2023 ICD-10-CM Diagnosis Code D59.39

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Other hemolytic-uremic syndrome

    2023 - New Code Billable/Specific Code
  • D59.39 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • ICD-10-CM D59.39 is a new 2023 ICD-10-CM code that became effective on October 1, 2022.
  • This is the American ICD-10-CM version of D59.39 - other international versions of ICD-10 D59.39 may differ.
Applicable To
  • Atypical (nongenetic) hemolytic uremic syndrome
  • Secondary hemolytic-uremic syndrome
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code, if applicable, for adverse effect to identify drug (T36-T50
    ICD-10-CM Range T36-T50

    Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

    Code First
    • , for adverse effects, the nature of the adverse effect, such as:
    • adverse effect NOS (T88.7)
    • aspirin gastritis (K29.-)
    • blood disorders (D56-D76)
    • contact dermatitis (L23-L25)
    • dermatitis due to substances taken internally (L27.-)
    • nephropathy (N14.0-N14.2)
    Includes
    • adverse effect of correct substance properly administered
    • poisoning by overdose of substance
    • poisoning by wrong substance given or taken in error
    • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
    Note
    • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
    Type 1 Excludes
    • toxic reaction to local anesthesia in pregnancy (O29.3-)
    Type 2 Excludes
    • abuse and dependence of psychoactive substances (F10-F19)
    • abuse of non-dependence-producing substances (F55.-)
    • immunodeficiency due to drugs (D84.821)
    • drug reaction and poisoning affecting newborn (P00-P96)
    • pathological drug intoxication (inebriation) (F10-F19)
    Use Additional
    • code(s) to specify:
    • manifestations of poisoning
    • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
    • underdosing of medication regimen (Z91.12-, Z91.13-)
    • T36 Poisoning by, adverse effect of and unde...
    • T37 Poisoning by, adverse effect of and unde...
    • T38 Poisoning by, adverse effect of and unde...
    • T39 Poisoning by, adverse effect of and unde...
    • T40 Poisoning by, adverse effect of and unde...
    • T41 Poisoning by, adverse effect of and unde...
    • T42 Poisoning by, adverse effect of and unde...
    • T43 Poisoning by, adverse effect of and unde...
    • T44 Poisoning by, adverse effect of and unde...
    • T45 Poisoning by, adverse effect of and unde...
    • T46 Poisoning by, adverse effect of and unde...
    • T47 Poisoning by, adverse effect of and unde...
    • T48 Poisoning by, adverse effect of and unde...
    • T49 Poisoning by, adverse effect of and unde...
    • T50 Poisoning by, adverse effect of and unde...
    with fifth or sixth character 5)
Code First
Code First Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • , if applicable, any associated:
  • COVID-19 (
    ICD-10-CM Diagnosis Code U07.1

    COVID-19

      2021 - New Code 2022 2023 Billable/Specific Code
    Type 1 Excludes
    • coronavirus infection, unspecified (B34.2)
    • coronavirus as the cause of diseases classified elsewhere (B97.2-)
    • pneumonia due to SARS-associated coronavirus (J12.81)
    Use Additional
    • code to identify pneumonia or other manifestations
    U07.1
    )
  • complications of kidney transplant (
    ICD-10-CM Diagnosis Code T86.1

    Complications of kidney transplant

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    T86.1-
    )
  • complications of heart transplant (
    ICD-10-CM Diagnosis Code T86.2

    Complications of heart transplant

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • complication of:
    • artificial heart device (T82.5-)
    • heart-lung transplant (T86.3-)
    T86.2-
    )
  • complications of liver transplant (
    ICD-10-CM Diagnosis Code T86.4

    Complications of liver transplant

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    T86.4-
    )
Code Also
Code Also Help
A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.
  • , if applicable, any associated condition, such as:
  • hypertensive emergency (
    ICD-10-CM Diagnosis Code I16.1

    Hypertensive emergency

      2017 - New Code 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    I16.1
    )
  • malignant neoplasm (
    ICD-10-CM Diagnosis Code C00

    Malignant neoplasm of lip

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • malignant melanoma of lip (C43.0)
    • Merkel cell carcinoma of lip (C4A.0)
    • other and unspecified malignant neoplasm of skin of lip (C44.0-)
    Use Additional
    • code to identify:
    • alcohol abuse and dependence (F10.-)
    • history of tobacco dependence (Z87.891)
    • tobacco dependence (F17.-)
    • tobacco use (Z72.0)
    C00
    -
    ICD-10-CM Diagnosis Code C96

    Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79)
    C96
    )
  • systemic lupus erythematosus (
    ICD-10-CM Diagnosis Code M32
    • M32 Systemic lupus erythematosus (SLE)
      • M32.0 Drug-induced systemic lupus erythematosus
      • M32.1 Systemic lupus erythematosus with organ or sy...
        • M32.10 Systemic lupus erythematosus, organ or system...
        • M32.11 Endocarditis in systemic lupus erythematosus
        • M32.12 Pericarditis in systemic lupus erythematosus
        • M32.13 Lung involvement in systemic lupus erythemato...
        • M32.14 Glomerular disease in systemic lupus erythema...
        • M32.15 Tubulo-interstitial nephropathy in systemic l...
        • M32.19 Other organ or system involvement in systemic...
      • M32.8 Other forms of systemic lupus erythematosus
      • M32.9 Systemic lupus erythematosus, unspecified
    M32.-
    )
The following code(s) above D59.39 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D59.39:
  • D50-D89
    2023 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D59.3
    ICD-10-CM Diagnosis Code D59.3

    Hemolytic-uremic syndrome

      2016 2017 2018 2019 2020 2021 2022 2023 - Converted to Parent Code Non-Billable/Non-Specific Code
    Code Also
    • , if applicable, any associated:
    • acute kidney failure (N17.-)
    • chronic kidney disease (N18.-)
    Hemolytic-uremic syndrome
ICD-10-CM D59.39 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 811 Red blood cell disorders with mcc
  • 812 Red blood cell disorders without mcc
Code History
  • 2023 (effective 10/1/2022): New code

Diagnosis Index entries containing back-references to D59.39:
  • Syndrome - see also Disease
    • hemolytic-uremic D59.30
      ICD-10-CM Diagnosis Code D59.30

      Hemolytic-uremic syndrome, unspecified

        2023 - New Code Billable/Specific Code
      Applicable To
      • Hemolytic-uremic syndrome NOS
      • atypical D59.39
        • secondary D59.39
        • specified NEC D59.39
      • secondary D59.39
      • specified NEC D59.39

ICD-10-CM Codes Adjacent To D59.39
D59.10 Autoimmune hemolytic anemia, unspecified
D59.11 Warm autoimmune hemolytic anemia
D59.12 Cold autoimmune hemolytic anemia
D59.13 Mixed type autoimmune hemolytic anemia
D59.19 Other autoimmune hemolytic anemia
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.30 …… unspecified
D59.31 Infection-associated hemolytic-uremic syndrome
D59.32 Hereditary hemolytic-uremic syndrome
D59.39 Other hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes
D59.8 Other acquired hemolytic anemias
D59.9 Acquired hemolytic anemia, unspecified
D60 Acquired pure red cell aplasia [erythroblastopenia]
D60.0 Chronic acquired pure red cell aplasia
D60.1 Transient acquired pure red cell aplasia
D60.8 Other acquired pure red cell aplasias
D60.9 Acquired pure red cell aplasia, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.