2023 ICD-10-CM Diagnosis Code D59.31

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Infection-associated hemolytic-uremic syndrome

    2023 - New Code Billable/Specific Code
  • D59.31 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • ICD-10-CM D59.31 is a new 2023 ICD-10-CM code that became effective on October 1, 2022.
  • This is the American ICD-10-CM version of D59.31 - other international versions of ICD-10 D59.31 may differ.
Applicable To
  • Shiga toxin-producing E. coli [STEC] related hemolytic uremic syndrome
  • Typical hemolytic uremic syndrome
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Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code to identify associated infection, such as :
  • E. coli infection (
    ICD-10-CM Diagnosis Code B96.2

    Escherichia coli [E. coli ] as the cause of diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    B96.2-
    )
  • Human immunodeficiency virus [HIV] disease (
    ICD-10-CM Diagnosis Code B20

    Human immunodeficiency virus [HIV] disease

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Code First
    • Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
    Includes
    • acquired immune deficiency syndrome [AIDS]
    • AIDS-related complex [ARC]
    • HIV infection, symptomatic
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
    • exposure to HIV virus (Z20.6)
    • inconclusive serologic evidence of HIV (R75)
    Use Additional
    • code(s) to identify all manifestations of HIV infection
    B20
    )
  • Pneumococcal meningitis (
    ICD-10-CM Diagnosis Code G00.1

    Pneumococcal meningitis

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Applicable To
    • Meningtitis due to Streptococcal pneumoniae
    G00.1
    )
  • Pneumococcal pneumonia (
    ICD-10-CM Diagnosis Code J13

    Pneumonia due to Streptococcus pneumoniae

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Applicable To
    • Bronchopneumonia due to S. pneumoniae
    Code First
    Code Also
    • associated abscess, if applicable (J85.1)
    Type 1 Excludes
    • congenital pneumonia due to S. pneumoniae (P23.6)
    • lobar pneumonia, unspecified organism (J18.1)
    • pneumonia due to other streptococci (J15.3-J15.4)
    J13
    )
  • Sepsis due to Streptococcus pneumoniae (
    ICD-10-CM Diagnosis Code A40.3

    Sepsis due to Streptococcus pneumoniae

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Applicable To
    • Pneumococcal sepsis
    A40.3
    )
  • Shigella dysenteriae (
    ICD-10-CM Diagnosis Code A03.9

    Shigellosis, unspecified

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Applicable To
    • Bacillary dysentery NOS
    A03.9
    )
  • Streptococcus pneumoniae as the cause of diseases classified elsewhere (
    ICD-10-CM Diagnosis Code B95.3

    Streptococcus pneumoniae as the cause of diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    B95.3
    )
The following code(s) above D59.31 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D59.31:
  • D50-D89
    2023 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D59.3
    ICD-10-CM Diagnosis Code D59.3

    Hemolytic-uremic syndrome

      2016 2017 2018 2019 2020 2021 2022 2023 - Converted to Parent Code Non-Billable/Non-Specific Code
    Code Also
    • , if applicable, any associated:
    • acute kidney failure (N17.-)
    • chronic kidney disease (N18.-)
    Hemolytic-uremic syndrome
ICD-10-CM D59.31 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc
Code History
  • 2023 (effective 10/1/2022): New code

Diagnosis Index entries containing back-references to D59.31:
  • Syndrome - see also Disease
    • hemolytic-uremic D59.30
      ICD-10-CM Diagnosis Code D59.30

      Hemolytic-uremic syndrome, unspecified

        2023 - New Code Billable/Specific Code
      Applicable To
      • Hemolytic-uremic syndrome NOS
      • atypical D59.39
        ICD-10-CM Diagnosis Code D59.39

        Other hemolytic-uremic syndrome

          2023 - New Code Billable/Specific Code
        Applicable To
        • Atypical (nongenetic) hemolytic uremic syndrome
        • Secondary hemolytic-uremic syndrome
        Code First
        • , if applicable, any associated:
        • COVID-19 (U07.1)
        • complications of kidney transplant (T86.1-)
        • complications of heart transplant (T86.2-)
        • complications of liver transplant (T86.4-)
        Code Also
        • , if applicable, any associated condition, such as:
        • hypertensive emergency (I16.1)
        • malignant neoplasm (C00-C96)
        • systemic lupus erythematosus (M32.-)
        Use Additional
        • code, if applicable, for adverse effect to identify drug (T36-T50 with fifth or sixth character 5)
        • infection-associated D59.31
      • infection-associated D59.31
      • Shiga toxin-producing E. coli [STEC] related D59.31
      • typical D59.31

ICD-10-CM Codes Adjacent To D59.31
D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
D59.10 Autoimmune hemolytic anemia, unspecified
D59.11 Warm autoimmune hemolytic anemia
D59.12 Cold autoimmune hemolytic anemia
D59.13 Mixed type autoimmune hemolytic anemia
D59.19 Other autoimmune hemolytic anemia
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.30 …… unspecified
D59.31 Infection-associated hemolytic-uremic syndrome
D59.32 Hereditary hemolytic-uremic syndrome
D59.39 Other hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes
D59.8 Other acquired hemolytic anemias
D59.9 Acquired hemolytic anemia, unspecified
D60 Acquired pure red cell aplasia [erythroblastopenia]
D60.0 Chronic acquired pure red cell aplasia
D60.1 Transient acquired pure red cell aplasia

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.