2023 ICD-10-CM Diagnosis Code D59.3

Hemolytic-uremic syndrome

    2016 2017 2018 2019 2020 2021 2022 2023 - Converted to Parent Code Non-Billable/Non-Specific Code
  • D59.3 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • ICD-10-CM D59.3 is a new 2023 ICD-10-CM code that became effective on October 1, 2022.
  • This is the American ICD-10-CM version of D59.3 - other international versions of ICD-10 D59.3 may differ.
Code Also
Code Also Help
A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.
  • , if applicable, any associated:
  • acute kidney failure (
    ICD-10-CM Diagnosis Code N17
    • N17 Acute kidney failure
      • N17.0 Acute kidney failure with tubular necrosis
      • N17.1 Acute kidney failure with acute cortical necr...
      • N17.2 Acute kidney failure with medullary necrosis
      • N17.8 Other acute kidney failure
      • N17.9 Acute kidney failure, unspecified
  • chronic kidney disease (
    ICD-10-CM Diagnosis Code N18
    • N18 Chronic kidney disease (CKD)
      • N18.1 Chronic kidney disease, stage 1
      • N18.2 Chronic kidney disease, stage 2 (mild)
      • N18.3 Chronic kidney disease, stage 3 (moderate)
        • N18.30 Chronic kidney disease, stage 3 unspecified
        • N18.31 Chronic kidney disease, stage 3a
        • N18.32 Chronic kidney disease, stage 3b
      • N18.4 Chronic kidney disease, stage 4 (severe)
      • N18.5 Chronic kidney disease, stage 5
      • N18.6 End stage renal disease
      • N18.9 Chronic kidney disease, unspecified
The following code(s) above D59.3 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D59.3:
  • D50-D89
    2023 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Approximate Synonyms
  • Hemolytic uremic syndrome
Clinical Information
  • A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.
  • A form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.
  • A syndrome that is associated with microvascular diseases of the kidney, such as renal cortical necrosis. It is characterized by hemolytic anemia (anemia, hemolytic); thrombocytopenia; and acute renal failure.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): Deleted code
  • 2023 (effective 10/1/2022): New code
Code annotations containing back-references to D59.3:
  • Type 1 Excludes: N08
    , D69.1
    ICD-10-CM Diagnosis Code N08

    Glomerular disorders in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code Manifestation Code
    Applicable To
    • Glomerulonephritis
    • Nephritis
    • Nephropathy
    Code First
    Type 1 Excludes
    • glomerulonephritis, nephritis and nephropathy (in):
    • antiglomerular basement membrane disease (M31.0)
    • diabetes (E08-E13 with .21)
    • gonococcal (A54.21)
    • Goodpasture's syndrome (M31.0)
    • hemolytic-uremic syndrome (D59.3-)
    • lupus (M32.14)
    • mumps (B26.83)
    • syphilis (A52.75)
    • systemic lupus erythematosus (M32.14)
    • Wegener's granulomatosis (M31.31)
    • pyelonephritis in diseases classified elsewhere (N16)
    • renal tubulo-interstitial disorders classified elsewhere (N16)
    ICD-10-CM Diagnosis Code D69.1

    Qualitative platelet defects

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Applicable To
    • Bernard-Soulier [giant platelet] syndrome
    • Glanzmann's disease
    • Grey platelet syndrome
    • Thromboasthenia (hemorrhagic) (hereditary)
    • Thrombocytopathy
    Type 1 Excludes
    • hemolytic-uremic syndrome (D59.3-)
    Type 2 Excludes
    • von Willebrand disease (D68.0-)
  • Use Additional: M31.11
    ICD-10-CM Diagnosis Code M31.11

    Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]

      2022 - New Code 2023 Billable/Specific Code
    Applicable To
    • Transplant-associated thrombotic microangiopathy [TA-TMA]
    Code First
    • if applicable:
    • complications of bone marrow transplant (T86.0-)
    • complications of stem cell transplant (T86.5)
    Use Additional
    • code to identify specific organ dysfunction, such as:
    • acute kidney failure (N17.-)
    • acute respiratory distress syndrome (J80)
    • capillary leak syndrome (I78.8)
    • diffuse alveolar hemorrhage (R04.89)
    • encephalopathy (metabolic) (septic) (G93.41)
    • fluid overload, unspecified (E87.70)
    • graft versus host disease (D89.81-)
    • hemolytic uremic syndrome (D59.3-)
    • hepatic failure (K72.-)
    • hepatic veno-occlusive disease (K76.5)
    • idiopathic interstitial pneumonia (J84.11-)
    • sinusoidal obstruction syndrome (K76.5)
ICD-10-CM Codes Adjacent To D59.3
D58.9 Hereditary hemolytic anemia, unspecified
D59 Acquired hemolytic anemia
D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
D59.10 Autoimmune hemolytic anemia, unspecified
D59.11 Warm autoimmune hemolytic anemia
D59.12 Cold autoimmune hemolytic anemia
D59.13 Mixed type autoimmune hemolytic anemia
D59.19 Other autoimmune hemolytic anemia
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.30 …… unspecified
D59.31 Infection-associated hemolytic-uremic syndrome
D59.32 Hereditary hemolytic-uremic syndrome
D59.39 Other hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes
D59.8 Other acquired hemolytic anemias
D59.9 Acquired hemolytic anemia, unspecified
D60 Acquired pure red cell aplasia [erythroblastopenia]

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.