2020 ICD-10-CM Diagnosis Code D59.4

Other nonautoimmune hemolytic anemias

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D59.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D59.4 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D59.4 - other international versions of ICD-10 D59.4 may differ.
Applicable To
  • Mechanical hemolytic anemia
  • Microangiopathic hemolytic anemia
  • Toxic hemolytic anemia
The following code(s) above D59.4 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D59.4:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Approximate Synonyms
  • Hemolytic anemia due to babesiosis
  • Hemolytic anemia due to infection
  • Hemolytic anemia due to plasmodium falciparum
  • Hemolytic anemia with infection
  • Hemolytic anemia, babesiosis
  • Hemolytic anemia, microangiopathic
  • Hemolytic anemia, nonautoimmune
  • Hemolytic anemia, p falciparum
  • Hemolytic anemia, traumatic cardiac
  • Microangiopathic hemolytic anemia
  • Non-autoimmune hemolytic anemia
  • Polyagglutinable erythrocyte syndrome
  • Traumatic cardiac hemolytic anemia
Clinical Information
  • Acquired anemia due to destruction of red blood cells by physical trauma such as fibrin strands in the blood vessels, artificial heart valve, aortic coarctation. I can also be associated with hematologic diseases such as disseminated intravascular coagulation; hemolytic-uremic syndrome; and thrombotic thrombocytopenic purpura.
ICD-10-CM D59.4 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
  • 809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
  • 810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc

Convert D59.4 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to D59.4:
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
    ICD-10-CM Diagnosis Code D64.9

    Anemia, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • hemolytic D58.9
      ICD-10-CM Diagnosis Code D58.9

      Hereditary hemolytic anemia, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • acquired D59.9
        ICD-10-CM Diagnosis Code D59.9

        Acquired hemolytic anemia, unspecified

          2016 2017 2018 2019 2020 Billable/Specific Code
        Applicable To
        • Idiopathic hemolytic anemia, chronic
        • infectious D59.4
        • toxic D59.4
      • due to
        • cardiac conditions D59.4
        • presence of shunt or other internal prosthetic device D59.4
      • nonautoimmune D59.4
      • secondary D59.4
      • symptomatic D59.4
      • mechanical D59.4
      • microangiopathic D59.4
      • toxic D59.4
  • Disease, diseased - see also Syndrome
  • Nonautoimmune hemolytic anemia D59.4
  • Syndrome - see also Disease
    • erythrocyte fragmentation D59.4

ICD-10-CM Codes Adjacent To D59.4
D58.0 Hereditary spherocytosis
D58.1 Hereditary elliptocytosis
D58.2 Other hemoglobinopathies
D58.8 Other specified hereditary hemolytic anemias
D58.9 Hereditary hemolytic anemia, unspecified
D59 Acquired hemolytic anemia
D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes
D59.8 Other acquired hemolytic anemias
D59.9 Acquired hemolytic anemia, unspecified
D60 Acquired pure red cell aplasia [erythroblastopenia]
D60.0 Chronic acquired pure red cell aplasia
D60.1 Transient acquired pure red cell aplasia
D60.8 Other acquired pure red cell aplasias
D60.9 Acquired pure red cell aplasia, unspecified
D61 Other aplastic anemias and other bone marrow failure syndromes

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.