM Range T36-T50
Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
Code First
- , for adverse effects, the nature of the adverse effect, such as:
- adverse effect NOS (T88.7)
- aspirin gastritis (K29.-)
- blood disorders (D56-D76)
- contact dermatitis (L23-L25)
- dermatitis due to substances taken internally (L27.-)
- nephropathy (N14.0-N14.2)
Includes
- adverse effect of correct substance properly administered
- poisoning by overdose of substance
- poisoning by wrong substance given or taken in error
- underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Note
- The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
Type 1 Excludes
- toxic reaction to local anesthesia in pregnancy (O29.3-)
Type 2 Excludes
- abuse and dependence of psychoactive substances (F10-F19)
- abuse of non-dependence-producing substances (F55.-)
- immunodeficiency due to drugs (D84.821)
- drug reaction and poisoning affecting newborn (P00-P96)
- pathological drug intoxication (inebriation) (F10-F19)
Use Additional
- code(s) to specify:
- manifestations of poisoning
- underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
- underdosing of medication regimen (Z91.12-, Z91.13-)
- T36 Poisoning by, adverse effect of and unde...
- T37 Poisoning by, adverse effect of and unde...
- T38 Poisoning by, adverse effect of and unde...
- T39 Poisoning by, adverse effect of and unde...
- T40 Poisoning by, adverse effect of and unde...
- T41 Poisoning by, adverse effect of and unde...
- T42 Poisoning by, adverse effect of and unde...
- T43 Poisoning by, adverse effect of and unde...
- T44 Poisoning by, adverse effect of and unde...
- T45 Poisoning by, adverse effect of and unde...
- T46 Poisoning by, adverse effect of and unde...
- T47 Poisoning by, adverse effect of and unde...
- T48 Poisoning by, adverse effect of and unde...
- T49 Poisoning by, adverse effect of and unde...
- T50 Poisoning by, adverse effect of and unde...
with fifth or sixth character 5)

The following code(s) above D59.2 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D59.2:

D50-D89
2023 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Approximate Synonyms

Anemia, hemolytic, drug induced nonautoimmune
Non-autoimmune hemolytic anemia due to drug

ICD-10-CM D59.2 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):

791 Prematurity with major problems
793 Full term neonate with major problems
808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc

Convert D59.2 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change
2023 (effective 10/1/2022): No change

Code annotations containing back-references to D59.2:

Type 1 Excludes: D55

ICD-10-CM Diagnosis Code D55
Anemia due to enzyme disorders
Type 1 Excludes
- drug-induced enzyme deficiency anemia (D59.2)

Diagnosis Index entries containing back-references to D59.2:

Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
ICD-10-CM Diagnosis Code D64.9
Anemia, unspecified
- deficiency D53.9
  ICD-10-CM Diagnosis Code D53.9
  Nutritional anemia, unspecified
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Applicable To
  Simple chronic anemia
  Type 1 Excludes
  anemia NOS (D64.9)
  - enzyme D55.9
    ICD-10-CM Diagnosis Code D55.9
    Anemia due to enzyme disorder, unspecified
    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    - drug-induced D59.2 (hemolytic)
- hemolytic D58.9
  ICD-10-CM Diagnosis Code D58.9
  Hereditary hemolytic anemia, unspecified
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - due to
    - drugs (nonautoimmune) D59.2
    - enzyme disorder D55.9
      ICD-10-CM Diagnosis Code D55.9
      Anemia due to enzyme disorder, unspecified
      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
      - drug-induced D59.2
  - nonautoimmune D59.4
    ICD-10-CM Diagnosis Code D59.4
    Other nonautoimmune hemolytic anemias
    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Applicable To
    Mechanical hemolytic anemia
    Microangiopathic hemolytic anemia
    Toxic hemolytic anemia
    - drug-induced D59.2
- enzyme-deficiency, drug-induced D59.2
Disease, diseased - see also Syndrome
- nonautoimmune hemolytic D59.4
  ICD-10-CM Diagnosis Code D59.4
  Other nonautoimmune hemolytic anemias
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Applicable To
  Mechanical hemolytic anemia
  Microangiopathic hemolytic anemia
  Toxic hemolytic anemia
  - drug-induced D59.2
Nonautoimmune hemolytic anemia D59.4
ICD-10-CM Diagnosis Code D59.4
Other nonautoimmune hemolytic anemias
Applicable To
Mechanical hemolytic anemia
Microangiopathic hemolytic anemia
Toxic hemolytic anemia
- drug-induced D59.2

ICD-10-CM Codes Adjacent To D59.2

D58.8 Other specified hereditary hemolytic anemias

D58.9 Hereditary hemolytic anemia, unspecified

D59 Acquired hemolytic anemia

D59.0 Drug-induced autoimmune hemolytic anemia

D59.1 Other autoimmune hemolytic anemias

D59.10 Autoimmune hemolytic anemia, unspecified

D59.11 Warm autoimmune hemolytic anemia

D59.12 Cold autoimmune hemolytic anemia

D59.13 Mixed type autoimmune hemolytic anemia

D59.19 Other autoimmune hemolytic anemia

D59.2 Drug-induced nonautoimmune hemolytic anemia

D59.3 Hemolytic-uremic syndrome

D59.30 …… unspecified

D59.31 Infection-associated hemolytic-uremic syndrome

D59.32 Hereditary hemolytic-uremic syndrome

D59.39 Other hemolytic-uremic syndrome

D59.4 Other nonautoimmune hemolytic anemias

D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]

D59.6 Hemoglobinuria due to hemolysis from other external causes

D59.8 Other acquired hemolytic anemias

D59.9 Acquired hemolytic anemia, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2023 ICD-10-CM Diagnosis Code D59.2

Drug-induced nonautoimmune hemolytic anemia

Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Anemia due to enzyme disorders

Anemia, unspecified

Nutritional anemia, unspecified

Anemia due to enzyme disorder, unspecified

Hereditary hemolytic anemia, unspecified

Anemia due to enzyme disorder, unspecified

Other nonautoimmune hemolytic anemias

Other nonautoimmune hemolytic anemias

Other nonautoimmune hemolytic anemias