2020 ICD-10-CM Diagnosis Code D59.3

Hemolytic-uremic syndrome

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D59.3 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D59.3 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D59.3 - other international versions of ICD-10 D59.3 may differ.
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Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code to identify associated:
  • E. coli infection (
    ICD-10-CM Diagnosis Code B96.2

    Escherichia coli [E. coli ] as the cause of diseases classified elsewhere

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    B96.2-
    )
  • Pneumococcal pneumonia (
    ICD-10-CM Diagnosis Code J13

    Pneumonia due to Streptococcus pneumoniae

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Bronchopneumonia due to S. pneumoniae
    Code First
    Code Also
    • associated abscess, if applicable (J85.1)
    Type 1 Excludes
    • congenital pneumonia due to S. pneumoniae (P23.6)
    • lobar pneumonia, unspecified organism (J18.1)
    • pneumonia due to other streptococci (J15.3-J15.4)
    J13
    )
  • Shigella dysenteriae (
    ICD-10-CM Diagnosis Code A03.9

    Shigellosis, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Bacillary dysentery NOS
    A03.9
    )
The following code(s) above D59.3 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D59.3:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Approximate Synonyms
  • Hemolytic uremic syndrome
Clinical Information
  • A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.
  • A form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.
  • A syndrome that is associated with microvascular diseases of the kidney, such as renal cortical necrosis. It is characterized by hemolytic anemia (anemia, hemolytic); thrombocytopenia; and acute renal failure.
ICD-10-CM D59.3 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc

Convert D59.3 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to D59.3:
  • Type 1 Excludes: N08
    ICD-10-CM Diagnosis Code N08

    Glomerular disorders in diseases classified elsewhere

      2016 2017 2018 2019 2020 Billable/Specific Code Manifestation Code
    Applicable To
    • Glomerulonephritis
    • Nephritis
    • Nephropathy
    Code First
    Type 1 Excludes
    • glomerulonephritis, nephritis and nephropathy (in):
    • antiglomerular basement membrane disease (M31.0)
    • diabetes (E08-E13 with .21)
    • gonococcal (A54.21)
    • Goodpasture's syndrome (M31.0)
    • hemolytic-uremic syndrome (D59.3)
    • lupus (M32.14)
    • mumps (B26.83)
    • syphilis (A52.75)
    • systemic lupus erythematosus (M32.14)
    • Wegener's granulomatosis (M31.31)
    • pyelonephritis in diseases classified elsewhere (N16)
    • renal tubulo-interstitial disorders classified elsewhere (N16)

Diagnosis Index entries containing back-references to D59.3:
  • Disorder (of) - see also Disease
    • glomerular (in) N05.9
      ICD-10-CM Diagnosis Code N05.9

      Unspecified nephritic syndrome with unspecified morphologic changes

        2016 2017 2018 2019 2020 Billable/Specific Code
      • hemolytic-uremic syndrome D59.3
  • Glomerulonephritis N05.9
    - see also Nephritis
    ICD-10-CM Diagnosis Code N05.9

    Unspecified nephritic syndrome with unspecified morphologic changes

      2016 2017 2018 2019 2020 Billable/Specific Code
    • in (due to)
      • hemolytic-uremic syndrome D59.3
  • Syndrome - see also Disease
    • hemolytic-uremic D59.3

ICD-10-CM Codes Adjacent To D59.3
D58 Other hereditary hemolytic anemias
D58.0 Hereditary spherocytosis
D58.1 Hereditary elliptocytosis
D58.2 Other hemoglobinopathies
D58.8 Other specified hereditary hemolytic anemias
D58.9 Hereditary hemolytic anemia, unspecified
D59 Acquired hemolytic anemia
D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes
D59.8 Other acquired hemolytic anemias
D59.9 Acquired hemolytic anemia, unspecified
D60 Acquired pure red cell aplasia [erythroblastopenia]
D60.0 Chronic acquired pure red cell aplasia
D60.1 Transient acquired pure red cell aplasia
D60.8 Other acquired pure red cell aplasias
D60.9 Acquired pure red cell aplasia, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.